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BTK Degrader Shows Potential for Treating Refractory CLL and SLL
A novel Bruton's tyrosine kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor. NX-2127 a BTK degrader has a novel
A novel Bruton's tyrosine kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor. NX-2127 a BTK degrader has a novel
Jm954
Administrator
in
CLL Support
1 year ago
Agios and Alnylam sign agreement for siRNA candidate
« We are pleased to license this programme from Alnylam, the leading RNAi therapeutics company, with the goal of delivering a convenient, disease-modifying treatment option that addresses the underlying pathophysiology of PV and reduces or eliminates the need for phlebotomy. “We look forward to initiating
« We are pleased to license this programme from Alnylam, the leading RNAi therapeutics company, with the goal of delivering a convenient, disease-modifying treatment option that addresses the underlying pathophysiology of PV and reduces or eliminates the need for phlebotomy. “We look forward to initiating
Manouche
in
MPN Voice
9 months ago
tasquinimod in myelofibrosis (MF)
»The data showed that treatment with this drug results in normal blood counts, reduction of fibrosis in the bone marrow and normalization of spleen size in this mouse model. That suggests that tasquinimod can act as a disease modifying agent in MF » « The now planned study will investigate tasquinimod
»The data showed that treatment with this drug results in normal blood counts, reduction of fibrosis in the bone marrow and normalization of spleen size in this mouse model. That suggests that tasquinimod can act as a disease modifying agent in MF » « The now planned study will investigate tasquinimod
Manouche
in
MPN Voice
9 months ago
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Jakafi + Grapefruit
Just came across this warning on Drugs.com. I had never seen before. Have those of you on Jakafi (ruxolitinib) seen this warning?
ruxolitinib food Applies to: Jakafi (ruxolitinib)
Do not consume grapefruit or grapefruit juice during treatment with ruxolitinib unless directed otherwise by
Just came across this warning on Drugs.com. I had never seen before. Have those of you on Jakafi (ruxolitinib) seen this warning?
ruxolitinib food Applies to: Jakafi (ruxolitinib)
Do not consume grapefruit or grapefruit juice during treatment with ruxolitinib unless directed otherwise by
hunter5582
in
MPN Voice
9 months ago
CLL Webinar
Hi all Here is the link for today's CLL webinar. This educational webinar will give an overview of how CLL is treated today and the significance of ’hot topics’ and key treatment development advances published and discussed at 2022 international hematology conferences. What is new and what does this
Hi all Here is the link for today's CLL webinar. This educational webinar will give an overview of how CLL is treated today and the significance of ’hot topics’ and key treatment development advances published and discussed at 2022 international hematology conferences. What is new and what does this
Irishcll
in
CLL Support
1 year ago
Changing Medication
Hi I’m just looking for some advice on Targinact and just Oxycodone please. My neurologist wrote to my GP requesting that I be prescribed Targinact 10mg at night and 5mg mornings increasing if necessary by 5mg increments to maximum of 20mg twice a day, also changing the Venlafaxine I take to either
Hi I’m just looking for some advice on Targinact and just Oxycodone please. My neurologist wrote to my GP requesting that I be prescribed Targinact 10mg at night and 5mg mornings increasing if necessary by 5mg increments to maximum of 20mg twice a day, also changing the Venlafaxine I take to either
Felixstowe
in
Restless Legs Syndrome
18 days ago
B LARGE CELL DIFFUSE LYMPHOMA AFTER 5 YEAR OF POST KIDNEY TRANSPLANT
I got my kidney transplant in dec 2018 now In nov 2024 suffered from NON hodgkin lymphoma now only on tacrolimus 5mg daily .Any advice regarding this then plz
I got my kidney transplant in dec 2018 now In nov 2024 suffered from NON hodgkin lymphoma now only on tacrolimus 5mg daily .Any advice regarding this then plz
bal_123
in
Kidney Transplant Patient Support
1 month ago
My Ckd journey
Hi my name is Dineshwaran.i was diagnosed with kidney failure in year 2003 when I was 19.was on dialysis for two years and did transplant on 2005. Donated by my cousin.it was a perfect match until 2017 where my sugar level was very high. Was on all type of medication and insulin but didn't came down
Hi my name is Dineshwaran.i was diagnosed with kidney failure in year 2003 when I was 19.was on dialysis for two years and did transplant on 2005. Donated by my cousin.it was a perfect match until 2017 where my sugar level was very high. Was on all type of medication and insulin but didn't came down
Dineshwaran
in
Kidney Dialysis
2 months ago
looking for a neurologist
Can anyone recommend a neurologist knowledgeable in RLS in the Bristol/ Bath (England) area ? I currently have a neurologist whom I rate quite highly but who cannot prescribe opioids as they are not on the formulary of the hospital where she practises. She has however asked my GP to prescribe Oxycodone
Can anyone recommend a neurologist knowledgeable in RLS in the Bristol/ Bath (England) area ? I currently have a neurologist whom I rate quite highly but who cannot prescribe opioids as they are not on the formulary of the hospital where she practises. She has however asked my GP to prescribe Oxycodone
etchea33
in
Restless Legs Syndrome
2 months ago
PMR and brachial neuritis
It looks like I have developed a fairly rare condition called Parsonage-Turner syndrome (PTS), also called brachial neuritis. It started with terrible pain in the shoulder, so initially I thought it would appear in the other shoulder and be the beginning of a PMR relapse. But it is taking a different
It looks like I have developed a fairly rare condition called Parsonage-Turner syndrome (PTS), also called brachial neuritis. It started with terrible pain in the shoulder, so initially I thought it would appear in the other shoulder and be the beginning of a PMR relapse. But it is taking a different
dmart7
in
PMRGCAuk
2 months ago
Jak2/tet2 mutation
Hello this is Ben from VA! I was diagnosed with MPN last year and use Besremi every 2 weeks. I have jak2/tet2 mutations which makes me feel confused and scared since the majority of PVs only have jak2(or other so-called driver mutations). I read a lot online and it seems tet2 is not the worst thing
Hello this is Ben from VA! I was diagnosed with MPN last year and use Besremi every 2 weeks. I have jak2/tet2 mutations which makes me feel confused and scared since the majority of PVs only have jak2(or other so-called driver mutations). I read a lot online and it seems tet2 is not the worst thing
Ben2022
in
MPN Voice
9 months ago
Throat tightness
Hello has anyone had tightness in throat like pressure feeling? I can breathe and swallow ok but it's so annoying. I've been suffering severe fatigue and feeling like my body is full of led my GP continues to take blood and did mention I have hyperthyroidism before Christmas but didn't give me any
Hello has anyone had tightness in throat like pressure feeling? I can breathe and swallow ok but it's so annoying. I've been suffering severe fatigue and feeling like my body is full of led my GP continues to take blood and did mention I have hyperthyroidism before Christmas but didn't give me any
Joylene123
in
Thyroid UK
3 months ago
ACR (Microalbumin/Creatinine Ratio)
My Urine’s ACR result is 8.4 mg/mmol. HbA1C is 8.5. I am very worried. Kindly advise or provide insights.
My Urine’s ACR result is 8.4 mg/mmol. HbA1C is 8.5. I am very worried. Kindly advise or provide insights.
Limeandlemon
in
Diabetes India
3 months ago
Epipen - Serious Nut Allergy
EpiPen - Serious Nut Allergy Good afternoon, My daughter got tested today at Preston Hospital, she tested positive for all types of nuts and was told she has Serious Nut Allergy which is Life Threatening without the Use of an Injectable EpiPen. My daughter was given one today at Hospital. Her Question
EpiPen - Serious Nut Allergy Good afternoon, My daughter got tested today at Preston Hospital, she tested positive for all types of nuts and was told she has Serious Nut Allergy which is Life Threatening without the Use of an Injectable EpiPen. My daughter was given one today at Hospital. Her Question
Joseph260268
in
Lung Conditions Community Forum
10 months ago
Ruxolitinib
Hi all, I have PV and AB is high , around 81% , spleen size slightly increased but if I didn’t know I have PV I would think I am the healthiest person around as I have no symptoms. I was diagnosed end of 2018 but had it al least since 2015. I am considering taking a part in clinical trial for Ruxo and
Hi all, I have PV and AB is high , around 81% , spleen size slightly increased but if I didn’t know I have PV I would think I am the healthiest person around as I have no symptoms. I was diagnosed end of 2018 but had it al least since 2015. I am considering taking a part in clinical trial for Ruxo and
Ameliav
in
MPN Voice
10 months ago
Sugar Alcohols Ruined My Health: Learn from My Mistakes
Given the number of members who are intolerant to Teva levothyroxine, this video might be of some interest. Many suspect it is the mannitol content of Teva levothyroxine that lies behind the intolerance. After all, there were also many complaints around the world as Merck have slowly move from lactose
Given the number of members who are intolerant to Teva levothyroxine, this video might be of some interest. Many suspect it is the mannitol content of Teva levothyroxine that lies behind the intolerance. After all, there were also many complaints around the world as Merck have slowly move from lactose
helvella
Thyroid UK
in
Thyroid UK
3 months ago
Ruxalitinib and Peg interferon
AS previously mentioned my husband {He has PV and MPN} has for the past 6 years been on Ruxolitinib . He has now been advised that owing to quite a few skin cancers the last one being Squamous skin cancer with extensive scalp debridement. All in all in past 3 years he has had approx 7/8 basil cell
AS previously mentioned my husband {He has PV and MPN} has for the past 6 years been on Ruxolitinib . He has now been advised that owing to quite a few skin cancers the last one being Squamous skin cancer with extensive scalp debridement. All in all in past 3 years he has had approx 7/8 basil cell
waddles22
in
MPN Voice
10 months ago
Hi everyone and Happy New Year
my name is Jill and it’s been along while since I’ve posted anything. I was diagnosed in 1999. Aged 39. Despite being very unwell for months and being ‘fobbed ’ off by my Gp. By the time I was diagnosed I had Saddle Nose deformity. Like alot of you even as a nurse I was very scared and felt alone
my name is Jill and it’s been along while since I’ve posted anything. I was diagnosed in 1999. Aged 39. Despite being very unwell for months and being ‘fobbed ’ off by my Gp. By the time I was diagnosed I had Saddle Nose deformity. Like alot of you even as a nurse I was very scared and felt alone
Essex-jill
in
Vasculitis UK
4 months ago
Can anyone figure out my MRD
Can anyone figure out what my MRD ( CLL cells per 10,000) is from this report. Component Your Value Standard Range Interpretation Flow cytometric immunophenotyping performed on the peripheral blood shows a small, dim kappa restricted B-cell population (representing ~98% of B cells, 6% of total
Can anyone figure out what my MRD ( CLL cells per 10,000) is from this report. Component Your Value Standard Range Interpretation Flow cytometric immunophenotyping performed on the peripheral blood shows a small, dim kappa restricted B-cell population (representing ~98% of B cells, 6% of total
johnliston
in
CLL Support
1 year ago
A trial examining the effects of pausing BTKis to coincide with SARS-CoV-2 vaccination and its impact on immune responses in CLL patients
Trial registration number ISRCTN14197181 https://bmjopen.bmj.com/content/13/9/e077946 This study aims to determine in patients with
chronic
lymphocytic
leukaemia
(CLL) if a 3-week pause in Bruton tyrosine kinase inhibitor therapy (BTKi) starting 1 week before delivery of SARS-CoV-2 vaccine booster
Trial registration number ISRCTN14197181 https://bmjopen.bmj.com/content/13/9/e077946 This study aims to determine in patients with
chronic
lymphocytic
leukaemia
(CLL) if a 3-week pause in Bruton tyrosine kinase inhibitor therapy (BTKi) starting 1 week before delivery of SARS-CoV-2 vaccine booster
gardening-girl
in
CLL Support
7 months ago
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