Local injection of docetaxel shows promise for bladder cancer. Maybe it could be used for PCa where systematic therapy was not tolerated.

[Graham49]

Kates M, Mansour AM, Lamm DL, et al. Phase 1/2 trial results of a large surface area microparticle docetaxel for the treatment of high-risk nonmuscle-invasive bladder cancer. J Urol. 2022 Oct;208(4):821-829. doi:10.1097/JU.0000000000002778

[cesces]

Interesting idea.

But only to supplement systemic therapy

By the time you get to docetaxel, you really don't know where the cancer is, even after a scan that will only find larger tumors.