Palbociclib and Overall Survival

[Hazelgreen]

Published in Metastatic Breast Cancer and

Journal Scan / Research · June 30, 2022

Overall Survival With First-Line Palbociclib Plus Letrozole vs Placebo Plus Letrozole in Women With ER+/HER2− Advanced Breast Cancer

Journal of Clinical Oncology

TAKE-HOME MESSAGE

This updated overall survival (OS) analysis of the PALOMA-2 trial showed that, after a median follow-up period of 90 months, palbociclib plus letrozole resulted in a numerically, but not statistically significant, longer OS compared with letrozole alone for the first-line treatment in postmenopausal women with ER+/HER2− advanced breast cancer (ABC).

Palbociclib is the only CDK4/6 inhibitor that did not demonstrate an OS benefit in the first-line setting in patients with ER+/HER2− ABC.

– Jing Xi, MD, MPH

[Susan1953]

Interesting information. I have been on the Ibrance and Letrozole combo over 5 years without progression.

[Hazelgreen in reply to Susan1953]

There is more information in the abstract: ascopubs.org/doi/abs/10.120...

"median OS (95% CI) was 53.9 months (49.8–60.8) in the PAL+LET arm and 51.2 months (43.7 –58.9) in the PBO+LET arm (hazard ratio, 0.956 [95% CI, 0.777–1.177]; stratified 1-sided P=0.3378)"

[Susan1953 in reply to Hazelgreen]

Thanks. I am 69 and hoping to live to see my grandchildren grow up. I go to MDA from Alabama for scans and Dr. visits. Living For The Cure

[Hazelgreen in reply to Susan1953]

Clearly, Susan, at 60 months, you are in the more successful 50% (top half of the median). I'm sure there are many women from the original study still going strong!

[lambee9 in reply to Hazelgreen]

In fact, with 60 months progression-free survival, Susan is way outperforming the median 24.8 month median PFS from their drug trial. Go Susan! SO INSPIRING to hear real world evidence of these drugs working so well. There aren't great statistics available of how long women are surviving with mbc.

[Tantalon7211 in reply to Susan1953]

That’s wonderful to hear- how many mg of Ibrance are you on? I am just starting on anastronole(letrozole) and having severe nausea and diareahh - supposed to start Ibrance/ I hope I can do it and have success like you - Side effects hopefully subside

[Susan1953 in reply to Tantalon7211]

I am on 125 mg Ibrance since April 2017. I have minimal side effects probably from the letrozole. My hands have joint pain and by bedtime I am exhausted but I go strong all day.

[TammyCross in reply to Tantalon7211]

Are you taking anastrazole or letrozole? I had an allergic reaction to letrozole, and other side effects, so onc switched me to anastrazole, which I tolerate much better.

[NPmary]

I beat another statistics- still here, 5 years on 7/13!

[Susan1953 in reply to NPmary]

it feels like passing that 5 years is a reason to celebrate. Congrats and lets live for the cure!

[NPmary in reply to Susan1953]

Thank uou. And 5 years for you too. Yeah.

[Suzianna10 in reply to NPmary]

That’s great, keep on going

[NPmary in reply to Suzianna10]

Thank you

[NPmary in reply to Suzianna10]

Thank yo.

[kokopelli2017 in reply to NPmary]

congrats Mary!

almost there. 4 yrs and 8 months. letrozole only! bone mets and several lymph nodes in L side of neck. 'knock on wood'😉.

carole XO

[Tolife_18]

Thank you very much for sharing.

In addition to OS, PFS (progression free survival) is very important. It’s not always coincide with OS. PFS in PALOMA-2 was statistically significant leading to approval, but OS reported after 90-month follow-up is not. It’s also important to note that this is a data from the follow-up of the patients enrolled years ago in the original clinical study. It’d be interesting to know the results from the real world data. I’m sure Pfizer will provide that to support the approval.

[love2golfwell]

When I was first diagnosed with MBC my original oncologist wanted to put me on Verzenio as she said that there was no survivorship data about Ibrance. Since I was moving the following month to another state I did not start on anything. When I came to Florida, my oncologist here recommended Ibrance and said there was survivorship data. I am on 125mg Ibrance with letrozole since November of 2020. So far so good. The only side effect is hair thinning and some loss and loss of eyelashes and eyebrows. I feel great otherwise. I really did not want to have the diarrhea that Verzenio can cause as I dealt with issues like that for many, many years as a teenager and young adult due to stressed induced IBS and it was not fun! I am hoping to stay on this combo for a long time, so it is great to see that Susan1953 has been on this combo for over 5 years. I would be extremely happy to do that as well!