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Glycine + N-acetylcysteine
In a recent thread, the dangers of antioxidant supplementation were illuminated. Excess levels of antioxidants interfere with normal homeostasis and the body´s own mechanisms of fighting cancer. By depleting ROS, one´s ability to destroy cancer cells declines. Particular mention was made of glutathione
In a recent thread, the dangers of antioxidant supplementation were illuminated. Excess levels of antioxidants interfere with normal homeostasis and the body´s own mechanisms of fighting cancer. By depleting ROS, one´s ability to destroy cancer cells declines. Particular mention was made of glutathione
Purple-Bike
in
Advanced Prostate Cancer
2 years ago
Cortexyme presented new data from their Phase II/III GAIN trial of atuzaginstat in mild/moderate Alzheimers
-2022-demonstrating-potential-benefit-of-
lysine
-gingipain-inhibition-in-mild-to-moderate-alzheimers-population/ https://twitter.com/ScienceofPD/status/1506002353597603841
-2022-demonstrating-potential-benefit-of-
lysine
-gingipain-inhibition-in-mild-to-moderate-alzheimers-population/ https://twitter.com/ScienceofPD/status/1506002353597603841
Hidden
in
Cure Parkinson's
2 years ago
NAC supp continued
I'll continue the NAC+
Lysine
for now.
I'll continue the NAC+
Lysine
for now.
EPguy
in
MPN Voice
2 years ago
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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
PRC2 is located at histone 3
lysine
27 (H3K27), and H3K27 trimethylation (H3K27me3) is the key mechanism for transcriptional repression (Ferrari et al., 2014). EZH2 is up-regulated in a variety of cancer types, such as breast, colorectal, and prostate cancer.
PRC2 is located at histone 3
lysine
27 (H3K27), and H3K27 trimethylation (H3K27me3) is the key mechanism for transcriptional repression (Ferrari et al., 2014). EZH2 is up-regulated in a variety of cancer types, such as breast, colorectal, and prostate cancer.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Salmon Protein Hydrolysate
It contains particularly high amounts of glutamic acid (13.9 g/100 g), aspartic acid (9.4 g/100 g), glycine (14.9 g/100 g), proline (7.6 g/100 g),
lysine
(7.0 g/100 g), alanine (7.5 g/100 g) and arginine (6.9 g/100 g).
It contains particularly high amounts of glutamic acid (13.9 g/100 g), aspartic acid (9.4 g/100 g), glycine (14.9 g/100 g), proline (7.6 g/100 g),
lysine
(7.0 g/100 g), alanine (7.5 g/100 g) and arginine (6.9 g/100 g).
pjoshea13
in
Advanced Prostate Cancer
2 years ago
IBS general: my experience
This smell of rotting flesh comes from the amino acids
lysine
and arginine being metabolized by bad colonic bacteria into cadaverine and putrescine – the compounds that give the characteristic smell of death!
This smell of rotting flesh comes from the amino acids
lysine
and arginine being metabolized by bad colonic bacteria into cadaverine and putrescine – the compounds that give the characteristic smell of death!
Stuart24
in
IBS Network
2 years ago
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
I have stayed away from this topic, but so many have posted & I don't think a link to the actual paper has been given. Apologies if not the case. Anyway, https://pubmed.ncbi.nlm.nih.gov/35450835/
Eur Urol Oncol
. 2022 Apr 18;S2588-9311(22)00056-6. doi: 10.1016/j.euo.2022.03.006. Online ahead
I have stayed away from this topic, but so many have posted & I don't think a link to the actual paper has been given. Apologies if not the case. Anyway, https://pubmed.ncbi.nlm.nih.gov/35450835/
Eur Urol Oncol
. 2022 Apr 18;S2588-9311(22)00056-6. doi: 10.1016/j.euo.2022.03.006. Online ahead
pjoshea13
in
Advanced Prostate Cancer
2 years ago
The Role Of Bile Acids In Prostate Cancer
Bile acids (BAs) belong to cholesterol-derived sterols. Due to the side chain carboxyl group and hydroxylation of their steroid ring they are more polar than cholesterol. They have an amphipatic character for which they are known as natural detergents. Majority of cholesterol is excreted by bile acids
Bile acids (BAs) belong to cholesterol-derived sterols. Due to the side chain carboxyl group and hydroxylation of their steroid ring they are more polar than cholesterol. They have an amphipatic character for which they are known as natural detergents. Majority of cholesterol is excreted by bile acids
Hidden
in
Advanced Prostate Cancer
2 years ago
Low-carb diet - ketogenesis - PSADT
New study from Steve Freedland et al. "
Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial
" [1] Bottom line: Low-carb diet may lenghthen
New study from Steve Freedland et al. "
Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial
" [1] Bottom line: Low-carb diet may lenghthen
pjoshea13
in
Advanced Prostate Cancer
2 years ago
A Wise Person Told Me to Not Forget About TUDCA
Bile Acid Signaling in Neurodegenerative and Neurological Disorders 2020 https://mdpi-res.com/d_attachment/ijms/ijms-21-05982/article_deploy/ijms-21-05982.pdf "4.2. Parkinson’s Disease After AD, Parkinson’s disease (PD) is the second most common neurodegenerative disease marked by progressive motor deterioration
Bile Acid Signaling in Neurodegenerative and Neurological Disorders 2020 https://mdpi-res.com/d_attachment/ijms/ijms-21-05982/article_deploy/ijms-21-05982.pdf "4.2. Parkinson’s Disease After AD, Parkinson’s disease (PD) is the second most common neurodegenerative disease marked by progressive motor deterioration
Bolt_Upright
in
Cure Parkinson's
2 years ago
The Neuroendocrine Connection
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
SilentEchoes
in
Cure Parkinson's
2 years ago
Re-Expression of ... AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition. Lithium?
https://pubmed.ncbi.nlm.nih.gov/35402240/ [2] https://en.wikipedia.org/wiki/GSK-3#cite_note-pmid31553649-39 [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038888/ [4] https://www.urotoday.com/conference-highlights/suo-2018/suo-2018-prostate-cancer/108879-suo-2018-lithium-treatment-alters-histone-
lysine
-modification-in-prostate-cancers.html
https://pubmed.ncbi.nlm.nih.gov/35402240/ [2] https://en.wikipedia.org/wiki/GSK-3#cite_note-pmid31553649-39 [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038888/ [4] https://www.urotoday.com/conference-highlights/suo-2018/suo-2018-prostate-cancer/108879-suo-2018-lithium-treatment-alters-histone-
lysine
-modification-in-prostate-cancers.html
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson’s disease
Box plot showing levels of representative metabolites in normal controls (CON), early-stage PD (EPD), mid-stage PD (MPD) and advanced-stage PD (APD). (A) leucine, (B) isoleucine, (C) glycine, (D) cortisol, (E) dihydrocortisol, (F) kynurenine, (G) phenylalanine; (H) acetylphenylalanine. Asterisk(*) denotes
Box plot showing levels of representative metabolites in normal controls (CON), early-stage PD (EPD), mid-stage PD (MPD) and advanced-stage PD (APD). (A) leucine, (B) isoleucine, (C) glycine, (D) cortisol, (E) dihydrocortisol, (F) kynurenine, (G) phenylalanine; (H) acetylphenylalanine. Asterisk(*) denotes
Bolt_Upright
in
Cure Parkinson's
2 years ago
Besremi versus Pegasys
Further for Pegasys there are several different sites to which PEG can attach, I assume this is the "moieties" noted above: https://www.sciencedirect.com/topics/medicine-and-dentistry/peginterferon-alpha2a <<There are four main potential IFN-α2a pegylation sites, (for Pegasys) at
lysine
positions 31
Further for Pegasys there are several different sites to which PEG can attach, I assume this is the "moieties" noted above: https://www.sciencedirect.com/topics/medicine-and-dentistry/peginterferon-alpha2a <<There are four main potential IFN-α2a pegylation sites, (for Pegasys) at
lysine
positions 31
EPguy
in
MPN Voice
3 years ago
"Low oxalate" may be the only true solution
Before you read the following please take a moment and imagine how frustrating it is for someone to have figured out a non-medical treatment for RLS and then had very little luck getting anybody to listen to him. Every day this website carries stories of needless suffering and it breaks my heart. For
Before you read the following please take a moment and imagine how frustrating it is for someone to have figured out a non-medical treatment for RLS and then had very little luck getting anybody to listen to him. Every day this website carries stories of needless suffering and it breaks my heart. For
notnowdad
in
Restless Legs Syndrome
2 years ago
Sirtuins and Pd
SIRTs have been implicated in gene and metabolic regulation through their capacity to remove acyl groups from
lysine
residues in proteins in an NAD+-dependent manner, which may alter individual protein properties as well as the histone–DNA interaction.
SIRTs have been implicated in gene and metabolic regulation through their capacity to remove acyl groups from
lysine
residues in proteins in an NAD+-dependent manner, which may alter individual protein properties as well as the histone–DNA interaction.
Gioc
in
Cure Parkinson's
3 years ago
Supplements for C-myelopathy
I added other supplements like
lysine
, tyrosine, phosphatidyl choline and Vit. E, D, krill oil, zinc, etc. and without these energy and ataxia are much worse. I just joined so wanting to know if anyone is taking something that really makes a difference esp. with lack of oxygen in the brain.
I added other supplements like
lysine
, tyrosine, phosphatidyl choline and Vit. E, D, krill oil, zinc, etc. and without these energy and ataxia are much worse. I just joined so wanting to know if anyone is taking something that really makes a difference esp. with lack of oxygen in the brain.
rideabike
in
Cervical Myelopathy
3 years ago
Possible explanation for lack of hepatic B12 storage
I've seen a few posts on this forum regarding the seemingly inexplicable variations in B12 dosing schedules needed to keep different individuals from experiencing signs of deficiency. Furthermore, it seems that every MD believes one should store enough B12 in the liver for lengthy periods of time without
I've seen a few posts on this forum regarding the seemingly inexplicable variations in B12 dosing schedules needed to keep different individuals from experiencing signs of deficiency. Furthermore, it seems that every MD believes one should store enough B12 in the liver for lengthy periods of time without
USmedsyssucks
in
Pernicious Anaemia Society
3 years ago
Who Wants to Make the Case for UDCA/TUDCA?
Now that I've dropped Glycine CC suggested I focus on TUDCA. Turns out I had tried and stopped TUDCA but circling back it looks like I should have kept it up! The questions I'd like to answer in this thread are: 1: Should I be taking TUDCA and why/why not? 2: How much TUDCA should I be taking? PS: I
Now that I've dropped Glycine CC suggested I focus on TUDCA. Turns out I had tried and stopped TUDCA but circling back it looks like I should have kept it up! The questions I'd like to answer in this thread are: 1: Should I be taking TUDCA and why/why not? 2: How much TUDCA should I be taking? PS: I
Bolt_Upright
in
Cure Parkinson's
3 years ago
Time to Cut Glycine from my Stack? (this would include GlyNAC)
So I was perusing the Rhyothemis blog http://rhyobrain.blogspot.com and stumbled across something concerning "Hcy neurological harm depends on glycine levels" https://rhyobrain.blogspot.com/2021/05/homocysteine-cbs-autoimmunity-very.html which led me to this: The Controversial Role of Homocysteine in
So I was perusing the Rhyothemis blog http://rhyobrain.blogspot.com and stumbled across something concerning "Hcy neurological harm depends on glycine levels" https://rhyobrain.blogspot.com/2021/05/homocysteine-cbs-autoimmunity-very.html which led me to this: The Controversial Role of Homocysteine in
Bolt_Upright
in
Cure Parkinson's
3 years ago
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