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Proteolysis-Targeting Chimeras (PROTACs): targeting cancer by deleting deleterious proteins?
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
There seem to be a kind of superiority of PROTACs over conventional inhibitors in treating prostate cancer. The article examines various targets for PROTACs in prostate cancer, including the androgen receptor and other critical oncoproteins, while addressing future prospects and challenges in this
Maxone73
in
Advanced Prostate Cancer
8 months ago
High Cholesterol
Hi everyone, this is my first post. I have been experiencing symptoms of underactive thyroid and requested a blood test to look into it (this was done 2 days ago). I got a text message last night saying my routine blood test shows I have high cholesterol and advise going on statins. No mention of my
Hi everyone, this is my first post. I have been experiencing symptoms of underactive thyroid and requested a blood test to look into it (this was done 2 days ago). I got a text message last night saying my routine blood test shows I have high cholesterol and advise going on statins. No mention of my
RedorBed
in
Thyroid UK
5 months ago
kidney stones
The doctor has said I could have kidney stones but because the pain is very mild it’s not an immediate concern as it’s the weekend. I should try and ride it out until my blood tests and scan next week unless it gets severe.
The doctor has said I could have kidney stones but because the pain is very mild it’s not an immediate concern as it’s the weekend. I should try and ride it out until my blood tests and scan next week unless it gets severe.
Kimbad1990
in
Early CKD Support
8 months ago
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Cardioversion with amiodarone or straight to ablation?
CV 24/2 failed after 1 week. Heart function team suggest course of amiodarone combined with further CV after a few months of this medication. They have left it with me to consider what I would prefer to do. Either proceed with the above ( with a list of potential side effects which are impossible
CV 24/2 failed after 1 week. Heart function team suggest course of amiodarone combined with further CV after a few months of this medication. They have left it with me to consider what I would prefer to do. Either proceed with the above ( with a list of potential side effects which are impossible
Hallane
in
Atrial Fibrillation Support
4 months ago
Commenced Bisoprolol
Hi I suffer from Paroxysmal AF. I have been taking Rivaroxaban for 2 months. I saw the cardiologist and he has started me on 2.5mg Bisoprolol daily. I took my first dose at 10am and by 2.30pm my Heart Rate had dropped to 50 bpm. My question is to others who take Bisoprolol for rhythm control and who
Hi I suffer from Paroxysmal AF. I have been taking Rivaroxaban for 2 months. I saw the cardiologist and he has started me on 2.5mg Bisoprolol daily. I took my first dose at 10am and by 2.30pm my Heart Rate had dropped to 50 bpm. My question is to others who take Bisoprolol for rhythm control and who
Cat715
in
Atrial Fibrillation Support
4 months ago
Has anyone with Hashimoto or any other autoimmune condition tried low dose naltrexone ( NDL) to regulate autoimmune response?
I have multiple autoimmune diseases, such as Hashimoto, autoimmune gastritis and Reynolds. The list is growing. I am already on clean diet and manage my stress as much as I can and need to try something more than that. I have read the LDN research and keen to try. I understand it isn't a panacea
I have multiple autoimmune diseases, such as Hashimoto, autoimmune gastritis and Reynolds. The list is growing. I am already on clean diet and manage my stress as much as I can and need to try something more than that. I have read the LDN research and keen to try. I understand it isn't a panacea
sasha_nico
in
Thyroid UK
5 months ago
eating gluten prior to biopsy
Hi, I was diagnosed with coeliac disease a few years ago during covid. At that time (lockdown), the second stage of diagnosis was suspended. In my case, my blood results and the fact that I have first degree relatives with coeliac disease and I also have thyroid disease all combined to mean there was
Hi, I was diagnosed with coeliac disease a few years ago during covid. At that time (lockdown), the second stage of diagnosis was suspended. In my case, my blood results and the fact that I have first degree relatives with coeliac disease and I also have thyroid disease all combined to mean there was
lauram1978
in
Gluten Free Guerrillas
7 months ago
nail problems
Does anyone have problems with the nails on their hands? The sides of three of my nails are rough and breaking away from finger. I do have Raynauds and Scleroderma as well as Rheumatoid Arthritis lucky me! Sheena C
Does anyone have problems with the nails on their hands? The sides of three of my nails are rough and breaking away from finger. I do have Raynauds and Scleroderma as well as Rheumatoid Arthritis lucky me! Sheena C
SheenaC
in
Scleroderma & Raynaud's UK (SRUK)
5 months ago
Signatera tumor dna test
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
Has anyone heard of using the Signatera test from Natera to detect the presence of prostate cancer recurrence when PSA is rising but the PSMA PET scan is negative?
shihtzu124
in
Advanced Prostate Cancer
8 months ago
PSA Dropped after 22 days of Zytiga
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
On Nov 1, my cancer was diagnosed as castrate resistant. Abiraterone and Prednisone was added to Lupron. On November 3 I had a Lupron shot and started Abiraterone and Prednisone on November 10. Today I had a PSA test. My PSA dropped from 0.8 on November 1 to 0.44 today. I was not expecting such dramatic
dac500
in
Advanced Prostate Cancer
8 months ago
Final Path Report After RALP (Dad - 74, G7- 4+3) , what’s next ?
Hi All, I had posted about a month ago about my dad with G7 - 4+ 3. We originally thought there were bone Mets but it just turned out to be another bone anomaly identified in the PSMA PET scan. We went ahead with RALP and have shared the final path report here. While the MRI showed no signs of
Hi All, I had posted about a month ago about my dad with G7 - 4+ 3. We originally thought there were bone Mets but it just turned out to be another bone anomaly identified in the PSMA PET scan. We went ahead with RALP and have shared the final path report here. While the MRI showed no signs of
EzioAudi7
in
Advanced Prostate Cancer
8 months ago
Treadmill test
As an aid to diagnosing persistent chest pains - the consultant thinks they are non-cardiac but wants to investigate a bit more-I’m to be given a treadmill test in a few weeks. I asked for this instead of the more rigourous but not very pleasant “stress test”. The heart rate will be raised to 100 during
As an aid to diagnosing persistent chest pains - the consultant thinks they are non-cardiac but wants to investigate a bit more-I’m to be given a treadmill test in a few weeks. I asked for this instead of the more rigourous but not very pleasant “stress test”. The heart rate will be raised to 100 during
Samazeuilh2
in
Atrial Fibrillation Support
4 months ago
Low dose <5mg eliquis
I am taking Eliquis 5 mg twice a day. I get some significant bruising. I am also taking ibrutinib 140 mg which is lowest dose...blood counts are good. I was also diagnosed with afib. I'm wondering if anyone is taking less than 5 mg Eliquis twice daily and if that works? I've talked with a couple friends
I am taking Eliquis 5 mg twice a day. I get some significant bruising. I am also taking ibrutinib 140 mg which is lowest dose...blood counts are good. I was also diagnosed with afib. I'm wondering if anyone is taking less than 5 mg Eliquis twice daily and if that works? I've talked with a couple friends
Bobsterguy
in
Atrial Fibrillation Support
4 months ago
Worried about these results please help
Had this blood test done in January and had text to say book a non urgent appointment and just put it off also getting print out from docs they’ve requested a telephone consultation which I’ve eventually booked but looking at it I know the TSH is low in their opinion and obviously cholesterol too high
Had this blood test done in January and had text to say book a non urgent appointment and just put it off also getting print out from docs they’ve requested a telephone consultation which I’ve eventually booked but looking at it I know the TSH is low in their opinion and obviously cholesterol too high
Silverlady5
in
Thyroid UK
5 months ago
Arrhythmias
Hi Everyone,I have Afib, 1st episode in December 2022 resolved by cardioversion followed by 2 episodes in July 2023, lasting 24 and 12 hours respectively. I am currently on 1.25 bisoporal daily. Over recent nights I have been getting arrhythmias which my scan watch and omron devices don't classify as
Hi Everyone,I have Afib, 1st episode in December 2022 resolved by cardioversion followed by 2 episodes in July 2023, lasting 24 and 12 hours respectively. I am currently on 1.25 bisoporal daily. Over recent nights I have been getting arrhythmias which my scan watch and omron devices don't classify as
Wilkie1
in
Atrial Fibrillation Support
5 months ago
fluoxetine
hi So I’ve asked before about Fluoxetine as treatment for my raynauds I’ve been told it’s extreme primary although they haven’t ruled out secondary. I’m anxious of taking drugs and wondered what experience anyone has had with fluoxetine. Effectiveness, side effects and is alcohol ok? Thanks all
hi So I’ve asked before about Fluoxetine as treatment for my raynauds I’ve been told it’s extreme primary although they haven’t ruled out secondary. I’m anxious of taking drugs and wondered what experience anyone has had with fluoxetine. Effectiveness, side effects and is alcohol ok? Thanks all
Enjoyswalking
in
Scleroderma & Raynaud's UK (SRUK)
5 months ago
cardioversion and Flecainide
An update - I had my cardioversion privately a week ago - all good, so far….. I feel so much better. HR now around 55-60 instead of 90-100 ( on high dose drugs) I was immediately taken off Digoxin and told to continue the BB Nebivolol 10mg a day. Then started on Flecainide 100mg daily, with the BB.
An update - I had my cardioversion privately a week ago - all good, so far….. I feel so much better. HR now around 55-60 instead of 90-100 ( on high dose drugs) I was immediately taken off Digoxin and told to continue the BB Nebivolol 10mg a day. Then started on Flecainide 100mg daily, with the BB.
Canteringon
in
Atrial Fibrillation Support
5 months ago
Recommendations for Endos in/near Berkshire
Just wondered if anyone has any recommendations for endos in or around Berkshire if they could pm me. I have seen one recently who has said he doesn't think I've ever had a thyroid problem as I was borderline when diagnosed but still have many symptoms. My TSH is very low but I am on a combination
Just wondered if anyone has any recommendations for endos in or around Berkshire if they could pm me. I have seen one recently who has said he doesn't think I've ever had a thyroid problem as I was borderline when diagnosed but still have many symptoms. My TSH is very low but I am on a combination
JRosemaryW
in
Thyroid UK
5 months ago
Hashimoto's & Multiple Sclerosis (apologies for two posts in very quick succession!)
Hello - first off, sorry for making two posts in quick succession asking for help! As I mentioned in my first question about an Endo Department, there has been a 'twist' in my Hashi's (I actually have Ord's: autoimmune thyroid disease with no goitre) story... Over the course of several blood tests,
Hello - first off, sorry for making two posts in quick succession asking for help! As I mentioned in my first question about an Endo Department, there has been a 'twist' in my Hashi's (I actually have Ord's: autoimmune thyroid disease with no goitre) story... Over the course of several blood tests,
ERIC107
in
Thyroid UK
5 months ago
Methotrexate
Been on methotrexate 15mg for 16 wks have psoriatic arthritis, rheumatoid arthritis helps my nails n skin but my joint feel worse now was out on another 5 mg from last Monday fell dreadfully n breathless n more pain n my feet and feel my blood vessels all tight n pulling any body else have this
Been on methotrexate 15mg for 16 wks have psoriatic arthritis, rheumatoid arthritis helps my nails n skin but my joint feel worse now was out on another 5 mg from last Monday fell dreadfully n breathless n more pain n my feet and feel my blood vessels all tight n pulling any body else have this
Teddie111
in
NRAS
5 months ago
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