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Enzalutamide
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After BCR and PSA Return: An Update on My Treatment Path
At the time, I gathered a few second opinions and most top research hospital doctors just recommended intermittent ADT with an anti-androgen (
Enzalutamide
). I chose the heavier path "triple play" (+SBRT and chemo) for a couple of reasons.
At the time, I gathered a few second opinions and most top research hospital doctors just recommended intermittent ADT with an anti-androgen (
Enzalutamide
). I chose the heavier path "triple play" (+SBRT and chemo) for a couple of reasons.
PGDuan
in
Advanced Prostate Cancer
1 year ago
I would like to connect with fellow warriors that are HSPC and on Darolutamide to discuss Time to Failure, early detection assays etc...
Second generation androgen receptor antagonists and challenges in prostate cancer treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304354/ " The utility of these agents has expanded with the emergence of second-generation AR antagonists, which began with the approval of
enzalutamide
in 2012
Second generation androgen receptor antagonists and challenges in prostate cancer treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304354/ " The utility of these agents has expanded with the emergence of second-generation AR antagonists, which began with the approval of
enzalutamide
in 2012
KocoPr
in
Advanced Prostate Cancer
2 years ago
EMBARK trial results reported
[/i] https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-
enzalutamide
-plus-leuprolide
[/i] https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-
enzalutamide
-plus-leuprolide
GP24
in
Advanced Prostate Cancer
2 years ago
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Pluvicto increases radiographic progression-free survival (rPFS) before chemo
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone,
enzalutamide
, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone,
enzalutamide
, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Gut Microbiome, ADT & Doxycycline
." ***" We hypothesized that oral androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
, and abiraterone acetate, may be associated with compositional differences in the GI microbiota."
." ***" We hypothesized that oral androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
, and abiraterone acetate, may be associated with compositional differences in the GI microbiota."
pca2004
in
Fight Prostate Cancer
2 years ago
Lu-177 PNT2002 SPLASH trial
The randomized study (32 weeks) will have arm A and arm B (abiraterone or
enzalutamide
) with crossover eligibility. I am concerned if I get assigned to arm B and moving the possible treatment well too late down the road if I change as requested from Abiraterone to
Enzalutamide
.
The randomized study (32 weeks) will have arm A and arm B (abiraterone or
enzalutamide
) with crossover eligibility. I am concerned if I get assigned to arm B and moving the possible treatment well too late down the road if I change as requested from Abiraterone to
Enzalutamide
.
Ollie1948
in
Advanced Prostate Cancer
2 years ago
CCS 1477 3rd generation AR
it looks as though they’ve created a 3rd generation AR now.For when Aberaterone /
Enzalutamide
runs out of steam. Can a drug be fast tracked onto the market at a 3 year point or do the trials need at least 5 years before being approved does anyone know
it looks as though they’ve created a 3rd generation AR now.For when Aberaterone /
Enzalutamide
runs out of steam. Can a drug be fast tracked onto the market at a 3 year point or do the trials need at least 5 years before being approved does anyone know
Farn
in
Advanced Prostate Cancer
2 years ago
What first?: Provenge or Nubeqa?
Recently approved agents include abiraterone acetate and
enzalutamide
with TAK-700 (orteronel) and lyase inhibitors rapidly approaching in the development pipeline..."
Recently approved agents include abiraterone acetate and
enzalutamide
with TAK-700 (orteronel) and lyase inhibitors rapidly approaching in the development pipeline..."
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
test Enzalutamide or Lu 177 for the first line therapy?
I wonder what is the best treatment to test lowering PSA now,
Enzalutamide
or Lu 177? I appreciate any idea.
I wonder what is the best treatment to test lowering PSA now,
Enzalutamide
or Lu 177? I appreciate any idea.
Samani
in
Advanced Prostate Cancer
2 years ago
BATMAN
Post-BAT, the PSA50 and PSA90 responses to abiraterone or
enzalutamide
were 94.4% and 66.7%, respectively and median PFS was 20.6 months. Patients with peak PSA level of ≥9 ng/ml after BAT had median PFS of 20.6 months versus NR for those having PSA < 9 ng/ml (HR: 0.122, p < 0.001).
Post-BAT, the PSA50 and PSA90 responses to abiraterone or
enzalutamide
were 94.4% and 66.7%, respectively and median PFS was 20.6 months. Patients with peak PSA level of ≥9 ng/ml after BAT had median PFS of 20.6 months versus NR for those having PSA < 9 ng/ml (HR: 0.122, p < 0.001).
pca2004
in
Fight Prostate Cancer
2 years ago
Running out of road....
Then when it escaped the lymph nodes, I was place on shots+
enzalutamide
/Xtandi. I hate that drug, so I was almost relieved that PSA started rising again : 1.7 to 3.3 and evidence of small mets in spine. Because I had to work in Australia for 2 months we did nothing (except I added Propanalol.
Then when it escaped the lymph nodes, I was place on shots+
enzalutamide
/Xtandi. I hate that drug, so I was almost relieved that PSA started rising again : 1.7 to 3.3 and evidence of small mets in spine. Because I had to work in Australia for 2 months we did nothing (except I added Propanalol.
CrocodileShoes
in
Advanced Prostate Cancer
1 year ago
Intracrinology-Revisited and Prostate Cancer
Moreover, indomethacin was found to surmount abiraterone and
enzalutamide
drug resistance in xenograft models over expressing AKR1C3 (71,72). These observations lead to the development of ASP9521 by Astellas.
Moreover, indomethacin was found to surmount abiraterone and
enzalutamide
drug resistance in xenograft models over expressing AKR1C3 (71,72). These observations lead to the development of ASP9521 by Astellas.
KocoPr
in
Fight Prostate Cancer
2 years ago
Keynote trial of Pembrolizumab + Enz+ ADT discontinued
Disappointing results of trial https://www.businesswire.com/news/home/20230124006084/en/Merck-Announces-KEYNOTE-991-Trial-Evaluating-KEYTRUDA%C2%AE-pembrolizumab-Plus-
Enzalutamide
-and-Androgen-Deprivation-Therapy-in-Patients-With-Metastatic-Hormone-Sensitive-Prostate-Cancer-to-Stop-for-Futility
Disappointing results of trial https://www.businesswire.com/news/home/20230124006084/en/Merck-Announces-KEYNOTE-991-Trial-Evaluating-KEYTRUDA%C2%AE-pembrolizumab-Plus-
Enzalutamide
-and-Androgen-Deprivation-Therapy-in-Patients-With-Metastatic-Hormone-Sensitive-Prostate-Cancer-to-Stop-for-Futility
Fightinghard
in
Advanced Prostate Cancer
2 years ago
Docetaxel Extends Enzalutamide Effectiveness
This is our first proof that resistance to
enzalutamide
can be reduced with docetaxel. It also shows that triplet therapy may be beneficial in patients who have already progressed to castration resistance. We would expect a larger effect if used at the first sign of castration resistance.
This is our first proof that resistance to
enzalutamide
can be reduced with docetaxel. It also shows that triplet therapy may be beneficial in patients who have already progressed to castration resistance. We would expect a larger effect if used at the first sign of castration resistance.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-
enzalutamide
-plus-leuprolide
https://www.pfizer.com/news/press-release/press-release-detail/phase-3-study-shows-xtandir-
enzalutamide
-plus-leuprolide
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Cabazitaxel Plus Enzalutamide
Wondering if anyone here has had this combo prescribed and what the results were. There was a phase 1 and phase 2 trial that proved the safety of this combination and they also saw a PSA response 30% or more in 30% of the patients who had previously been treated with Abiraterone. The patients that
Wondering if anyone here has had this combo prescribed and what the results were. There was a phase 1 and phase 2 trial that proved the safety of this combination and they also saw a PSA response 30% or more in 30% of the patients who had previously been treated with Abiraterone. The patients that
EdBacon
in
Advanced Prostate Cancer
2 years ago
Enzalutamide or abiraterone
What is the difference between these two drugs. Which one should I use. I know this was discussed in a post recently. My Oncologist would like me to start with one of these. I asked him this question and said abiraterone has less fatigue side effects. I will need to get blood work done every two weeks
What is the difference between these two drugs. Which one should I use. I know this was discussed in a post recently. My Oncologist would like me to start with one of these. I asked him this question and said abiraterone has less fatigue side effects. I will need to get blood work done every two weeks
Islandboy2021
in
Advanced Prostate Cancer
2 years ago
Advice Please
Enzalutamide
failed after about 6 months. Started docetaxel on Aug 10/22. After 4 cycles, bone scan results, received today, indicate a mixed pattern of response i.e., while many lesions have improved there is also progression in certain lesions as well as new lesions.
Enzalutamide
failed after about 6 months. Started docetaxel on Aug 10/22. After 4 cycles, bone scan results, received today, indicate a mixed pattern of response i.e., while many lesions have improved there is also progression in certain lesions as well as new lesions.
Univs
in
Advanced Prostate Cancer
2 years ago
Enzalutamide just keeps giving and giving: Hot heels
The
enzalutamide
I am taking has made the muscles in my right arm rigid, so it is far too uncomfortable to sleep on that side despite taking the opioid Longtec (40 mg at night). Nor can I sleep on my left side.
The
enzalutamide
I am taking has made the muscles in my right arm rigid, so it is far too uncomfortable to sleep on that side despite taking the opioid Longtec (40 mg at night). Nor can I sleep on my left side.
BrentW
in
Advanced Prostate Cancer
2 years ago
Wa-ah!
I am to continue with my current medication,
enzalutamide
, though at a stronger dose> I am to take morphine to counteract the worst side effect, muscle pain. This will also help with the ache I have in my pelvis, where I had radiation.
I am to continue with my current medication,
enzalutamide
, though at a stronger dose> I am to take morphine to counteract the worst side effect, muscle pain. This will also help with the ache I have in my pelvis, where I had radiation.
BrentW
in
Advanced Prostate Cancer
2 years ago
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