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Apalutamide for Metastatic Castration-Sensitive Prostate Cancer
The study allowed for previous treatment for localized disease and previous
docetaxel
therapy. The radiographic progression–free survival at 24 months was 68.2% in the apalutamide group and 47.5% in the placebo group (HR for radiographic progression or death, 0.48).
The study allowed for previous treatment for localized disease and previous
docetaxel
therapy. The radiographic progression–free survival at 24 months was 68.2% in the apalutamide group and 47.5% in the placebo group (HR for radiographic progression or death, 0.48).
snoraste
in
Advanced Prostate Cancer
5 years ago
Both apalutamide and enzalutamide succeed for metastatic hormone-sensitive prostate cancer (mHSPC) - enzalutamide not for high volume mets
New info presented this morning at ASCO - Enzalutamide (Xtandi) worked best in men with mHSPC with a [i]low[/i] volume of mets, and in men who did [i]not[/i] plan to have early
docetaxel
(which is probably much the same thing). Apalutamide worked well regardless of high or low volume of mets.
New info presented this morning at ASCO - Enzalutamide (Xtandi) worked best in men with mHSPC with a [i]low[/i] volume of mets, and in men who did [i]not[/i] plan to have early
docetaxel
(which is probably much the same thing). Apalutamide worked well regardless of high or low volume of mets.
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
Docetaxel
My first session took me 10 days to the hospital for an important sepsis. The second one I made 8 days ago. The only side effect has been a great fatigue that started on day 3. Today on day 8 it persists. A lot of weakness, fatigue and thick head. It is normal?
My first session took me 10 days to the hospital for an important sepsis. The second one I made 8 days ago. The only side effect has been a great fatigue that started on day 3. Today on day 8 it persists. A lot of weakness, fatigue and thick head. It is normal?
joancarles
in
Advanced Prostate Cancer
5 years ago
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Docetaxel 2 week cycle
Has anyone taken
docetaxel
on a 2 week cycle at 50 mg vs the traditional 3 week cycle at 75 mg? I have read that it has less side effects.
Has anyone taken
docetaxel
on a 2 week cycle at 50 mg vs the traditional 3 week cycle at 75 mg? I have read that it has less side effects.
cancerking
in
Advanced Prostate Cancer
5 years ago
Has anyone taken Docetaxel
Has anyone taken
docetaxel
? And what where the effects? And do you take it on its own or with something else? It seems that a clinical trial was done in vitro with
docetaxel
and curcumin which showed that the tumor was shrinking more with curcumin added.
Has anyone taken
docetaxel
? And what where the effects? And do you take it on its own or with something else? It seems that a clinical trial was done in vitro with
docetaxel
and curcumin which showed that the tumor was shrinking more with curcumin added.
dieneke
in
My Ovacome
5 years ago
What to Ask?
He’s done
Docetaxel
, he’s on Lupron and is currently failing Xtandi. What to ask for next steps? We are trying to go on a clinical trial at UCSF but things are moving slowly.
He’s done
Docetaxel
, he’s on Lupron and is currently failing Xtandi. What to ask for next steps? We are trying to go on a clinical trial at UCSF but things are moving slowly.
Blair77
in
Advanced Prostate Cancer
5 years ago
Clinical Implications of New Data on Apalutamide + ADT in Castrate-Sensitive Prostate Cancer
So, in my view,
docetaxel
is obviously not a contender here because there's no enthusiasm for continuing chemotherapy in our patients anywhere, regardless of the setting. So, when you have such a...we have such strong results coming from an oral pill, the decision making is pretty simple.
So, in my view,
docetaxel
is obviously not a contender here because there's no enthusiasm for continuing chemotherapy in our patients anywhere, regardless of the setting. So, when you have such a...we have such strong results coming from an oral pill, the decision making is pretty simple.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Metformin: after so many positive articles: ASCO no help with docetaxel for mCRPCa
https://www.physiciansweekly.com/asco-metformin-no-help-in…/
https://www.physiciansweekly.com/asco-metformin-no-help-in…/
Hidden
in
Advanced Prostate Cancer
5 years ago
Rising PSA after RP Hormone and Chemo
Hi All I am 65 years old, Brachytherapy Sept 2014 Gleason 3+4 PSA 8.5, July 2017 Salvage RP Gleason 4+5 PSA 9.0 positive 13/22 lymph nodes and seminal vesicles, LHRH hormone therapy Sept 2017,
Docetaxel
6/3 March 2018. PSA post chemo 0.2 then 0.5 Dec 2018 0.9 Jan 2019, 2.5 April 2019.
Hi All I am 65 years old, Brachytherapy Sept 2014 Gleason 3+4 PSA 8.5, July 2017 Salvage RP Gleason 4+5 PSA 9.0 positive 13/22 lymph nodes and seminal vesicles, LHRH hormone therapy Sept 2017,
Docetaxel
6/3 March 2018. PSA post chemo 0.2 then 0.5 Dec 2018 0.9 Jan 2019, 2.5 April 2019.
Ian54
in
Advanced Prostate Cancer
5 years ago
Side effects of docetaxel
I recently had my 4th chemo, my 1st
docetaxel
, on Wednesday. I am really struggling with joint pain, I know they said it might be a side effects but I’m in agony..... anyone else had this?
I recently had my 4th chemo, my 1st
docetaxel
, on Wednesday. I am really struggling with joint pain, I know they said it might be a side effects but I’m in agony..... anyone else had this?
TrishLamb
in
My Breast Cancer Community
5 years ago
Should be wait?
If his psa does not go down, he will start
docetaxel
infusions. Is it good to wait two months?
If his psa does not go down, he will start
docetaxel
infusions. Is it good to wait two months?
Mamabakes994
in
Advanced Prostate Cancer
5 years ago
Chemo and Liver damage
It's been 3 weeks now since I completed 6th
Docetaxel
, I've had some nerve tremors in hands and feet, the feet have totally cleared up and the hands are improving daily but my right side below my Ribs I feeling continuous twitching/pulsing which I assume is either my Liver or maybe hepatic artery or
It's been 3 weeks now since I completed 6th
Docetaxel
, I've had some nerve tremors in hands and feet, the feet have totally cleared up and the hands are improving daily but my right side below my Ribs I feeling continuous twitching/pulsing which I assume is either my Liver or maybe hepatic artery or
Zetabow
in
Advanced Prostate Cancer
5 years ago
What a bunch of..........
Just finished my first session of
Docetaxel
, feeling pretty good, but as usual, I turned to this board and folks like tall_allen et all, continuously posting, spreading their knowledge and inspiration. All I want to say is thank you, from the bottom of my heart, for your efforts.
Just finished my first session of
Docetaxel
, feeling pretty good, but as usual, I turned to this board and folks like tall_allen et all, continuously posting, spreading their knowledge and inspiration. All I want to say is thank you, from the bottom of my heart, for your efforts.
WINGER19
in
Advanced Prostate Cancer
5 years ago
RO said 6-12 months
He is supposed to start chemo with
docetaxel
soon. Currently he is only on lupron as everything else was stopped. I was wondering what options are available after chemo fails? He already has been on lupron, casodex, zytiga and xtandi. I see that a lot of people are doing trials.
He is supposed to start chemo with
docetaxel
soon. Currently he is only on lupron as everything else was stopped. I was wondering what options are available after chemo fails? He already has been on lupron, casodex, zytiga and xtandi. I see that a lot of people are doing trials.
dunde8889
in
Advanced Prostate Cancer
5 years ago
Docetaxel - day one
Today was my first day of
Docetaxel
. 17 months after being diagnosed apc. Gleason 9, PSA 55. First treatment was abiraterone, second was an immunotherapy trial, third was radiotherapy to the Prostate. Today I had a baseline CT scan, PSA currently 50.
Today was my first day of
Docetaxel
. 17 months after being diagnosed apc. Gleason 9, PSA 55. First treatment was abiraterone, second was an immunotherapy trial, third was radiotherapy to the Prostate. Today I had a baseline CT scan, PSA currently 50.
easeytiger
in
Advanced Prostate Cancer
5 years ago
Actinium 225 combined with Zytiga
After
Docetaxel
and Jevtana failed last year, hubby was given Zytiga with Prednisone in December 2018. After researching trials, we had the option to go to USA for Lu-177 or stay in South Africa. We were immediately accepted onto the ACtinium trial here.
After
Docetaxel
and Jevtana failed last year, hubby was given Zytiga with Prednisone in December 2018. After researching trials, we had the option to go to USA for Lu-177 or stay in South Africa. We were immediately accepted onto the ACtinium trial here.
Ldb01
in
Advanced Prostate Cancer
5 years ago
Smoking & ADT.
KEYWORDS: cigarettes;
docetaxel
; enzalutamide; prostate cancer; smoking PMID: 31077419 DOI: 10.1002/pros.23828
KEYWORDS: cigarettes;
docetaxel
; enzalutamide; prostate cancer; smoking PMID: 31077419 DOI: 10.1002/pros.23828
pjoshea13
in
Advanced Prostate Cancer
5 years ago
rising PSA on cabazitaxel !
He has had doxitaxel, xtandi, zytiga, Radium 223 ,
docetaxel
( second time) and cabazitaxel. His PSA continues to increase and today after his second cabazitaxel it remains at 95. We are so concerned since there has not been any treatment that lowered his PSA.
He has had doxitaxel, xtandi, zytiga, Radium 223 ,
docetaxel
( second time) and cabazitaxel. His PSA continues to increase and today after his second cabazitaxel it remains at 95. We are so concerned since there has not been any treatment that lowered his PSA.
joann48
in
Advanced Prostate Cancer
5 years ago
1 year on Zytiga
He was originally diagnosed with a G7 (4+3) Adenocarcinoma back in April 2017 and had both RP (failed but I think still helped him greatly) and a lighter version of
Docetaxel
chemo before starting Zytiga. He never had bone mets, always lymph nodes. Best wishes to all the other fighters!
He was originally diagnosed with a G7 (4+3) Adenocarcinoma back in April 2017 and had both RP (failed but I think still helped him greatly) and a lighter version of
Docetaxel
chemo before starting Zytiga. He never had bone mets, always lymph nodes. Best wishes to all the other fighters!
Dalph87
in
Advanced Prostate Cancer
5 years ago
about radiation
my mother had a mastactomy of right breast. tumar size-1.8*1.5*1.2 cm 3 of 17 lymph nodes show metastasis with size of largest deposit being 1.3*0.7 cm pathological stage-pT1c N1a er-98% pr-95% her-2 negative ki67-20% cancer is localised only she completed 3 cycles of ac and 2 cycles of
docetaxel
i want
my mother had a mastactomy of right breast. tumar size-1.8*1.5*1.2 cm 3 of 17 lymph nodes show metastasis with size of largest deposit being 1.3*0.7 cm pathological stage-pT1c N1a er-98% pr-95% her-2 negative ki67-20% cancer is localised only she completed 3 cycles of ac and 2 cycles of
docetaxel
i want
vikramgujjar
in
Breast Cancer India
5 years ago
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