Docetaxel vs cabazitaxel

[Mrtroxely]

hi all, i read artical on neuropathy.

I seem to have few numb fingertips, right hand ends of middle fingers,

this was before any treatment and came about during getting diagnosed when i started urinating blood.

my fear is its cancer in bones pushing on a nerve, or damage to nervess in fingers??? But this is just my own fear based self diagnosis???

I read that cabazcabazitaxel has less side effects and less chance of neuropathy but can be offered to people who already have signs of neuropathy???

Does any one have any thoughts on this,

Thank you all

[tango65]

I have a peripheral neuropathy caused by a vaccine treatment I had. Peripheral neuropathies are not localized to only one hand. You need to consult with an internal medicine doctor to determine why you have a problem with the right middle fingers.

[Hidden]

I  have debated whether to offer an opinion….. from my eceoeriences experiences with nine infusions of Taxotere alternated with Adrimyacin over a six month period. Adrimyacin is often called the Red Devil and given over a 24 hour pump. Before every infusion. Blood work, check of nails, throat, and any neuropathy. Major side effects of any are monitored. If they are too severe, then the chemo agent is stopped. Most side effects are overcomed with other medical treatment. My friend you are obsessing too much on the possibility of side effects. Take the chemo and deal with the results.  You won’t know until you have the infusion. I had zero side effects. Others are not so lucky. Scope of disease, body strength and tumor burden are key. Stay positive and kill the little bastards. The alternative is not very good. Gourd Dancer

[Mrtroxely in reply to Hidden]

Yo dude, read your posts and profile, looks like they found the cure for you.

Not sure not all getting same concoction.....

But theres a theme, swapping treatments, extreme things, including diet?(religion???)

[Mrtroxely in reply to Hidden]

I have friend I meet up with was 50 at dx with pca

Mets in pelvis, hip, ribs, was offered trial stampede, didnt take part.

Has had hormone injections, no chemo, no radio therapy, changed diet and looks in good shape today over 10 years later, hes on gleason score 7 similar to you?

Its good to hear evidence of others experience, so im up for killing cancer cells.

[EdBacon]

Cabazitaxel has a significantly lower incidence of neuropathy as compared to Docetaxel. Overall, the side effects are also easier for many, including me. I'm on my 3rd cycle now. It's been quite a bit easier than Docetaxel. Best to ask your doctor if it's possible for you to try.

[lokibear0803]

Peripheral neuropathy can have many causes and various presentations, and in many cases can be transient (I’m speaking from my own experience). In my case, I’ve recently had both carpal tunnel issues (which I addressed with corticosteroid injections) and, more recently, painful nerve ending shocks (I call them zingers) and numbness in my right leg/foot. I’m addressing right-side issues with gapapentin, which is known to be effective for this kind of thing.

The root cause of my right-side issues is likely stenosis in L5-S1, but I’ll deal with that directly only if-when I have to. I hope never - gabapentin is saving me so far (for a month by now, after several weeks of intensely painful zingers).

I’d recommend visiting a physiatrist (or hand specialist, in your case) as a starting point. From there, you may need neurologist involvement; it depends what is diagnosis. And yes, it could be from the chemo — but at the end of the day, it’s about nerve endings. And, like I say, gabapentin (or pregabalin) can be a first-cut non-invasive remedy for nervous system pathology, and it may work for an extended time if not indefinitely.

My next level of remedy would involve corticosteroid in L5-S1, and if that’s not effective I’d have to consider foraminotomy, etc surgical.

Before I started gabapentin, I would address the right-foot zingers and numbness by overwhelming the nerve endings — using a small hard rubber roller with spikes, and leaning into it with bottom of foot. The theory is to swamp the nerve ending with over-stimulus so that they stop sending pain signals. Surprisingly, it worked.

Some have tried topical capsaicin, which follows the same theory: the heat from the topical overwhelms the nerves. Didn’t work for me, in fact it put my foot into miserable burning pain for several hours.

Again, all of above is from my own experience and learning curve. And, again, I would start with a physiatrist. Best of luck to you!