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How prostate cancer transforms into aggressive NEPC following treatment with anti-androgen therapy.
Because
serine
is a non-essential amino acid, treatments aimed at blocking
serine
production may be devised that could impact the tumor with minimal or no effect on the normal cells, thereby reducing potential toxicities.
Because
serine
is a non-essential amino acid, treatments aimed at blocking
serine
production may be devised that could impact the tumor with minimal or no effect on the normal cells, thereby reducing potential toxicities.
Scout4answers
in
Advanced Prostate Cancer
9 months ago
Selective amino acid restriction therapy (SAART)
For example,
serine
is required for the synthesis of cysteine, and
serine
and glycine are interconvertible through the enzymes
serine
hydroxymethyltransferases SHMT1 and SHMT2 (Figure (Figure1).1).
For example,
serine
is required for the synthesis of cysteine, and
serine
and glycine are interconvertible through the enzymes
serine
hydroxymethyltransferases SHMT1 and SHMT2 (Figure (Figure1).1).
pca2004
in
Fight Prostate Cancer
1 year ago
I very had Takasubo for two years hasnt changed it gets bad when I drink protein shakes. Some flavorings spark it off. Also Overheating
I've had Takasubo for two years, was under huge stress. Drank a protein shake and my body went into complete disfunction. Found I had Takasubo, with extreme low blood pressure. Taking blood thinners is the only help I've gotten. It has now happened many times. Every time I drink protein shakes. The
I've had Takasubo for two years, was under huge stress. Drank a protein shake and my body went into complete disfunction. Found I had Takasubo, with extreme low blood pressure. Taking blood thinners is the only help I've gotten. It has now happened many times. Every time I drink protein shakes. The
Lowbloodpressure
in
British Heart Foundation
6 days ago
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small bowel operation
Hello, my consultant has suggested doing a re-section of my small bowel to help my IBS C. Has anyone had this operation and if so, did it make a difference? When I have a really bad flare up, after about ten bowel movements, bile in my stomach goes up my oesophagus and I can’t stop vomiting bile until
Hello, my consultant has suggested doing a re-section of my small bowel to help my IBS C. Has anyone had this operation and if so, did it make a difference? When I have a really bad flare up, after about ten bowel movements, bile in my stomach goes up my oesophagus and I can’t stop vomiting bile until
Harley1020
in
IBS Network
11 days ago
Saline Solution IV
When in Scotland the winter before last I inquired in a post here about a Saline Solution IV. The how not to heal and why crowd went berserk. In the USA we have drip bars where one can purchase a Saline Solution IV. The cost is around $100.00 USD. When I travel, go through the stress of improved
When in Scotland the winter before last I inquired in a post here about a Saline Solution IV. The how not to heal and why crowd went berserk. In the USA we have drip bars where one can purchase a Saline Solution IV. The cost is around $100.00 USD. When I travel, go through the stress of improved
WIZARD6787
in
Pernicious Anaemia Society
21 days ago
Tips on how to recover from an ablation
Just had a RF ablation for PAF yesterday at the Harefield Heart Hospital. I'm glad to say the procedure went well. I have two tips to help. 1) ask for your canula to be inserted in the back of your hand rather than just under the elbow.It'smuch more comfortable and easier to find a vein and to extract
Just had a RF ablation for PAF yesterday at the Harefield Heart Hospital. I'm glad to say the procedure went well. I have two tips to help. 1) ask for your canula to be inserted in the back of your hand rather than just under the elbow.It'smuch more comfortable and easier to find a vein and to extract
manabouttown
in
Atrial Fibrillation Support
22 days ago
Back Again
Hello everyone, sorry in advance for the mammoth post. I was last on this forum about 7-8 years ago in 2015/2016 after my previous symptom free asthma flared up badly and left me very sick (back on inhalers, steroids, and multiple hospital admissions). We managed to get my asthma back under control
Hello everyone, sorry in advance for the mammoth post. I was last on this forum about 7-8 years ago in 2015/2016 after my previous symptom free asthma flared up badly and left me very sick (back on inhalers, steroids, and multiple hospital admissions). We managed to get my asthma back under control
Beth_19
in
Asthma Community Forum
22 days ago
Does anyone take this supplement?
I have been doing a lot of research on how to fix cramping. Let me first say, no pickle juice does not work. I also do not have fluid taken off during dialysis. I add 400ml of saline each treatment. I also have no fluid restrictions and so I do drink a lot of water. And none of my mineral labs indicate
I have been doing a lot of research on how to fix cramping. Let me first say, no pickle juice does not work. I also do not have fluid taken off during dialysis. I add 400ml of saline each treatment. I also have no fluid restrictions and so I do drink a lot of water. And none of my mineral labs indicate
Bassetmommer
in
Kidney Dialysis
1 month ago
Could MCAS a possibility?
Hello everyone, I have been wondering for a while if I could have MACS. Last year I was diagnosed with a Raw Pecan allergy, borderline brazil and salami allergy through raw food skin to skin prick testing and given epi pens. My immunologist at the time did not want to risk it as I have asthma and
Hello everyone, I have been wondering for a while if I could have MACS. Last year I was diagnosed with a Raw Pecan allergy, borderline brazil and salami allergy through raw food skin to skin prick testing and given epi pens. My immunologist at the time did not want to risk it as I have asthma and
Owl84
in
The UK Mastocytosis Support Group
1 month ago
Peritoneal dialysis catheter block
Hi everyone, for those on PD, have you had any catheter complications or blockages and how were they resolved? My father suddenly started to have his PD fluid drain bloody two weeks ago. We notified the nurse/dr who are both unresponsive and just assumed it’s a burst blood vessel. We requested a sample
Hi everyone, for those on PD, have you had any catheter complications or blockages and how were they resolved? My father suddenly started to have his PD fluid drain bloody two weeks ago. We notified the nurse/dr who are both unresponsive and just assumed it’s a burst blood vessel. We requested a sample
Marbella17
in
Kidney Disease
1 month ago
do I go ahead with a laparoscopy?
please help me - you’re the only community that who actually helps and understands! I have had 3 miscarriages(natural) - all early. Since my first miscarriage 14 months ago I have been in constant pain. 2/10 half the month and maybe 6-7 for maybe 1 week. I have heavy periods and recently clotting, especially
please help me - you’re the only community that who actually helps and understands! I have had 3 miscarriages(natural) - all early. Since my first miscarriage 14 months ago I have been in constant pain. 2/10 half the month and maybe 6-7 for maybe 1 week. I have heavy periods and recently clotting, especially
Maybeendo
in
Endometriosis UK
1 month ago
WHAT IS THE BEST DIET FOR BRONCHIECTASIS
I HAVE TONS of mucas all the time tho use saline neb and oscillating vest twice a day. adjustable bed but mucas still drains what is the best diet for this illness\?
I HAVE TONS of mucas all the time tho use saline neb and oscillating vest twice a day. adjustable bed but mucas still drains what is the best diet for this illness\?
Lapis5
in
Lung Conditions Community Forum
2 months ago
First Time Nebuliser Use
Hi everyone, my Respiratory Consultant has suggested I try nebulising with saline to help clear my chest and hopefully reduce the problem of mucus plugging which then impacts my breathing obviously. I’ve bought the nebuliser and have the saline on prescription. My query is I’ve read when using for the
Hi everyone, my Respiratory Consultant has suggested I try nebulising with saline to help clear my chest and hopefully reduce the problem of mucus plugging which then impacts my breathing obviously. I’ve bought the nebuliser and have the saline on prescription. My query is I’ve read when using for the
LizPat30
in
Lung Conditions Community Forum
2 months ago
Update on tests etc
hi all. Just an update after my recent CT scan, and the dreaded bronchoscopy on Tuesday this week. Obviously haven't had full results of latest CT scan, apart from a short note from my consultant to say there was a 6.5 millimetre nodule in ththe Apex of my right lung. They will monitor it, if it stays
hi all. Just an update after my recent CT scan, and the dreaded bronchoscopy on Tuesday this week. Obviously haven't had full results of latest CT scan, apart from a short note from my consultant to say there was a 6.5 millimetre nodule in ththe Apex of my right lung. They will monitor it, if it stays
Tiggertheterrier
in
Lung Conditions Community Forum
2 months ago
Salt water washing post adult Circumcision week 6
It has now almost been 6 weeks post my circumcision surgery and the dry patches of skin still linger on my glans and frenulum. I have read on this forum elsewhere that salt water washes help in clearing these dry patches. I was wondering if 1) I should dip it in saline solution before or after taking
It has now almost been 6 weeks post my circumcision surgery and the dry patches of skin still linger on my glans and frenulum. I have read on this forum elsewhere that salt water washes help in clearing these dry patches. I was wondering if 1) I should dip it in saline solution before or after taking
Bisyar
in
Men's Health Forum (Penis Health)
2 months ago
can't get a mucas culture from lungs.
I have had Bronchiectasis for five years and many lung infections.. Pseudomonas etc.and mos of Iv antibiotics. Have never had a problem getting a culure till now.. four times the lab said it was contaminated by oral something or other. So did not run it for respiratory disease. I even went to
I have had Bronchiectasis for five years and many lung infections.. Pseudomonas etc.and mos of Iv antibiotics. Have never had a problem getting a culure till now.. four times the lab said it was contaminated by oral something or other. So did not run it for respiratory disease. I even went to
Lapis5
in
Lung Conditions Community Forum
2 months ago
is my pain Endo + did it cause my miscarriages?
finally a community that I can ask! Please help as I’ve seen so many docs and none can give me an answer. I’ve had 3 miscarriages in 12 months. From ovulation from the 1st pregnancy and ever since I now have lower abdominal pain - maybe 3 out of 4 weeks of the month. I never had this pain before
finally a community that I can ask! Please help as I’ve seen so many docs and none can give me an answer. I’ve had 3 miscarriages in 12 months. From ovulation from the 1st pregnancy and ever since I now have lower abdominal pain - maybe 3 out of 4 weeks of the month. I never had this pain before
Maybeendo
in
Endometriosis UK
2 months ago
Question on steam/vapour breathing
I have a question for those who use steam/vapour breathing to ease off their symptoms. Do you use distilled water, reagular tap water, or a saline solution? My specialist seemed puzzled when I asked her this, and said that, in principle, a saline solution is optimal. I currently use distilled water.
I have a question for those who use steam/vapour breathing to ease off their symptoms. Do you use distilled water, reagular tap water, or a saline solution? My specialist seemed puzzled when I asked her this, and said that, in principle, a saline solution is optimal. I currently use distilled water.
runcyclexcski
in
Asthma Community Forum
3 months ago
Asthma
I'm on a high level of medication for my asthma I've been with lung specialist for 5 years, I was diagnosed with asthma in the 90s but it was mild enough for me to continue work, however as the years increased my asthma was starting to become a problem, well anyway now my asthma has become a real problem
I'm on a high level of medication for my asthma I've been with lung specialist for 5 years, I was diagnosed with asthma in the 90s but it was mild enough for me to continue work, however as the years increased my asthma was starting to become a problem, well anyway now my asthma has become a real problem
Happy103
in
Lung Conditions Community Forum
3 months ago
Rheumatologist advices no reduction of prednisolone while adrenal glands not working and has issued emergency hydrocortisone kit
I've had PMR since October 2020 and managed to get down to 2.5mg of prednisolone in February 2023. But after a flare, I had to raise it to 5mg and have been pain-free since then. I started on methotrexate weekly injections (15mg) in December 2023, with the hope of being able to reduce the prednisolone
I've had PMR since October 2020 and managed to get down to 2.5mg of prednisolone in February 2023. But after a flare, I had to raise it to 5mg and have been pain-free since then. I started on methotrexate weekly injections (15mg) in December 2023, with the hope of being able to reduce the prednisolone
harpsichor
in
PMRGCAuk
3 months ago
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