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FDA approves niraparib and abiraterone acetate plus prednisone for BRCA-mutated metastatic castration-resistant prostate cancer - 08/11/2023
On August 11, 2023, the Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined
On August 11, 2023, the Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined
cujoe
in
Fight Prostate Cancer
11 months ago
HT weight gain
My husband will be starting hormone therapy <HT> prior to radiation treatment <RT>.The weight gain associated with HT is a concern. Any suggestions? Any medication available to assist with weight loss during HT? Inquisitive One
My husband will be starting hormone therapy <HT> prior to radiation treatment <RT>.The weight gain associated with HT is a concern. Any suggestions? Any medication available to assist with weight loss during HT? Inquisitive One
Inquisitive_one
in
Advanced Prostate Cancer
7 months ago
newbie - help please
Hi I hope you can give me some pointers /help as I’m trying to work out what I need to treat first and my GP is not very helpful. I am 49 and on HRT (evorel 50 & utrogestan ). I have known for a while that I have subclinical hypothyroid as I have had regular blood tests over the years and at times
Hi I hope you can give me some pointers /help as I’m trying to work out what I need to treat first and my GP is not very helpful. I am 49 and on HRT (evorel 50 & utrogestan ). I have known for a while that I have subclinical hypothyroid as I have had regular blood tests over the years and at times
Arewethereyet96
in
Thyroid UK
7 months ago
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TSH & T4 levels
Hi everyone I’m new here. Can someone help me settle a bit of an argument around TSH & T4 levels please? I have recently had a consultation with Newson health who tell me on 100mcg thyroxine my TSH should be <1. My GP is denying that stating my TSH is normal at 2.5. My T4 is 18.0. I have felt like
Hi everyone I’m new here. Can someone help me settle a bit of an argument around TSH & T4 levels please? I have recently had a consultation with Newson health who tell me on 100mcg thyroxine my TSH should be <1. My GP is denying that stating my TSH is normal at 2.5. My T4 is 18.0. I have felt like
Gillne
in
Thyroid UK
7 months ago
HRT question: how long did it take to feel the effects?
I have been struggling with crushing anxiety, insomnia, depression for a few months. It's unlike anything I have ever experienced. I started HRT last week, and am hoping for a little easing of symptoms soon! Just curious about other women's experiences. Please share!
I have been struggling with crushing anxiety, insomnia, depression for a few months. It's unlike anything I have ever experienced. I started HRT last week, and am hoping for a little easing of symptoms soon! Just curious about other women's experiences. Please share!
Margaret_712
in
Women's Health
7 months ago
severe neck pain
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
Tommyj2
in
Advanced Prostate Cancer
7 months ago
Latest Private Blood Test Results.
Hi, I’m just looking for thoughts on my latest blood test results. I’m feeling ok, but still get tired. currently on (Levothyroxine 75mgs and T3 10mgs ). Daily. I also take vitamins c, magnesium, folate, omega 3,6,7&9. I also take HRT progesterone & Estrogel
Hi, I’m just looking for thoughts on my latest blood test results. I’m feeling ok, but still get tired. currently on (Levothyroxine 75mgs and T3 10mgs ). Daily. I also take vitamins c, magnesium, folate, omega 3,6,7&9. I also take HRT progesterone & Estrogel
Bright-eyes
in
Thyroid UK
7 months ago
PROTACs: another technique to help with mCRPC
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both castration resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both castration resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
Maxone73
in
Advanced Prostate Cancer
7 months ago
PSA rise soon after surgery!
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 50%) Ralp surgery robotic
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 50%) Ralp surgery robotic
Daddysgirl83
in
Advanced Prostate Cancer
11 months ago
Psa rise soon after surgery, help!
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 40%). Ralp surgery robotic
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 40%). Ralp surgery robotic
Daddysgirl83
in
Fight Prostate Cancer
11 months ago
Results of MRI
So saw the endometriosis consultant today and he was very good. My MRI scan came back and showed extensive endometriosis that has obliterated my Pouch of Douglas and fully attached my rectum and bowel to my cervix. I've got an endo cyst on my left ovary and blood in left fallopian tube. Cervix is swollen
So saw the endometriosis consultant today and he was very good. My MRI scan came back and showed extensive endometriosis that has obliterated my Pouch of Douglas and fully attached my rectum and bowel to my cervix. I've got an endo cyst on my left ovary and blood in left fallopian tube. Cervix is swollen
Sunset-lady
in
Endometriosis UK
7 months ago
Hrt terrible sweats
I am sweating really bad being on zumenon for 4 months and nothing stopping it would like some advice plz
I am sweating really bad being on zumenon for 4 months and nothing stopping it would like some advice plz
Lauramcknight
in
PMRGCAuk
7 months ago
Help with blood results
I recently posted here for advice on whether I need levothyroxine as I have been subclinical for 10 years and now my tsh seems to be creeping up the last few weeks from 4.88 to 5.59 and now 6.15 all in the space of 3/4 weeks. I wonder if it is linked to the introduction of testosterone, I started hrt
I recently posted here for advice on whether I need levothyroxine as I have been subclinical for 10 years and now my tsh seems to be creeping up the last few weeks from 4.88 to 5.59 and now 6.15 all in the space of 3/4 weeks. I wonder if it is linked to the introduction of testosterone, I started hrt
Rambler16
in
Thyroid UK
7 months ago
3,100 PSA!
After two (2) Pluvicto infusions, my PSA went from 2,000. to 3,000. I haven't had any hormone treatments for approximately six months, and was subsequently told my Dr. should have kept me on Standard of Care (SoC) right through Pluvicto. Q1: Anyone out there know of any options open to me in this
After two (2) Pluvicto infusions, my PSA went from 2,000. to 3,000. I haven't had any hormone treatments for approximately six months, and was subsequently told my Dr. should have kept me on Standard of Care (SoC) right through Pluvicto. Q1: Anyone out there know of any options open to me in this
fsiefert
in
Advanced Prostate Cancer
7 months ago
help please - severe osteoporosis-3.5 on DEXA scan I’m just 48
hi hi Results DEXA Basically osteoporosis with ranges between -2.5 and -3.5 t score last thyroid T4 - 19 (12 to 22) Tsh - less than 0.01 T3 5.8 (4.1 to 6.8) my range at hospital is 4.1 to 6.8 previous to starting t3 med my t3 was 2.1 - probsbly for years! I haven’t started hrt so no wonder
hi hi Results DEXA Basically osteoporosis with ranges between -2.5 and -3.5 t score last thyroid T4 - 19 (12 to 22) Tsh - less than 0.01 T3 5.8 (4.1 to 6.8) my range at hospital is 4.1 to 6.8 previous to starting t3 med my t3 was 2.1 - probsbly for years! I haven’t started hrt so no wonder
Chouchou1234
in
Thyroid UK
7 months ago
Lump on buttocks due to FULVESTRANT injection
My mom is diagnosed with stage 4 breast cancer .. currently she is on her hormonal therapy ..FULVESTRANT injection are injected ....the injections are injected on buttocks ..due to this there is lump on her buttocks, but its not going away , even after all the cold , hot compress..so what should i do
My mom is diagnosed with stage 4 breast cancer .. currently she is on her hormonal therapy ..FULVESTRANT injection are injected ....the injections are injected on buttocks ..due to this there is lump on her buttocks, but its not going away , even after all the cold , hot compress..so what should i do
Hidden
in
Breast Cancer India
7 months ago
Is it safe to use red light / near infrared therapy if you have Graves' disease?
Hi all, First a little bit of background about me. I am 49, living in Ireland. I have Graves's disease diagnosed by an endocrinologist who did antibody test etc.. After diagnosis I underwent 18 months on Carbimazole and then came off for a couple of months but my T3 and T4 shot back up again (and TSH
Hi all, First a little bit of background about me. I am 49, living in Ireland. I have Graves's disease diagnosed by an endocrinologist who did antibody test etc.. After diagnosis I underwent 18 months on Carbimazole and then came off for a couple of months but my T3 and T4 shot back up again (and TSH
MyNameIsAugust
in
Thyroid UK
11 months ago
Working with Stage IV
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
BigJ32
in
Advanced Prostate Cancer
6 months ago
PSA of <0.1 undetectable?
I am on ADT, lupron and Zytiga, at Kaiser Oakland. My latest PSA came back as <0.1. My MO sent me a message with the results: "congratulations, great news, your PSA is undetectable!" I thought undetectable was 0.01, is it more likely she misread the number or that the lab used by Kaiser only reports
I am on ADT, lupron and Zytiga, at Kaiser Oakland. My latest PSA came back as <0.1. My MO sent me a message with the results: "congratulations, great news, your PSA is undetectable!" I thought undetectable was 0.01, is it more likely she misread the number or that the lab used by Kaiser only reports
pj1121
in
Advanced Prostate Cancer
7 months ago
PSA results After 5Cycles of pBAT
Everything looking good after 5 cycles of propionate BAT. Refresher: HSPC, did1 year ADT Lupron-->Orgovyx + Darolutamide before embarking on pBAT. Is this chart readable
Everything looking good after 5 cycles of propionate BAT. Refresher: HSPC, did1 year ADT Lupron-->Orgovyx + Darolutamide before embarking on pBAT. Is this chart readable
KocoPr
in
Fight Prostate Cancer
7 months ago
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