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Next step options after lupron/zytiga failed
I have been on monthly Lupron for 7 years (starting in 2014) after the spread of prostate cancer to my bones following a prostatectomy in 2014. Lupron alone was very effective until December 2021. I then added Zytiga/Prednisone which had worked well. But current (June 2024) scans show substantial disease
I have been on monthly Lupron for 7 years (starting in 2014) after the spread of prostate cancer to my bones following a prostatectomy in 2014. Lupron alone was very effective until December 2021. I then added Zytiga/Prednisone which had worked well. But current (June 2024) scans show substantial disease
sleepless-in-seattle
in
Advanced Prostate Cancer
3 months ago
Targeted Biopsy
I live on the east coast of North Carolina. I’m looking for top choices of medical centers that conducts MRI targeted biopsies. I’ve been on active surveillance for 10 years but last three PSA tests have been rising. I’m currently being treated at Duke Medical but want to ensure best care for targeted
I live on the east coast of North Carolina. I’m looking for top choices of medical centers that conducts MRI targeted biopsies. I’ve been on active surveillance for 10 years but last three PSA tests have been rising. I’m currently being treated at Duke Medical but want to ensure best care for targeted
Scvol
in
Prostate Cancer Network
3 months ago
Can medication elevate the PSA?
My PSA at time of the cancer diagnosis was 5.56. Being in the hospital right now with several meds surging through me, the PSA is at 348.00. Is this a normal reaction?
My PSA at time of the cancer diagnosis was 5.56. Being in the hospital right now with several meds surging through me, the PSA is at 348.00. Is this a normal reaction?
PARKER3237
in
Advanced Prostate Cancer
3 months ago
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Estrogen for Bone Health in PCa patient.
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
binati
in
Advanced Prostate Cancer
3 months ago
Brachytherapy boost HDR vs LDR +/- ADT
A bit of my background: 50 years old, Gleason score of 4+3, a PSA of 11, decipher is low, and possible extracapsular extension. 1) I know what LDR and HDR do, but what are the differences in terms of their long-term side effects? 2) Should I include ADT for a better outcome and what percentage improvement
A bit of my background: 50 years old, Gleason score of 4+3, a PSA of 11, decipher is low, and possible extracapsular extension. 1) I know what LDR and HDR do, but what are the differences in terms of their long-term side effects? 2) Should I include ADT for a better outcome and what percentage improvement
Infamous9597
in
Advanced Prostate Cancer
3 months ago
1 Yr on pBAT Results
Hi fellow warriors. After one year of Orgovyx and Darolutamide and still hormone sensitive i decided to change to a testosterone propionate BAT protocol (Russ' Protocol) Here is a graph of my PSA numbers. all the peaks were taken after or during high T cycle. The Highest Peak is 2.46 and lowest 0.03
Hi fellow warriors. After one year of Orgovyx and Darolutamide and still hormone sensitive i decided to change to a testosterone propionate BAT protocol (Russ' Protocol) Here is a graph of my PSA numbers. all the peaks were taken after or during high T cycle. The Highest Peak is 2.46 and lowest 0.03
KocoPr
in
Fight Prostate Cancer
3 months ago
Bone scan/CT sensitivity?
My husband has only ever had regular nuclear bone scan and CT. PSA is now rising over 6 months from .45 to.9. At what PSA level would repeat scans be likely to image progression? I am aware of PSMA and this might come down the line but currently from what I read from TA and others is that we need comparable
My husband has only ever had regular nuclear bone scan and CT. PSA is now rising over 6 months from .45 to.9. At what PSA level would repeat scans be likely to image progression? I am aware of PSMA and this might come down the line but currently from what I read from TA and others is that we need comparable
Proflac
in
Advanced Prostate Cancer
3 months ago
Radiation Confusion- please help clarify
Referred to and met with radiation oncologist because my PC is active again after almost 3 years. This will be my first experience with radiation. It was explained and I thought I understood but am now completely confused - scans (PSMA, MRI, CT and bone scan) showed activity in prostate, SV, and one
Referred to and met with radiation oncologist because my PC is active again after almost 3 years. This will be my first experience with radiation. It was explained and I thought I understood but am now completely confused - scans (PSMA, MRI, CT and bone scan) showed activity in prostate, SV, and one
MPCSUX
in
Advanced Prostate Cancer
3 months ago
Enzalutamide Plus 5-Alpha Reductase Inhibitors for Castrate-Sensitive Prostate Cancer
Phase II trial exploring the combination of enzalutamide with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer. Driven by observations from geriatric oncology, the study seeks alternatives to androgen deprivation therapy (ADT) for older, frail men who struggle with its side
Phase II trial exploring the combination of enzalutamide with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer. Driven by observations from geriatric oncology, the study seeks alternatives to androgen deprivation therapy (ADT) for older, frail men who struggle with its side
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Signifficant PSA LEVELS
I'm an 81 year old man who has had an enlarged prostate for several months. PSA tests levels 9.1 and 8.1 (several months apart). My Father died of prostate cancer, which had spread to other parts of his body. Follwing a Digital Anal test, my prostate was reported as "smoothly enlarged and sulcus palpable
I'm an 81 year old man who has had an enlarged prostate for several months. PSA tests levels 9.1 and 8.1 (several months apart). My Father died of prostate cancer, which had spread to other parts of his body. Follwing a Digital Anal test, my prostate was reported as "smoothly enlarged and sulcus palpable
apttony
in
Prostate Cancer Network
3 months ago
Uro visit post bone scan
Hello everyone, having one foot into the club, After PSA 46 and MRI showing contained growth but not 100% sure, today bone scan is confirmed as negative.Uro still suspects APC, whether contained or not, wants a biopsy on Monday 17th. I started a strict vegan diet and extra gym days plus other diet interventions
Hello everyone, having one foot into the club, After PSA 46 and MRI showing contained growth but not 100% sure, today bone scan is confirmed as negative.Uro still suspects APC, whether contained or not, wants a biopsy on Monday 17th. I started a strict vegan diet and extra gym days plus other diet interventions
Hotoneii
in
Advanced Prostate Cancer
3 months ago
Does PSA drop after starting ADT tell us anything?
My husband started Firmagon shots a month ago. Before starting his PSA was 5.9. It was tested a few days ago and it’s 1.4 now. Does this tell us anything of any significance? Thanks!
My husband started Firmagon shots a month ago. Before starting his PSA was 5.9. It was tested a few days ago and it’s 1.4 now. Does this tell us anything of any significance? Thanks!
EvFC
in
Advanced Prostate Cancer
3 months ago
Testosterone Replacement Therapy ????
Hello Brothers ! Wishing everyone a great summer ! Or winter …. If you are on the other end of the globe ! I am now almost over 5.5 years since my last Lupron injection and have had undetectable PSA for almost 7 years. My testosterone recovered to greater than 200 in late 2019. For 2.5 years testosterone
Hello Brothers ! Wishing everyone a great summer ! Or winter …. If you are on the other end of the globe ! I am now almost over 5.5 years since my last Lupron injection and have had undetectable PSA for almost 7 years. My testosterone recovered to greater than 200 in late 2019. For 2.5 years testosterone
G9doingfine
in
Advanced Prostate Cancer
3 months ago
Xtandi/Orgovyx Combo & Heart Rate
My MO added Xtandi to my Orgovyx regimen in late January. I am oligometastatic - one lymph node - and PSA is 0.07 with testosterone at 9.63. I am not castrate resistant. I was wondering if anyone else has experienced slowing heart rate (bradycardia) on this combo. (I also take Myrbetriq which may
My MO added Xtandi to my Orgovyx regimen in late January. I am oligometastatic - one lymph node - and PSA is 0.07 with testosterone at 9.63. I am not castrate resistant. I was wondering if anyone else has experienced slowing heart rate (bradycardia) on this combo. (I also take Myrbetriq which may
Explorer08
in
Advanced Prostate Cancer
3 months ago
Docetaxal chemotherapy
I have had prostate cancer since 2017. First I had radiation and then Lupron for three years. When my PSA started to rise I took abiraterone and Lupron for 3 more years and was undetectable. It started to rise again to 1.78. Then I was put on Xtandi but after a week I developed a full body rash. When
I have had prostate cancer since 2017. First I had radiation and then Lupron for three years. When my PSA started to rise I took abiraterone and Lupron for 3 more years and was undetectable. It started to rise again to 1.78. Then I was put on Xtandi but after a week I developed a full body rash. When
Gern
in
Advanced Prostate Cancer
3 months ago
Terrible sleep issues
So now I’m 10+ weeks into treatment consisting of Lupron+Abiraterrone and have completed 5 of 20 radiation sessions. In many ways things seem to be going very well. My PSA numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot
So now I’m 10+ weeks into treatment consisting of Lupron+Abiraterrone and have completed 5 of 20 radiation sessions. In many ways things seem to be going very well. My PSA numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot
Willie51
in
Prostate Cancer And Gay Men
3 months ago
Please advice
My latest PSA on 6/11/24 was 1.06 up from 0.65 on 4/2/24. I have a meeting with my MO on 4/26 to discuss the next step. I was taking Opdivo immunotherapy from 2/2023 to 2/2024 for bladder cancer. so far my bladder cancer is in check so now I can focus on my PCA. Should I get a PSMA pet? is it time to
My latest PSA on 6/11/24 was 1.06 up from 0.65 on 4/2/24. I have a meeting with my MO on 4/26 to discuss the next step. I was taking Opdivo immunotherapy from 2/2023 to 2/2024 for bladder cancer. so far my bladder cancer is in check so now I can focus on my PCA. Should I get a PSMA pet? is it time to
old64horn
in
Advanced Prostate Cancer
3 months ago
Recent dropping of guideline "Post from your own experience".
I find this forum useful and informative, especially when members share from their personal experiences. IMO the dropping of the referenced guideline is not an enhancement to this forum. Currently, I am one of the participants in discussions about surgery and ultrasensitive PSA testing. I have considerable
I find this forum useful and informative, especially when members share from their personal experiences. IMO the dropping of the referenced guideline is not an enhancement to this forum. Currently, I am one of the participants in discussions about surgery and ultrasensitive PSA testing. I have considerable
NanoMRI
in
Advanced Prostate Cancer
3 months ago
PSA Rising
RP 2 years and four months ago. PSA went from <.02 to currently .27, Testosterone at about 600+ Since surgery, there has been no intervention. It looks like it is time to take action. Does the group have any suggestions?
RP 2 years and four months ago. PSA went from <.02 to currently .27, Testosterone at about 600+ Since surgery, there has been no intervention. It looks like it is time to take action. Does the group have any suggestions?
Gulfrider
in
Prostate Cancer Network
3 months ago
provenge before metastasis
Is there a current Cancer Center that is a leader in immunotherapy Would there be any benefit in taking provenge after treatment when your PSA is low?
Is there a current Cancer Center that is a leader in immunotherapy Would there be any benefit in taking provenge after treatment when your PSA is low?
Vortex12
in
Prostate Cancer Network
3 months ago
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