New Study released Re: five on/two off Ibrance dosing

[Godbeforme]

I believe this is the completion of the 2nd trial for the alternative dosing (5 on/2 off) of ibrance, just released TODAY! Someone who knows how to read these things, please tell me what I did wrong that I couldn't find their "conclusion" or "recommendation" after completing the study. Thanks for any light you can shed on this! I have trouble understanding all the jargon but for what I did read, it sounded very promising! Clarify please! <3 God bless you and heal us all in Jesus name, amen!

clinicaltrials.gov/ct2/show...

[Nocillo]

I’m on a 3 week on and 2 weeks off which is working well for me. I agree with you that I don’t see a conclusion to the study other than the side effects chart. The one thing I would not want to deal with is the Goserelin shot once a month. I’m not sure what Goserelin is, but adding another shot or appointment does not appeal to me. Maybe someone else can tell us more about this.

[Godbeforme in reply to Nocillo]

thanks for the response! I'm just wondering if NOT having the 7 days off is an issue. I'm thinking of being my own study LOL 5/2, 5/2, 5/2, 5/7 . This malarky will make you crazy! <3 xo

[Nocillo in reply to Godbeforme]

Yes it can!

[Dragonfly2]

this is what I’m getting from previous evaluations : TAKE-HOME MESSAGEThis phase II trial investigating an alternative dosing schedule of palbociclib in patients with HR-positive/HER2-negative advanced/metastatic breast cancer showed that a 5-days-on/2-days-off weekly schedule reduced the incidence of grade 3 and above neutropenia and improved the tolerability of palbociclib compared with historical data of palbociclib trials. Serial monitoring of serum thymidine kinase 1 (sTK1) activity showed a significant reduction of sTK1 at cycle 1 day 15 and cycle 2 day 1, indicating that this alternative dosing schedule achieved effective target inhibition.The 5-days-on/2-days-off weekly dosing schedule of palbociclib reduced hematological toxicity without compromising efficacy in this patient population.

All I can say that this 5/2 schedule is working well for me. I’m not getting any other shots of fulvestrant or goserelin. I have my sanity, I’m comfortable, and moving forward. Recent scans were stable, and despite a variety of vaccines in the fall, my tumor markers are all within my best numbers.

I do not miss the neutropenia that was undermining my enjoyment of life. 🥰