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Experiences with
Enzalutamide
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The toilet seat cometh. . . .
In my last post I wrote about the effects of
enzalutamide
on my quality of life. My muscles continue to go rigid when I do not move, so that I wake up with nasty aches. One issue is that of the toilet.
In my last post I wrote about the effects of
enzalutamide
on my quality of life. My muscles continue to go rigid when I do not move, so that I wake up with nasty aches. One issue is that of the toilet.
BrentW
in
Advanced Prostate Cancer
2 years ago
End of Treatment Options? Oncologist says Make Yourself Comfortable Suggestions
ASSESSMENT: -86 year old gentleman with metastatic castrate resistant prostate cancer, rising PSA and worsening lymphadenopathy and new bone mets on
enzalutamide
. Pt also not tolerating full dose
enzalutamide
.
ASSESSMENT: -86 year old gentleman with metastatic castrate resistant prostate cancer, rising PSA and worsening lymphadenopathy and new bone mets on
enzalutamide
. Pt also not tolerating full dose
enzalutamide
.
Willy9173
in
Advanced Prostate Cancer
2 years ago
High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice
Reactivation of androgen signaling in
enzalutamide
-resistant tumors was further shown by the expression of several androgen-dependent genes.
Reactivation of androgen signaling in
enzalutamide
-resistant tumors was further shown by the expression of several androgen-dependent genes.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
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Olaparib Tolerability and the Management of Common Adverse Events in Patients With mCRPC
METHODS Patients were randomized (2:1) to olaparib tablets (300 mg bid) or control (
enzalutamide
or abiraterone) until disease progression or unacceptable toxicity. Safety was assessed through AE reporting and laboratory assessments.
METHODS Patients were randomized (2:1) to olaparib tablets (300 mg bid) or control (
enzalutamide
or abiraterone) until disease progression or unacceptable toxicity. Safety was assessed through AE reporting and laboratory assessments.
Balsam01
in
Advanced Prostate Cancer
2 years ago
Duration of ADT
ESMO 2021: Abiraterone Acetate Plus Prednisolone With or Without
Enzalutamide
Added to ADT Compared to ADT Alone for Men With High-Risk Non-Metastatic Prostate Cancer: Combined Analysis From Two Comparisons in the STAMPEDE Platform
ESMO 2021: Abiraterone Acetate Plus Prednisolone With or Without
Enzalutamide
Added to ADT Compared to ADT Alone for Men With High-Risk Non-Metastatic Prostate Cancer: Combined Analysis From Two Comparisons in the STAMPEDE Platform
hg115pb
in
Advanced Prostate Cancer
2 years ago
Concerning PSMA. Lymph Nodes, Prostate and Bones involvement.
My RO is planning a new round of radiation in two months' time and my MO will start me on
Enzalutamide
in combination with the Decapeptyl. I wondered if anyone has any thoughts on treatment options or experiences in advanced PCa. It would be greatly appreciated.
My RO is planning a new round of radiation in two months' time and my MO will start me on
Enzalutamide
in combination with the Decapeptyl. I wondered if anyone has any thoughts on treatment options or experiences in advanced PCa. It would be greatly appreciated.
Silentio
in
Advanced Prostate Cancer
2 years ago
What should I expect from treatment
What should I be expecting from Radiotherapy I’ve had a good response from initial treatments DX Dec 2021 N0 M1b PSA 102 Zoladex 3 month given 2 weeks after Bicalutamide First PSA reading to give baseline in March 2022 before starting
Enzalutamide
PSA 0.2 Bloods taken again 3 weeks later after
Enzalutamide
What should I be expecting from Radiotherapy I’ve had a good response from initial treatments DX Dec 2021 N0 M1b PSA 102 Zoladex 3 month given 2 weeks after Bicalutamide First PSA reading to give baseline in March 2022 before starting
Enzalutamide
PSA 0.2 Bloods taken again 3 weeks later after
Enzalutamide
Farn
in
Advanced Prostate Cancer
2 years ago
Xtandi for PSMA expression
His oncologist just called, and is starting him on Xtandi (
enzalutamide
) not because he expects it to have much effect on his rapidly advancing disease, but in hopes it will increase PSMA expression and increase the efficacy of the Pluvicto. Should he take the full 160 mg dose?
His oncologist just called, and is starting him on Xtandi (
enzalutamide
) not because he expects it to have much effect on his rapidly advancing disease, but in hopes it will increase PSMA expression and increase the efficacy of the Pluvicto. Should he take the full 160 mg dose?
leebeth
in
Advanced Prostate Cancer
2 years ago
Cognitive Impairment from ADT and Advanced AR Drugs
Neurotoxicity risk was higher with novel ARSIs than traditional agents, and higher with
enzalutamide
than abiraterone.
Neurotoxicity risk was higher with novel ARSIs than traditional agents, and higher with
enzalutamide
than abiraterone.
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Enzo and BAT
Among patients who received
enzalutamide
first, followed by BAT, the response rate to
enzalutamide
was only 23 percent.”
Among patients who received
enzalutamide
first, followed by BAT, the response rate to
enzalutamide
was only 23 percent.”
Hidden
in
Advanced Prostate Cancer
3 years ago
Where to buy affordable Enzalutamide?
Only problem is my dad already has had abiraterone many years ago and I would like to add
enzalutamide
to radium 223 which has been proven safe and more effective. But in the UK this has not been approved so it would not be considered as treatment as far as I know.
Only problem is my dad already has had abiraterone many years ago and I would like to add
enzalutamide
to radium 223 which has been proven safe and more effective. But in the UK this has not been approved so it would not be considered as treatment as far as I know.
Howmuchisthefish
in
Advanced Prostate Cancer
2 years ago
Preventing Drug Resistance - Thinking Outside The Box - PRINT Phase 2 Study
It is titled "Apalutamide, Darolutamide and
Enzalutamide
for Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC): A Critical Review" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997634/ In section 2.7 titled "Not All That Glitters Is Gold" they state: "Despite the exciting results of the SPARTAN
It is titled "Apalutamide, Darolutamide and
Enzalutamide
for Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC): A Critical Review" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997634/ In section 2.7 titled "Not All That Glitters Is Gold" they state: "Despite the exciting results of the SPARTAN
jazj
in
Advanced Prostate Cancer
2 years ago
Trying to avoid the sense that I am on a downward slope
When this failed, about two months ago, I was placed on a strong dose of Xtandi (
enzalutamide
), and the side effects began to pile up. The confusion deepened, and was joined by fatigue, while physical side effects built up too -- fluid retention, aching joints and muscles, tender teeth (!)
When this failed, about two months ago, I was placed on a strong dose of Xtandi (
enzalutamide
), and the side effects began to pile up. The confusion deepened, and was joined by fatigue, while physical side effects built up too -- fluid retention, aching joints and muscles, tender teeth (!)
BrentW
in
Care Community
2 years ago
Pluvicto plus Xtandi
At the beginning of June I started
Enzalutamide
(Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness. On July 7 I called my doc and stopped taking Xtandi and I started feeling better a few days later.
At the beginning of June I started
Enzalutamide
(Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness. On July 7 I called my doc and stopped taking Xtandi and I started feeling better a few days later.
Rondief
in
Advanced Prostate Cancer
2 years ago
Enzalutamide (Xtandi) side effect
I became hormone resistant two months ago and was perscribed
enzalutamide
. While it did hold my PSA down to 0.1, I found the side effects devastating. I was a 7-year veteran, having had radiation HIFU and Zoladex (quarterly), none of which prepared me for my reaction to
enzalutamide
.
I became hormone resistant two months ago and was perscribed
enzalutamide
. While it did hold my PSA down to 0.1, I found the side effects devastating. I was a 7-year veteran, having had radiation HIFU and Zoladex (quarterly), none of which prepared me for my reaction to
enzalutamide
.
CYR7
in
Advanced Prostate Cancer
2 years ago
Dutasteride and Apalutamide
Is there any data available on what percentage of patients become castrate resistant after long term Lupron + Apalutamide/Aberaterone//
Enzalutamide
/Darolutamide? Can triplet therapy be started after long term Lupron and Apalutamide + radiation to prostate? Thanks
Is there any data available on what percentage of patients become castrate resistant after long term Lupron + Apalutamide/Aberaterone//
Enzalutamide
/Darolutamide? Can triplet therapy be started after long term Lupron and Apalutamide + radiation to prostate? Thanks
Squirrel71
in
Advanced Prostate Cancer
2 years ago
Clinical trial using Enzalutamide and Cisplatin
My oncologist has suggested a clinical trial involving
Enzalutamide
and Cisplatin. Right now I am on Lynparza and my PSA has started to rise. Does anyone have any experience or information on this trial?
My oncologist has suggested a clinical trial involving
Enzalutamide
and Cisplatin. Right now I am on Lynparza and my PSA has started to rise. Does anyone have any experience or information on this trial?
Newyork6264
in
Advanced Prostate Cancer
3 years ago
Decision time. Input welcome
Enzalutamide
added to Lupron. 12/3/18 - NM bone scan showed improving uptake in cervical, lower thoracic and upper lumbar spine compared to 12/5/17 study.
Enzalutamide
added to Lupron. 12/3/18 - NM bone scan showed improving uptake in cervical, lower thoracic and upper lumbar spine compared to 12/5/17 study.
Miccoman
in
Advanced Prostate Cancer
2 years ago
Enzalutamide vs Aberaterone
An often mooted question, but from my studies there seems to be more longevity with the Aberaterone with the longest period I’ve read about being 10 years and still going This example is Alfred Samuels where as
Enzalutamide
the longest I’ve heard of is 4years
An often mooted question, but from my studies there seems to be more longevity with the Aberaterone with the longest period I’ve read about being 10 years and still going This example is Alfred Samuels where as
Enzalutamide
the longest I’ve heard of is 4years
Farn
in
Advanced Prostate Cancer
3 years ago
Advanced AR drugs
1.ADT and apalutamide (Erleada) TITAN RCT a.https://www.nejm.org/doi/full/10.1056/nejmoa1903307#:~:text=The%20TITAN%20trial%20was%20a,this%20article%20at%20NEJM.org. 2.ADT and
enzalutamide
(Xtandi) ARCHES RCT a.https://www.cancertherapyadvisor.com/home/news/conference-coverage/esmo-2021/prostate-cancer-
enzalutamide
-adt-prolongs-survival-treatment
1.ADT and apalutamide (Erleada) TITAN RCT a.https://www.nejm.org/doi/full/10.1056/nejmoa1903307#:~:text=The%20TITAN%20trial%20was%20a,this%20article%20at%20NEJM.org. 2.ADT and
enzalutamide
(Xtandi) ARCHES RCT a.https://www.cancertherapyadvisor.com/home/news/conference-coverage/esmo-2021/prostate-cancer-
enzalutamide
-adt-prolongs-survival-treatment
Hidden
in
Advanced Prostate Cancer
3 years ago
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