Lu-177 PNT2002 SPLASH trial

[Ollie1948]

After seeing the trial oncologist, I am scheduled to have the required CT scans part of the screening process (up to 6 weeks) of this Lu-177 clinical study.

The randomized study (32 weeks) will have arm A and arm B (abiraterone or enzalutamide) with crossover eligibility. I am concerned if I get assigned to arm B and moving the possible treatment well too late down the road if I change as requested from Abiraterone to Enzalutamide.

If I change to Enzalutamide (Xtandi) during the screening process I need to pay the massive Xtandi bill as my Part D doesn't help that much, especially during the first few months.

Any suggestion to get Xtandi at a lower cost, meaning not through Part D?

[MateoBeach]

I recently researched it inIndia where they have several brands of generic enzalutamide from reputable companies available. Brands include Bdenza and others you can search. Typical prices run around $250 US equivalent per month supply for 112 40mg tablets, plus shipping. Lots of operators there reselling and shipping generics to the US and elsewhere. Do due diligence.

[RyderLake2]

Hi Ollie,

I too am on the SPLASH trial, although I have yet to find out which arm I am being placed on. I was also told if I was placed in Arm B (no Lutetium) I would have to switch from Xtandi (enzalutamide) to Zytiga (abiraterone). This was a concern to me as I have been on Xtandi for over five years. I also didn’t want to make that switch until the randomization process was complete. The clinical trials nurse told us that would not be necessary until my meeting with the clinical trials doctor in mid-November to review my PET scan and find out which arm I am being placed. I think you will find out that you can stay on Zytiga until the screening process is over. Stay in touch. Good luck!

[Leyteisland in reply to RyderLake2]

it looks like on the same or similar boat. I got a call from the specialty pharmacy and ended up clarifying it.... similar to your case. For some reason I thought I would be switching no before the trial.

[RyderLake1 in reply to Leyteisland]

Hello,

I think if you were told that you had to switch (Abi to Xtandi or Xtandi to Abi) before you actually found out what arm of the trial you were on that would essentially predetermine that you would be on Arm B. I don't think the folks at Point Bio-Pharma want that to happen. Do you actually live in the Philippines? If so, truly a small world!

[Leyteisland in reply to RyderLake1]

some confusion here.... As I had replied directly from the cellphone, a new handle was given, LeyteIsland, guess by the system instead of Ollie1948. I live in Texas

[Ollie1948]

some confusion here.... As I had replied directly from the cellphone, a new handle was given, LeyteIsland, guess by the system instead of Ollie1948.... now I am back on my laptop.

[RyderLake2]

Hello Ollie,

Last I looked Texas is nowhere near the Philippines! 😀

[joeguy]

I am also in the SPLASH trial and I got lucky and was put in Arm "A" with the Lu 177. I will be receiving my first dose on 11/10/22. If I had been assigned to Arm "B", I would have been put on Zytiga, because I was already on Xtandi, and had to stop due to side effects. I may be mistaken, but I thought the cost of most everything in this trial was covered by the sponsor. They are paying for my hotels, milage, meals, and as far as I can tell, all of the medical stuff and meds. I guess they may consider the Zytiga or Xtandi as "standard of care" and therefore it would be paid for out of pocket? not sure

[Ollie1948 in reply to joeguy]

I will be getting the scans on Tuesday and Wednesday at UT-SW. Probably they consider Xtandi as Standard Care... if so it will be over $3k a month.

[joeguy in reply to Ollie1948]

we will probably see each other. I am there Wednesday at the new cancer building, and Thursday I’ll be at the POB2 building to get the Lu177 injection. That should be the same building you are getting scanned in. Wonder how many SPLASH trial guys they have?

[Ollie1948 in reply to joeguy]

I will be at the POB2 building on Wednesday. Soon or later we will cross each other. My guess is that will be 3 to 5 guys on our local trial.

[joeguy]

Ollie,

Are you signed up on the UTSW Mychart system? They are really fast about getting test and scan results posted to it. When I was down a few weeks ago, I had bone and CT scans done about 2:00. At 5:30 my wife and I were eating dinner at a restaurant, and the scan results popped up on the Mychart app. I probably should have waited till after dinner to look at the results, because when we read that I had progression and bone mets all over the place, it kind of ruined dinner. But its impressive they had the results to me in a matter of about 3 hours.

[Leyteisland in reply to joeguy]

Yes I am... Also I have the same from MDA. At this phase I am more concerned about the randomization result.

[joeguy in reply to Leyteisland]

yes, I was anxious about the randomization result as well. I was also a little worried if I would light up good enough on the PSMA scan. I got lucky on both counts, and I bet you will too. The odds are in your favor.

[Leyteisland in reply to joeguy]

For some reason, on the cell I became LeyteIsland instead of Ollie1148