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Experiences with
Palbociclib
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Palbociclib for MF reducing fibrosis and more
"The drug,
palbociclib
, may be able to prevent the scarring of bone marrow that existing treatments (Rux etc) for myelofibrosis cannot."
"The drug,
palbociclib
, may be able to prevent the scarring of bone marrow that existing treatments (Rux etc) for myelofibrosis cannot."
EPguy
in
MPN Voice
1 month ago
On Palbociclib and Letrozole for 21 days, CA153 elevated. Er+Her2-
I've been on a regimen of
Palbociclib
and Letrozole for the past 19 days, and recently, I received my CA153 test results. Last month, before starting the
Palbociclib
and Letrozole treatment, my CA153 level was recorded at 137.
I've been on a regimen of
Palbociclib
and Letrozole for the past 19 days, and recently, I received my CA153 test results. Last month, before starting the
Palbociclib
and Letrozole treatment, my CA153 level was recorded at 137.
MuhammadZain
in
My Breast Cancer Community
5 months ago
travel insurance (again)
for those on
palbociclib
, when asked if you’re on chemotherapy and you can only give a yes /no answer do you say yes as palbo is a targeted chemo?
for those on
palbociclib
, when asked if you’re on chemotherapy and you can only give a yes /no answer do you say yes as palbo is a targeted chemo?
bikebabe
in
SHARE Metastatic Breast Cancer
4 months ago
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Cardiac open heart surgery
I've not had
palbociclib
for several weeks already because of a post-covid cold which the surgeons aren't too bothered about but it means I won't be having palbo for several more weeks until healed and I'm 2.3 yrs into palbo/letrozole treatment .
I've not had
palbociclib
for several weeks already because of a post-covid cold which the surgeons aren't too bothered about but it means I won't be having palbo for several more weeks until healed and I'm 2.3 yrs into palbo/letrozole treatment .
bikebabe
in
SHARE Metastatic Breast Cancer
4 months ago
5/2 alternative schedule for ibrance study
Copied from under "Abstract" paragraph:
Palbociclib
, 5-days-on/2-days-off weekly, met its primary endpoint with reduced G3 + ANC, without compromising efficacy. sTK1 is prognostic and shows promise in monitoring the
palbociclib
response. ClinicalTrials.gov#: NCT3007979. Here's the whole article.
Copied from under "Abstract" paragraph:
Palbociclib
, 5-days-on/2-days-off weekly, met its primary endpoint with reduced G3 + ANC, without compromising efficacy. sTK1 is prognostic and shows promise in monitoring the
palbociclib
response. ClinicalTrials.gov#: NCT3007979. Here's the whole article.
Godbeforme
in
SHARE Metastatic Breast Cancer
8 months ago
Silent urinary tract infection
Haven’t had any
palbociclib
since December due to covid reaction/ ops and it was originally grade 3 pleomorphic. I have no desire to repeat this traumatising experience despite excellent care - way too many needles and cannulas for one.
Haven’t had any
palbociclib
since December due to covid reaction/ ops and it was originally grade 3 pleomorphic. I have no desire to repeat this traumatising experience despite excellent care - way too many needles and cannulas for one.
bikebabe
in
SHARE Metastatic Breast Cancer
2 months ago
Spare/leftover/unopened drugs on offer for free
There’s one full pack of
Palbociclib
/Ibrance. 100mg. And there’s also a packet of anastrozole. Please refer to the photo I’ve put here. If anyone to use these I’m very happy to post them to you anywhere in the world.
There’s one full pack of
Palbociclib
/Ibrance. 100mg. And there’s also a packet of anastrozole. Please refer to the photo I’ve put here. If anyone to use these I’m very happy to post them to you anywhere in the world.
Timtam56
in
SHARE Metastatic Breast Cancer
6 months ago
New primary plus first progression
I had a mastectomy and axillary clearance left side and then
palbociclib
, letrezole, monthly goserelin and denusamab. I have just found out I have my first progression spine and possible lesion on my liver but more concerning a new primary lobular carcinoma in my right breast and armpit lymph.
I had a mastectomy and axillary clearance left side and then
palbociclib
, letrezole, monthly goserelin and denusamab. I have just found out I have my first progression spine and possible lesion on my liver but more concerning a new primary lobular carcinoma in my right breast and armpit lymph.
RachH20
in
SHARE Metastatic Breast Cancer
8 months ago
Timing of meds
Currently: 7am T4/T3 with oral asthma spray 9.30am Breakfast with
palbociclib
, letrozole and oral spray Vit D/K2 3pm T3 (5mcg)* 6pm Glucosamine/chondroitin 10pm Calcium *I struggle to remember the afternoon T3 dose as despite phone alerts,
Currently: 7am T4/T3 with oral asthma spray 9.30am Breakfast with
palbociclib
, letrozole and oral spray Vit D/K2 3pm T3 (5mcg)* 6pm Glucosamine/chondroitin 10pm Calcium *I struggle to remember the afternoon T3 dose as despite phone alerts,
bikebabe
in
Thyroid UK
11 months ago
A little change
Interested in any comments about Faslodex, although I had none of the suggested bad side effects for letrozole or
palbociclib
.
Interested in any comments about Faslodex, although I had none of the suggested bad side effects for letrozole or
palbociclib
.
Beryl71
in
SHARE Metastatic Breast Cancer
10 months ago
Real-world study of overall survival with palbociclib plus aromatase inhibitor in HR+/HER2− metastatic breast cancer
These data support first-line
palbociclib
plus an AI treatment for HR+/HER2− MBC.
These data support first-line
palbociclib
plus an AI treatment for HR+/HER2− MBC.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Good end to a long year…
Leterzol and
palbociclib
was no longer working. In the summer I moved to Fasolodex and a second trial drug. I felt okay, but some stomach side effects. In August I discovered it had failed me completely and my growths had doubled. I then caught covid and finally mid September started capcitamone.
Leterzol and
palbociclib
was no longer working. In the summer I moved to Fasolodex and a second trial drug. I felt okay, but some stomach side effects. In August I discovered it had failed me completely and my growths had doubled. I then caught covid and finally mid September started capcitamone.
Glas0824
in
SHARE Metastatic Breast Cancer
1 year ago
HER2-low status may not affect survival outcomes of patients with MBC receiving palbociclib plus ET as frontline therapy.
A
retrospective
study was conducted with "252 consecutive HR+/HER2- MBC patients who received first-line ET plus
palbociclib
at six Italian Oncology Units between March 2016 and June 2021".
A
retrospective
study was conducted with "252 consecutive HR+/HER2- MBC patients who received first-line ET plus
palbociclib
at six Italian Oncology Units between March 2016 and June 2021".
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
Overall Survival With Palbociclib and Fulvestrant in Women With HR+/HER2− Advanced Breast Cancer
The
6-year OS rate
(95% CI) was 19.1% (14.9-23.7) and 12.9% (8.0-19.1) in the
palbociclib
and placebo groups, respectively.
The
6-year OS rate
(95% CI) was 19.1% (14.9-23.7) and 12.9% (8.0-19.1) in the
palbociclib
and placebo groups, respectively.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
metronomic capecitabine (XELODA)
In the last months, after discontinuing
palbociclib
due to toxicity, she has tried everolimus and exemestane but she had to stop after three months due to severe mucositis, despite having tried to decrease the dose.
In the last months, after discontinuing
palbociclib
due to toxicity, she has tried everolimus and exemestane but she had to stop after three months due to severe mucositis, despite having tried to decrease the dose.
Shumawy
in
SHARE Metastatic Breast Cancer
1 year ago
xgeva/Denosumab
I am stable and still on my 1st line of treatment which is
Palbociclib
75mg, letrozole, denosumab and zoladex. Because of low neutrophils I am on a 6 wk cycle, 3weeks on 3 weeks off, with the denosumab being 6 weekly inline with the other treatment which I administer myself.
I am stable and still on my 1st line of treatment which is
Palbociclib
75mg, letrozole, denosumab and zoladex. Because of low neutrophils I am on a 6 wk cycle, 3weeks on 3 weeks off, with the denosumab being 6 weekly inline with the other treatment which I administer myself.
Crazycocker
in
SHARE Metastatic Breast Cancer
1 year ago
Rising ESR1 Mutations During Aromatase Inhibitor and Palbociclib Therapy
[i]
Patients in whom an increase in blood ESR1 mutation levels was detected with no synchronous disease progression were randomised to either continue treatment with first-line aromatase inhibitors and
or switch to fulvestrant and
palbociclib
.
[i]
Patients in whom an increase in blood ESR1 mutation levels was detected with no synchronous disease progression were randomised to either continue treatment with first-line aromatase inhibitors and
or switch to fulvestrant and
palbociclib
.
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
IBrance alternative dosing schedule : (5 on 2 off) another trial in the works
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
In addition, as the half-life of
palbociclib
is 27 hours, 1 week break with the standard 3 weeks on and 1 week off dosing schedule could potentially lead to recovery of Rb phosphorylation during the off week.
Dragonfly2
in
SHARE Metastatic Breast Cancer
2 years ago
timing of medications
These are the full list: Levothyroxine Symbicort puffer
Palbociclib
Letrozole Calcium tabs Vit d3 Vit k Thorne b complex Glucosamine / chondroitin Many thanks (in hopeful anticipation)
These are the full list: Levothyroxine Symbicort puffer
Palbociclib
Letrozole Calcium tabs Vit d3 Vit k Thorne b complex Glucosamine / chondroitin Many thanks (in hopeful anticipation)
bikebabe
in
Thyroid UK
2 years ago
Overall Survival With Palbociclib and Fulvestrant in Women With HR+/HER2− Advanced Breast Cancer
This "updated exploratory analysis" (https://aacrjournals.org/clincancerres/article/28/16/3433/707399/Overall-Survival-with-
Palbociclib
-and-Fulvestrant) indicates: "superior overall survival (OS) outcomes with
palbociclib
plus fulvestrant compared with fulvestrant alone in patients with HR+/HER2− advanced
This "updated exploratory analysis" (https://aacrjournals.org/clincancerres/article/28/16/3433/707399/Overall-Survival-with-
Palbociclib
-and-Fulvestrant) indicates: "superior overall survival (OS) outcomes with
palbociclib
plus fulvestrant compared with fulvestrant alone in patients with HR+/HER2− advanced
Hazelgreen
in
SHARE Metastatic Breast Cancer
2 years ago
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