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Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with CLL
[/i] [i]Ibrutinib was given orally for 7 days, then up to six 28-day cycles were administered intravenously of
fludarabine
, cyclophosphamide and rituximab with continuous oral ibrutinib (420 mg/day).
[/i] [i]Ibrutinib was given orally for 7 days, then up to six 28-day cycles were administered intravenously of
fludarabine
, cyclophosphamide and rituximab with continuous oral ibrutinib (420 mg/day).
Jm954
Administrator
in
CLL Support
4 years ago
FCR oral versus iv
Hi I have read that cyclophosphamide and
fludarabine
can be given orally instead of IV. Is oral better tolerated in terms side effects? I guess oral formulation avoids need to attend hospital more frequently for infusions too. Is there anything else I should consider if needing tx with FCR? Thanks
Hi I have read that cyclophosphamide and
fludarabine
can be given orally instead of IV. Is oral better tolerated in terms side effects? I guess oral formulation avoids need to attend hospital more frequently for infusions too. Is there anything else I should consider if needing tx with FCR? Thanks
CarpeDiem03
in
CLL Support
4 years ago
Antibodies test CLL
I had my yearly appointment with the haematologist over the phone yesterday. I explained that I am worried about covid and cll as I am still prone to getting sinusitis which then sometimes ends up with chest infection. Also have some minor other issues. She then said that I should have an antibodies
I had my yearly appointment with the haematologist over the phone yesterday. I explained that I am worried about covid and cll as I am still prone to getting sinusitis which then sometimes ends up with chest infection. Also have some minor other issues. She then said that I should have an antibodies
Ellebele
in
CLL Support
4 years ago
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NICE approves venetoclax with obinutuzumab for patients with untreated CLL
Great news for patients in England and Wales as The National Institute for Health and Care Excellence (NICE) have made recommendations for venetoclax plus obinutuzumab as an option for treating chronic lymphocytic leukaemia (CLL).
Which group of patients can access this new treatment?
It is recommended
Great news for patients in England and Wales as The National Institute for Health and Care Excellence (NICE) have made recommendations for venetoclax plus obinutuzumab as an option for treating chronic lymphocytic leukaemia (CLL).
Which group of patients can access this new treatment?
It is recommended
HAIRBEAR_UK
in
Leukaemia Support
4 years ago
In remission after FCR treatment for CLL 7yrs ago. Should I be shielding because of Covid? I did not have a letter from my GP. I am 63yrs.
Now in a household with 2 frontline health workers.
Now in a household with 2 frontline health workers.
Jessian2
in
CLL Support
4 years ago
V+O or FCR
Hi folks, I've been reading your posts for some time, but due to a lack of experience, I haven't been able to provide a response myself. but now I would like to ask your advice. briefly about the background: my husband was diagnosed in 2015 and has been on w & w since then. Due to a slowly but steadily
Hi folks, I've been reading your posts for some time, but due to a lack of experience, I haven't been able to provide a response myself. but now I would like to ask your advice. briefly about the background: my husband was diagnosed in 2015 and has been on w & w since then. Due to a slowly but steadily
Germanguest
in
CLL Support
4 years ago
Pneumococcal vaccine
Hello all. I had the pneumococcal vaccine two or three years ago, then had FCR chemotherapy which finished in October 2018. I’ve been invited for a second pneumococcal jab next week. My haematologist is aware. I thought I’d check to see if anyone else has done the same, and if there’s any reason I shouldn
Hello all. I had the pneumococcal vaccine two or three years ago, then had FCR chemotherapy which finished in October 2018. I’ve been invited for a second pneumococcal jab next week. My haematologist is aware. I thought I’d check to see if anyone else has done the same, and if there’s any reason I shouldn
Graham2222
in
CLL Support
4 years ago
fatigue
Hi again. Different topic - fresh post. So here I am 2yrs and 4 mths post FCR (6 cycles) and several months of bone marrow not producing red cells (recovered from that 8mths ago) and I'm still struggling with erratic and intermittent debilitating fatigue. I understand this affects different cancer groups
Hi again. Different topic - fresh post. So here I am 2yrs and 4 mths post FCR (6 cycles) and several months of bone marrow not producing red cells (recovered from that 8mths ago) and I'm still struggling with erratic and intermittent debilitating fatigue. I understand this affects different cancer groups
Jotame
in
CLL Support
4 years ago
Myelodyplastic Syndrome (MDS)
Hi. In my previous post I wrote about reaching a point 18months after completing FCR where my bone marrow stopped producing red cells. This got a diagnosis of MDS which was expected to be irreversible. After several months and 6 blood transfusions I'm thrilled to say my marrow is back in action and
Hi. In my previous post I wrote about reaching a point 18months after completing FCR where my bone marrow stopped producing red cells. This got a diagnosis of MDS which was expected to be irreversible. After several months and 6 blood transfusions I'm thrilled to say my marrow is back in action and
Jotame
in
CLL Support
4 years ago
Younger, Fit Patients With CLL: Goal Remains Undetectable Minimal Residual Disease and Time-Limited Therapy
This article looks at the interim analysis of E1912, a U.S. randomized phase III trial comparing ibrutinib/rituximab, followed by ibrutinib to disease progression vs 6 months of FCR among patients withCLL younger than age 70. [i]"Although the study was not stratified by IgHV mutation status, the results
This article looks at the interim analysis of E1912, a U.S. randomized phase III trial comparing ibrutinib/rituximab, followed by ibrutinib to disease progression vs 6 months of FCR among patients withCLL younger than age 70. [i]"Although the study was not stratified by IgHV mutation status, the results
Jm954
Administrator
in
CLL Support
4 years ago
Time-to-progression after front-line FCR for CLL: a retrospective, multicohort study
It has been known for some time that FCR can produce very long remissions (perhaps cures) for some patients with mutated CLL. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760129/ This study looks at unmutated patients and could be an important study for CLL patients or, on the other hand, completely
It has been known for some time that FCR can produce very long remissions (perhaps cures) for some patients with mutated CLL. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760129/ This study looks at unmutated patients and could be an important study for CLL patients or, on the other hand, completely
Jm954
Administrator
in
CLL Support
4 years ago
Duvelisib + FCR (DFCR) frontline therapy for younger CLL patients - study results (Aug. 2020)
"In summary, our phase 1b/2 study identified a recommended phase 2 dose of duvelisib 25 mg bid when given in combination with FCR in younger CLL patients receiving frontline therapy. We observed deep responses, including achievement of BM-uMRD in about two-thirds of patients,irrespective of IGHV mutation
"In summary, our phase 1b/2 study identified a recommended phase 2 dose of duvelisib 25 mg bid when given in combination with FCR in younger CLL patients receiving frontline therapy. We observed deep responses, including achievement of BM-uMRD in about two-thirds of patients,irrespective of IGHV mutation
avzuclav
in
CLL Support
4 years ago
Schematic for CLL treatment?
Is there a decision chart or list of questions somewhere on this forum for how docs make their decisions?(am not talking the nhs system who seem to just offer you fcr to start with as a default regardless as far as I can make out - more like a doc who had all options open). Thanks very much.
Is there a decision chart or list of questions somewhere on this forum for how docs make their decisions?(am not talking the nhs system who seem to just offer you fcr to start with as a default regardless as far as I can make out - more like a doc who had all options open). Thanks very much.
Research123
in
CLL Support
4 years ago
Final treatment free day
I have one last day before starting FCR. The to do list includes a coastal bike ride, a conquer of a hill and the making of a large Sherry trifle plus a full English.* How did you spend that last ‘normal’ day? *Plans subject to change 😊😊(slight 😥 eek)
I have one last day before starting FCR. The to do list includes a coastal bike ride, a conquer of a hill and the making of a large Sherry trifle plus a full English.* How did you spend that last ‘normal’ day? *Plans subject to change 😊😊(slight 😥 eek)
HarryMet
in
CLL Support
4 years ago
SF3B1 Mutations
We've had a couple of members mention that they are positive for SF3B1 Mutations so I thought it would be worth a short simplified post about it. SF3B1 are predominantly sub clonal genetic events in CLL and are not unique to CLL as they are also found in other haematological disease such as myelodysplastic
We've had a couple of members mention that they are positive for SF3B1 Mutations so I thought it would be worth a short simplified post about it. SF3B1 are predominantly sub clonal genetic events in CLL and are not unique to CLL as they are also found in other haematological disease such as myelodysplastic
Jm954
Administrator
in
CLL Support
4 years ago
Does FCR cause hair loss?
Drear group Does FCR cause hairs doss? And is FCR pain full ? Thank you
Drear group Does FCR cause hairs doss? And is FCR pain full ? Thank you
Nour80Leen2011
in
CLL Support
4 years ago
day 1 fcr ,,but un-mutated
hi thankyou for all your replys,well it was day 1 today on fcr everything went smooth day 2 tommorow hope it goes the same ,today i asked the nurse what my mutation was she replayed and said im un-mutated now is it ok to be on fcr if you are unmutated just made me feel a bit worried i asked her before
hi thankyou for all your replys,well it was day 1 today on fcr everything went smooth day 2 tommorow hope it goes the same ,today i asked the nurse what my mutation was she replayed and said im un-mutated now is it ok to be on fcr if you are unmutated just made me feel a bit worried i asked her before
kel555
in
CLL Support
4 years ago
Show I aim to try to walk with this condition
Good morning Looking for advice on walking.... I was diagnosed with CLL November 2019 from a routine blood test. It progressed much quicker than I had expected and by May 2020 as a result of FISH test and 94% 11q deletion, FCR was recommended. However two weeks later I went for routine eye test sent
Good morning Looking for advice on walking.... I was diagnosed with CLL November 2019 from a routine blood test. It progressed much quicker than I had expected and by May 2020 as a result of FISH test and 94% 11q deletion, FCR was recommended. However two weeks later I went for routine eye test sent
Caoimh37
in
Couch to 5K
4 years ago
FCR veterans
hi all iam due to start fcr on the 11 august on flair trial not realy happy due to the covid ,well my question is will it work i have been on w&w for 7yrs i have no tp53 and others and i dont know if iam mutated or un mutated could i be mutated if i have had cll for this long, realy need some answers
hi all iam due to start fcr on the 11 august on flair trial not realy happy due to the covid ,well my question is will it work i have been on w&w for 7yrs i have no tp53 and others and i dont know if iam mutated or un mutated could i be mutated if i have had cll for this long, realy need some answers
kel555
in
CLL Support
4 years ago
FCR
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
Rccfrc00
in
CLL Support
4 years ago
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