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Docetaxel
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What next option available if CDK4/6 get failed
Sumeet Shah one of my relative diagnosed with oligometastatic left breast cancer in 2015 treated with chemo (4 Cycle 5FEC and 1 Cycle of
Docetaxel
) than surgery (lumpectomy) again 2 cycle of 5FEC chemo 2016 march NED put on tamoxifen 20 mg regular check up and in 2021 it relapsed in operated breast
Sumeet Shah one of my relative diagnosed with oligometastatic left breast cancer in 2015 treated with chemo (4 Cycle 5FEC and 1 Cycle of
Docetaxel
) than surgery (lumpectomy) again 2 cycle of 5FEC chemo 2016 march NED put on tamoxifen 20 mg regular check up and in 2021 it relapsed in operated breast
Deepak1965
in
Breast Cancer India
1 year ago
PSA is increasing after 11 cycle of Docetaxel, what should we do now ?
My father has done around 11 cycle of
Docetaxel
, 5 of them was combined with Cisplatin. First 3 cycles of
Docetaxel
alone took his PSA from 7 ng/mL down to 3.680. between cycle 4 to the end of cycle 7 his PSA increased to reach 8.03.
My father has done around 11 cycle of
Docetaxel
, 5 of them was combined with Cisplatin. First 3 cycles of
Docetaxel
alone took his PSA from 7 ng/mL down to 3.680. between cycle 4 to the end of cycle 7 his PSA increased to reach 8.03.
mgaa
in
Advanced Prostate Cancer
1 year ago
Need help finding studies
And then the doc’s post-visit notes recommended Zytiga or to consider treatment with
Docetaxel
, or a bunch of other meds… all the stuff we had asked about but he had said wasn’t appropriate when we were in the office with him. (Argh.)
And then the doc’s post-visit notes recommended Zytiga or to consider treatment with
Docetaxel
, or a bunch of other meds… all the stuff we had asked about but he had said wasn’t appropriate when we were in the office with him. (Argh.)
Tigger2022
in
Advanced Prostate Cancer
2 years ago
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not sure my Onco (or I)understood the Denmeade BAT paper.
Onco decided to delay Xtandi and go to
Docetaxel
to bring down PSA I had 6
Docetaxel
treatments. The last two were accompanied by Carboplatin and 40mg and 80mg of Xtandi respectively. This lowered PSA to 6. That was three months ago.
Onco decided to delay Xtandi and go to
Docetaxel
to bring down PSA I had 6
Docetaxel
treatments. The last two were accompanied by Carboplatin and 40mg and 80mg of Xtandi respectively. This lowered PSA to 6. That was three months ago.
Frigataflyer
in
Advanced Prostate Cancer
2 years ago
Sequence of treatments
Given my husband's post Enzalutamide
Docetaxel
treatment and the lack of a great response (so far), I had a look around for sequencing to see if
Docetaxel
might have been more effective before giving Enzalutamide.
Given my husband's post Enzalutamide
Docetaxel
treatment and the lack of a great response (so far), I had a look around for sequencing to see if
Docetaxel
might have been more effective before giving Enzalutamide.
spw1
in
Advanced Prostate Cancer
2 years ago
Pluvicto / Locametz in the Rocky Mountains yet?
Chemo with
Docetaxel
since Aug 2021, possibly starting to fail. Wanting the new Locametz / Pluvicto treatment before starting Cazabitaxel, but availability in the SLC / DEN area non-existant yet. Huntsman Cancer institute hopes to have it sometime in this fall, but no date given.
Chemo with
Docetaxel
since Aug 2021, possibly starting to fail. Wanting the new Locametz / Pluvicto treatment before starting Cazabitaxel, but availability in the SLC / DEN area non-existant yet. Huntsman Cancer institute hopes to have it sometime in this fall, but no date given.
foamhand
in
Advanced Prostate Cancer
2 years ago
Docetaxel again
He's going to start
docetaxel
, again, after having already done it in 2020. Has anyone here taken
docetaxel
more than once? Thanks.
He's going to start
docetaxel
, again, after having already done it in 2020. Has anyone here taken
docetaxel
more than once? Thanks.
JNunes
in
Advanced Prostate Cancer
2 years ago
What next?
After 4
Docetaxel
and 2 Cabazitaxel infusions, PSA went up from 99 in mid June to 821(676) last measured. On Monday night this week, my husband could not walk to go to the bathroom and was in immense pain in his left hip and leg.
After 4
Docetaxel
and 2 Cabazitaxel infusions, PSA went up from 99 in mid June to 821(676) last measured. On Monday night this week, my husband could not walk to go to the bathroom and was in immense pain in his left hip and leg.
spw1
in
Advanced Prostate Cancer
2 years ago
Is Pluvicto worth pursuing?
Dropped Xtandi and completed 6
docetaxel
sessions ending August 2022. Recent PSMA PET scan showed most lesions decreased in size/intensity with two sites (rib and hip) showing further progression.
Dropped Xtandi and completed 6
docetaxel
sessions ending August 2022. Recent PSMA PET scan showed most lesions decreased in size/intensity with two sites (rib and hip) showing further progression.
Battle_on
in
Advanced Prostate Cancer
2 years ago
define "metastatic"
(https://pubmed.ncbi.nlm.nih.gov/35371297) Wherein this statement is found " survival of metastatic HSPC can be improved with the addition to ADT of any one of
docetaxel
, abiraterone, acetate, prednisone combination, apalutamide, or darolutamide in combination with
docetaxel
".
(https://pubmed.ncbi.nlm.nih.gov/35371297) Wherein this statement is found " survival of metastatic HSPC can be improved with the addition to ADT of any one of
docetaxel
, abiraterone, acetate, prednisone combination, apalutamide, or darolutamide in combination with
docetaxel
".
runtrails
in
Advanced Prostate Cancer
2 years ago
Can eat a grassfed beef liver while in the process of Docetaxel chemo?
Started
Docetaxel
chemo last July 12/22 and 2nd time is in progress. His blood works is relatively low but within the limit. Can he eat the liver? Thank you.
Started
Docetaxel
chemo last July 12/22 and 2nd time is in progress. His blood works is relatively low but within the limit. Can he eat the liver? Thank you.
11redtomato_41
in
Advanced Prostate Cancer
2 years ago
Guardant Liquid Biopsy - when is best to do this?
On Lupron and 1/2 way thru 6
docetaxel
chemo treatments. Had genomic testing of biopsy sample which showed MMR deficient and MSI high. MO suggested doing liquid biopsy, though unclear on timing.
On Lupron and 1/2 way thru 6
docetaxel
chemo treatments. Had genomic testing of biopsy sample which showed MMR deficient and MSI high. MO suggested doing liquid biopsy, though unclear on timing.
rsgdmd
in
Advanced Prostate Cancer
2 years ago
No benefit of adding docetaxel to ADT+RT in treating localized high-risk or pelvic lymph node only (N1) newly-diagnosed patients
I updated this with the most recent STAMPEDE trial of adding
docetaxel
to ADT in what they call "high-risk" patients. https://www.prostatecancer.news/2016/08/
docetaxel
-with-primary-radiation.html
I updated this with the most recent STAMPEDE trial of adding
docetaxel
to ADT in what they call "high-risk" patients. https://www.prostatecancer.news/2016/08/
docetaxel
-with-primary-radiation.html
Tall_Allen
in
Prostate Cancer Network
2 years ago
No benefit of adding docetaxel to ADT+RT in treating localized high-risk or pelvic lymph node only (N1) newly-diagnosed patients
I updated this with the most recent STAMPEDE trial of adding
docetaxel
to ADT in what they call "high-risk" patients. https://www.prostatecancer.news/2016/08/
docetaxel
-with-primary-radiation.html
I updated this with the most recent STAMPEDE trial of adding
docetaxel
to ADT in what they call "high-risk" patients. https://www.prostatecancer.news/2016/08/
docetaxel
-with-primary-radiation.html
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Triplet Regimen vs Clinical Trial (Pluvicto)
The other treatment options is a triplet regimen, which will include the Lupron + anti-androgen + chemotherapy (
docetaxel
). I am 64 and otherwise in good physical shape. I would like to treat this as aggressively as we can, but I’m not sure what is the right choice in this case.
The other treatment options is a triplet regimen, which will include the Lupron + anti-androgen + chemotherapy (
docetaxel
). I am 64 and otherwise in good physical shape. I would like to treat this as aggressively as we can, but I’m not sure what is the right choice in this case.
Bruce98
in
Advanced Prostate Cancer
1 year ago
FDA Approves Darolutamide Plus Docetaxel for Metastatic Hormone-Sensitive Prostate Cancer
https://www.onclive.com/view/fda-and-ema-approval-sought-for-darolutamide-plus-
docetaxel
-in-metastatic-hormone-sensitive-prostate-cancer More info: https://www.urotoday.com/conference-highlights/asco-gu-2022/asco-gu-2022-prostate-cancer/135403-asco-gu-2022-overall-survival-with-darolutamide-versus-placebo-in-combination-with-androgen-deprivation-therapy-and-
docetaxel
-for-metastatic-hormone-sensitive-prostate-cancer-in-the-phase
https://www.onclive.com/view/fda-and-ema-approval-sought-for-darolutamide-plus-
docetaxel
-in-metastatic-hormone-sensitive-prostate-cancer More info: https://www.urotoday.com/conference-highlights/asco-gu-2022/asco-gu-2022-prostate-cancer/135403-asco-gu-2022-overall-survival-with-darolutamide-versus-placebo-in-combination-with-androgen-deprivation-therapy-and-
docetaxel
-for-metastatic-hormone-sensitive-prostate-cancer-in-the-phase
tango65
in
Advanced Prostate Cancer
2 years ago
Rezvilutamide: new anti-androgen is better than Casodex added to ADT for newly diagnosed high-met HSPC. But is field too crowded?
With Zytiga (abiraterone), Xtandi (enzalutamide), and Erleada (apalutamide) and
docetaxel
already approved for this purpose, I don't know whether Jiangsu Hengrui will be able to make significant inroads into the market, unless they are able to compete on price.
With Zytiga (abiraterone), Xtandi (enzalutamide), and Erleada (apalutamide) and
docetaxel
already approved for this purpose, I don't know whether Jiangsu Hengrui will be able to make significant inroads into the market, unless they are able to compete on price.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Oleic acid(OA), increases proliferation of highly malignant PC3 & DU145 PCa cells.Docetaxel cytotoxic action is significantly reduced by OA.
Furthermore,
docetaxel
cytotoxic action, the first-line chemotherapeutic agent for the treatment of androgen-independent PCa, was significantly reduced in the presence of OA, when measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, suggesting that this FFA plays also
Furthermore,
docetaxel
cytotoxic action, the first-line chemotherapeutic agent for the treatment of androgen-independent PCa, was significantly reduced in the presence of OA, when measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay, suggesting that this FFA plays also
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Tailbone Spasms from Neulasta
After my second dose of chemo (
Docetaxel
), I ended up in the ER with a fever. My white blood cell count was 1.2 K/CMM and Neutrophils were 0 K/CMM (!). Anyway, I was approved for Neulasta and had the injection 24 hours after my 3rd chemo infusion.
After my second dose of chemo (
Docetaxel
), I ended up in the ER with a fever. My white blood cell count was 1.2 K/CMM and Neutrophils were 0 K/CMM (!). Anyway, I was approved for Neulasta and had the injection 24 hours after my 3rd chemo infusion.
carguy
in
Advanced Prostate Cancer
1 year ago
looking for treatment advice
He completed 6
docetaxel
treatments in April. PSA has slowly gone from almost 7000 to 4 since last diagnosis last September. So far it is still slowly dropping each month but no where near undetectable. He has done well on all treatments thus far and feels good except for the fatigue.
He completed 6
docetaxel
treatments in April. PSA has slowly gone from almost 7000 to 4 since last diagnosis last September. So far it is still slowly dropping each month but no where near undetectable. He has done well on all treatments thus far and feels good except for the fatigue.
Bspouse
in
Advanced Prostate Cancer
2 years ago
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