Experiences with

Peroxisome biogenesis disorders

Just want to update everyone who follows my case. Now, 6 weeks after stopping my 12-week Tanganil cure , I still haven’t had one single event with RBD; no nightmares, kicking or screaming or talking while sleeping. Possibly one or two very mild twitches from my feet in all 6 weeks but I never woke

I was wondering if anyone had developed sleep apnea and could link it to anything to do with their thyroid condition? I had my thyroid removed 7 years ago. In the last few months I’ve been waking myself up multiple times during the night with ‘snorts and gasps’ like snoring but literally just one time

As a follow on from: https://healthunlocked.com/thyroiduk/posts/151523579/timing-of-dosage?responses=151536677 I decided to start taking my levo at night. Everything seems fine with it, and I feel like I fall asleep quicker, and the sleep I'm getting is of better quality - [i]when [/i]I'm asleep. See

Hello everybody, I am new to the community. I have been following your forum because of my mother. She is 89 years old. For the last 5 years her RLS has aggravated dramatically. It became even worse after she was put on mirapex plus gabapentine about a year ago. Gabapentin has a very negative effect

I am delighted to announce that our next NoSilverBullet Zoom webinar will take place at 7:30 pm London time on Thursday, the 13th of March. Join us for a deep dive into the sleep challenges faced by Parkinson's patients and the potential solutions with Prof S Overeem! Please use the Eventbrite link

Has anyone else been told there is a national shortage of this yet the GP dispensing practice is telling me that I will have to wait for a new inhaler until the beginning of March when they might have sorted something out I know there is very little left in my current inhaler so naturally am worried

Hi, I am so wondering if someone received Topotecan as a treatment 3x 21 days.I have ovarian cancer plus pleural effusion and lymph nodes metastasis .

Has anyone successfully treated persistant chronic endometritis? I have had three rounds of antibiotics followed by vaginal and oral probiotics. Just had a third biopsy yesterday and wondering what on earth to do if it's positive again. Thanks xx

hi ladies, I am in a very fortunate position to be 11 weeks pregnant. However, I have been injecting prontogest, into my bum cheeks (alternating daily) since 11th December. I am really struggling now with the solid, extremely sore lumps in the muscle. I think I’ll only be doing these for another week

I'm in the UK and recently there have been several articles in the press about the side effects of dopamine agonist, particularly compulsive behaviour. The BBC are planning to highlight people's experiences in a programme. I have been approached and I am under discussion with a journalist. I have to

hi everyone, woykd you please be able to share your betahcg levels on your blood test day and share whether you transferred 1 or 2 embryos and whether the pregnancy was successful / viable ? Ths question comes often so I thought it would be nice to gather all the data in one place. :-) thanks everyone

my LDH has been consistently rising since my CLL diagnosis in 2020. Past two blood draws (six months apart) it has been outside of (above) normal. But all my other numbers are steady. Been on watch and wait. But getting nervous. The doctors say they aren’t worried. My total lymphs are 8.4. LDH is 289

We've just got comfortable with thyroid hormones, and TSH, and deiodinases, and conversions, We know of the hypothalamus, TRH, multiple forms of TSH, glycosylation, etc. And then along comes a complete outsider threatening to become super-important! Please understand, I post these things out of interest

The study compared the efficacy of different non-pharmacological interventions for sleep disorders in patients with PD, and results suggest that massage therapy may be the preferred non-pharmacological intervention for improving sleep disorders in PD, followed by music therapy and treadmill training

Interesting topic: https://pubmed.ncbi.nlm.nih.gov/17702867/ Results of this experiment suggest that loss of locus coeruleus neurons contributes to motor dysfunction in PD. Norepinephrine Deficiency in Parkinson's Disease: The Case for Noradrenergic Enhancement https://www.researchgate.net/publication

HELP!! Just changed GP practices and went for a new patient appointment this afternoon. Explained I had RLS, was originally on Ropinirole, but discontinued in 2017 due to augmentation. At the time I had a very receptive and understanding GP who agreed to prescribe Targinact 15mg. Been on it ever since

My mother, 75 years old, was sent for a beta 2-microglobulin test due to anxiety and palpitations.All her blood work results are excellent, except for the b2mg, which is 3. Should I be worried?

So I am 41 years old and I've been overweight most of my adult life. I suffer with binge eating and have done for as long as I can remember. I chose to eat for any occasion - happy or sad and life seems to revolve around meals, snacks and generally being unhealthy so it's time to make some changes

I have stopped using Neupro patches, but still have to take 3 x 100 mg Levodopa/Carbidopa because I also have Parkinson. For the first time I took 100 mg Gabapentin at 8 pm. It made me feel dazed. I went to bed at 11 pm. My legs didn't realy feel calm. At about 1 am RLS started to kick in and it

EP is switching me from Verapamil to Acebutolol for PVCs and high resting/low activity heart rate. Has anyone been on Acebutolol, if so how did it go? I am 3.5 months post ablation (still in blanking period), and have been cycled through sotolol, metoprolol, mexiletine, diltiazem, propafenone, and verapamil