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Palbociclib
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IBrance alternative dosing schedule : (5 on 2 off) another trial in the works
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
Dragonfly2
in
SHARE Metastatic Breast Cancer
2 years ago
Rising ESR1 Mutations During Aromatase Inhibitor and Palbociclib Therapy
[i]
Patients in whom an increase in blood ESR1 mutation levels was detected with no synchronous disease progression were randomised to either continue treatment with first-line aromatase inhibitors and
or switch to fulvestrant and
palbociclib
.
[i]
Patients in whom an increase in blood ESR1 mutation levels was detected with no synchronous disease progression were randomised to either continue treatment with first-line aromatase inhibitors and
or switch to fulvestrant and
palbociclib
.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
New Study released Re: five on/two off Ibrance dosing
term=
palbociclib
+alternative+dosing&draw=2&rank=1
term=
palbociclib
+alternative+dosing&draw=2&rank=1
Godbeforme
in
SHARE Metastatic Breast Cancer
2 years ago
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timing of medications
These are the full list: Levothyroxine Symbicort puffer
Palbociclib
Letrozole Calcium tabs Vit d3 Vit k Thorne b complex Glucosamine / chondroitin Many thanks (in hopeful anticipation)
These are the full list: Levothyroxine Symbicort puffer
Palbociclib
Letrozole Calcium tabs Vit d3 Vit k Thorne b complex Glucosamine / chondroitin Many thanks (in hopeful anticipation)
bikebabe
in
Thyroid UK
2 years ago
Overall Survival With Palbociclib and Fulvestrant in Women With HR+/HER2− Advanced Breast Cancer
This "updated exploratory analysis" (https://aacrjournals.org/clincancerres/article/28/16/3433/707399/Overall-Survival-with-
Palbociclib
-and-Fulvestrant) indicates: "superior overall survival (OS) outcomes with
palbociclib
plus fulvestrant compared with fulvestrant alone in patients with HR+/HER2− advanced
This "updated exploratory analysis" (https://aacrjournals.org/clincancerres/article/28/16/3433/707399/Overall-Survival-with-
Palbociclib
-and-Fulvestrant) indicates: "superior overall survival (OS) outcomes with
palbociclib
plus fulvestrant compared with fulvestrant alone in patients with HR+/HER2− advanced
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Weekly schedule of 5 days on, and two days off CDK4/6 inhibitors
I am hoping to be able to tell him about the experiences of other breast cancer patients on this schedule with any one of
palbociclib
, abemaciclib or ribociclib. Thanks for any help you may give me.
I am hoping to be able to tell him about the experiences of other breast cancer patients on this schedule with any one of
palbociclib
, abemaciclib or ribociclib. Thanks for any help you may give me.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Palbociclib and Overall Survival
Palbociclib
is the only CDK4/6 inhibitor that did not demonstrate an OS benefit in the first-line setting in patients with ER+/HER2− ABC. – Jing Xi, MD, MPH
Palbociclib
is the only CDK4/6 inhibitor that did not demonstrate an OS benefit in the first-line setting in patients with ER+/HER2− ABC. – Jing Xi, MD, MPH
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Proton Pump Inhibitors / Ibrance interaction
So I was somewhat alarmed to read various reports which show that proton pump inhibitors such as omeprazole and lansoprazole can significantly affect the length of progression free survival of those on
Palbociclib
.
So I was somewhat alarmed to read various reports which show that proton pump inhibitors such as omeprazole and lansoprazole can significantly affect the length of progression free survival of those on
Palbociclib
.
Laskia
in
SHARE Metastatic Breast Cancer
2 years ago
For those of you with horrible side effects on Ibrance!
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
SunShineEveryDay
in
SHARE Metastatic Breast Cancer
2 years ago
Ibrance and hazy vision?
Dear all Several of you have reported watery eyes and tears caused by Ibrance/
Palbociclib
. I've had that in the past, then it stopped, but over the past weeks I have developed hazy vision, as though seeing everything in constant very light smog.
Dear all Several of you have reported watery eyes and tears caused by Ibrance/
Palbociclib
. I've had that in the past, then it stopped, but over the past weeks I have developed hazy vision, as though seeing everything in constant very light smog.
MadameKa
in
SHARE Metastatic Breast Cancer
2 years ago
Unsatisfactory appointment
He offered me two months
palbociclib
, so I said I'd been having three and had planned my life around it. He questioned my calcium levels and whether I could have my next zolondronic acid infusion. When I said I always have blood test beforehand he didn't seem to know.
He offered me two months
palbociclib
, so I said I'd been having three and had planned my life around it. He questioned my calcium levels and whether I could have my next zolondronic acid infusion. When I said I always have blood test beforehand he didn't seem to know.
Beryl71
in
SHARE Metastatic Breast Cancer
2 years ago
Interested in targeted drugs? Here's some basic information
Research is even being done to develop a form of
palbociclib
to use as adjuvant therapy in early BC. However, it seems there remains much to learn about when, and for whom, targeted drugs should be prescribed.
Research is even being done to develop a form of
palbociclib
to use as adjuvant therapy in early BC. However, it seems there remains much to learn about when, and for whom, targeted drugs should be prescribed.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
2nd opinion about treatment change?
Palbociclib
+ letrozole combo made everything go away, until it stopped working 9 months later and new mets started to appear on different various bones. So switched to Everolimus + Faslodex, which also gave a complete response for about 9 months.
Palbociclib
+ letrozole combo made everything go away, until it stopped working 9 months later and new mets started to appear on different various bones. So switched to Everolimus + Faslodex, which also gave a complete response for about 9 months.
Here_now
in
SHARE Metastatic Breast Cancer
2 years ago
Liver mets question 🙋♀️
Having been bone only since 2018, on leterzol and
palbociclib
, my last Ct came back with subtle changes to the texture of the liver. I’m now awaiting a MRI and in a panic. oncologist has said it isn’t certain it’s a spread yet, but as you can imagine I’m in a spin.
Having been bone only since 2018, on leterzol and
palbociclib
, my last Ct came back with subtle changes to the texture of the liver. I’m now awaiting a MRI and in a panic. oncologist has said it isn’t certain it’s a spread yet, but as you can imagine I’m in a spin.
Glas0824
in
SHARE Metastatic Breast Cancer
3 years ago
Erolimus and Exemestane Treatment after Palbociclib stops working.
I am reaching out reference feedback on the Exemestane and Everolimus ( EE) treatment for SBC . I have lesions in spine, pelvis, occipital and just recently an additional 2 small ones in my liver. My oncologist had taken me off Palbocyclib and Letrozole ( which had worked successfully for 2 years) and
I am reaching out reference feedback on the Exemestane and Everolimus ( EE) treatment for SBC . I have lesions in spine, pelvis, occipital and just recently an additional 2 small ones in my liver. My oncologist had taken me off Palbocyclib and Letrozole ( which had worked successfully for 2 years) and
POPS60
in
SHARE Metastatic Breast Cancer
3 years ago
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Furthermore, the combination of ARV-471 and CDK4/6 inhibitor
palbociclib
showed great superiority over the combination of fulvestrant with
palbociclib
in tumor regressions.
Furthermore, the combination of ARV-471 and CDK4/6 inhibitor
palbociclib
showed great superiority over the combination of fulvestrant with
palbociclib
in tumor regressions.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Alternative dosing for IBrance , 5 days on/ 2 days off
So here we are…https://www.practiceupdate.com/content/efficacy-of-an-alternative-schedule-of-
palbociclib
-in-reducing-the-incidence-of-grade-3-or-above-neutropenia/138078 Apparently the alternative dosing is safe and does alleviate the problems with neutropenia.
So here we are…https://www.practiceupdate.com/content/efficacy-of-an-alternative-schedule-of-
palbociclib
-in-reducing-the-incidence-of-grade-3-or-above-neutropenia/138078 Apparently the alternative dosing is safe and does alleviate the problems with neutropenia.
Dragonfly2
in
SHARE Metastatic Breast Cancer
2 years ago
Sore feet
I have been on
palbociclib
and letrozole for 3.5 years. For the last 6 weeks I have experienced very dry soles of my feet that are painful in places. Anyone experience this too? I didn't think this medication had these side effects. Fay
I have been on
palbociclib
and letrozole for 3.5 years. For the last 6 weeks I have experienced very dry soles of my feet that are painful in places. Anyone experience this too? I didn't think this medication had these side effects. Fay
Rotagirl
in
SHARE Metastatic Breast Cancer
3 years ago
Can you continue medication if you get covid
I’m on letrozole and
palbociclib
. With 12 weekly Xgeva. Have only been on it for 4 months.
I’m on letrozole and
palbociclib
. With 12 weekly Xgeva. Have only been on it for 4 months.
Rosiero
in
SHARE Metastatic Breast Cancer
3 years ago
Same as Carole, “new....well sort of ; )”
Since then, I have had eleven different treatments (Letrozole,
Palbociclib
, Fulvestrant, Capecitabine, Eribulin, Navelbine, etc.) and none of them worked more than a year. Two years after genetic testing, they suddenly informed me I am BRCA1 mutation.
Since then, I have had eleven different treatments (Letrozole,
Palbociclib
, Fulvestrant, Capecitabine, Eribulin, Navelbine, etc.) and none of them worked more than a year. Two years after genetic testing, they suddenly informed me I am BRCA1 mutation.
s_yenju
in
SHARE Metastatic Breast Cancer
3 years ago
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