palbociclib and letrozole

[Wickey20]

hi,

taking palbo and letrozole for last 6 months and few days back gone for pet scan and scan response was good , many places were reduced and not much metabolic activity. So same medicines prescribed, but now suddenly in both legs nerves are paining like shooting pain heavily, will palbociclib or letrozole affect nerves if taken for 6 months?

[Aprilfoolz1]

Have you called your oncologist ? I have been on ibrance and fulvestrant for 4.5 years and have not expected this . I was on lextrozole for 7 years a while back and also didn't have this side effect .

[monkeygirl62]

Please call your oncologist right away, this doesn't sound like a side effect from Ibrance and letrozole but you never know. As I am on both for the same amount of time as you and I haven't had this as a side effect. What you are describing sounds a lot like neuropathy, I have neuropathy in my left arm and hand from tumors pressing on the nerves. I have sharp shooting pains like that and I take medicine for my neuropathy. I am so sorry this is happening to you 😭 because I know it hurts and really hard to sleep 😴 with the pain. Hugs 🤗 and prayers 🙏 for speedy resolution to this issue for you. Alicia

[Wickey20 in reply to monkeygirl62]

sure but just 4 days back did pet scan and there was no bone mets. So within 4 days will it spread? Thanks for your response between

[Wickey20 in reply to Wickey20]

Also just an question, if bone mets are there calcium levels will be more in blood if am not wrong?. But recent blood test shows calcium level normal as 8.9.

[Discocat]

Hi

I'm on same meds for 3 years now.

I have extensive bone mets but the meds have stabilized them....and my primary tumour in right breast is now undetectable.

In my experience the Letrozole can cause all sorts of aches and pains.

Mine are in the bone sockets more...hips mostly.

I've had nerve twinges too. Mostly I've found that the pains shift about and don't stay in the same spot for long.

Exercise helps.

To answer a few of your questions...neuropathy is a nerve condition...its not connected to met activity, but can be a side effect from Ibrance.

Calcium levels can change at various times during treatments... if your having IV infusions of Zometa for instance.

I take a daily sup of Calcium/D3 that my oncologist prescribed.

Wishing you all the best

Zoe

[TwithBC]

… I have had the strangest pains that’s come and go on letrozole for 7 years; nerve pains in legs, back, joint locking up … come and go over the years; I’m currently without any pain at all…so odd. But yeah, I had inner thigh nerve pain at one time that was so odd and painful couldn’t turn in my bed … this may not be the case for you; but chiming in to say…yes I have… this was posted a month ago….has the pain subsided: did you see a doctor?