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The CRP:Albumin ratio & CRPC Survival
PMID: 37435750 DOI: 10.4081/aiua.2023.11242 Abstract Objective: To assess the association of C reactive protein/Albumin ratio (CAR) with progression free survival (PFS) and overall survival (OS) in
castration
resistant metastatic prostate cancer (mCRPC) patients.
PMID: 37435750 DOI: 10.4081/aiua.2023.11242 Abstract Objective: To assess the association of C reactive protein/Albumin ratio (CAR) with progression free survival (PFS) and overall survival (OS) in
castration
resistant metastatic prostate cancer (mCRPC) patients.
pca2004
in
Fight Prostate Cancer
1 year ago
Has anyone returned to the first line of HT after second line failed?
I was thinking that doing ADT alternatively can stop
castration
resistence. If it works for all of us like going back and forth, then we can all prolong our lives a little bit more. Question 2: Is it true that Casadox feeds prostate cancer?
I was thinking that doing ADT alternatively can stop
castration
resistence. If it works for all of us like going back and forth, then we can all prolong our lives a little bit more. Question 2: Is it true that Casadox feeds prostate cancer?
tarzantass
in
Advanced Prostate Cancer
1 year ago
Casodex after castration resistance?
After being undetectable on mono HT (Zoladex) for 67 months my dad's PSA started climbing in December 2022. In March it was 0.05. His testosterone level also rose from 0.6 to 1.2. The doctor recommended to add Casodex. After a month, in April his PSA was 0.024 and testosterone was 0.9. I have two questions
After being undetectable on mono HT (Zoladex) for 67 months my dad's PSA started climbing in December 2022. In March it was 0.05. His testosterone level also rose from 0.6 to 1.2. The doctor recommended to add Casodex. After a month, in April his PSA was 0.024 and testosterone was 0.9. I have two questions
Nestorian
in
Advanced Prostate Cancer
1 year ago
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Pulmonary Complications Post Lutetium-177-PSMA-617 Therapy in Metastatic Castration-Resistant Prostate Cancer #Pluvicto
Source link : https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/150287-diffuse-pneumonitis-after-lutetium-177-psma-617-treatment-in-a-patient-with-metastatic-
castration
-resistant-prostate-cancer-beyond-the-abstract.html
Source link : https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/150287-diffuse-pneumonitis-after-lutetium-177-psma-617-treatment-in-a-patient-with-metastatic-
castration
-resistant-prostate-cancer-beyond-the-abstract.html
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
However, in the
castration
-resistant status, PCa cells remain highly dependent on the AR signaling axis, and proof of it is that many men with
castration
-resistant prostate cancer (CRPC) still respond to newer-generation AR signaling inhibitors (ARSis).
However, in the
castration
-resistant status, PCa cells remain highly dependent on the AR signaling axis, and proof of it is that many men with
castration
-resistant prostate cancer (CRPC) still respond to newer-generation AR signaling inhibitors (ARSis).
pca2004
in
Fight Prostate Cancer
1 year ago
NUV-1511 drug-drug conjugate (DDC) to enter the clinical stage: phase 1
Food and Drug Administration (FDA) labeling, human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer, metastatic
castration
-resistant prostate cancer (mCRPC), advanced pancreatic cancer, and platinum-resistant ovarian cancer (PROC).
Food and Drug Administration (FDA) labeling, human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer, metastatic
castration
-resistant prostate cancer (mCRPC), advanced pancreatic cancer, and platinum-resistant ovarian cancer (PROC).
Maxone73
in
Advanced Prostate Cancer
4 months ago
FDA approves a new IND application of 225Ac-J591 (Actinium)
under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer of the therapy, in a news release. 225Ac-J591 demonstrated safety and preliminary efficacy across all dose levels in predominantly 177Lu-naïve patients with metastatic
castration
-resistant
under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer of the therapy, in a news release. 225Ac-J591 demonstrated safety and preliminary efficacy across all dose levels in predominantly 177Lu-naïve patients with metastatic
castration
-resistant
Maxone73
in
Advanced Prostate Cancer
4 months ago
What’s after Lu-177 in Vancouver, BC?
He’s
castration
-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but sense then it’s been climbing slowly (~4.00 currently). What’s next? I’m his eldest daughter, 27, and I just can’t bear to see him in this position. I feel hopeless and devastated.
He’s
castration
-resistant and metastatic. PSA decreased considerably after the first Lu-177 infusion but sense then it’s been climbing slowly (~4.00 currently). What’s next? I’m his eldest daughter, 27, and I just can’t bear to see him in this position. I feel hopeless and devastated.
PHnerd
in
Advanced Prostate Cancer
7 months ago
Sacituzumab govitecan, an anti-Trop-2 antibody-drug conjugate, for treating cerebral metastasized castration-resistant prostate cancer.
Improved survival rates have been observed in
castration
-resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorable prognosis.
Improved survival rates have been observed in
castration
-resistant prostate cancer (CRPC) due to advancements in treatment options. However, individuals with brain metastases still have limited therapeutic options and an unfavorable prognosis.
God_Loves_Me
in
Advanced Prostate Cancer
5 days ago
New Mets, PSA 0.4
Is it becoming
Castration
-resistant prostate cancer? What should we expect to happen?
Is it becoming
Castration
-resistant prostate cancer? What should we expect to happen?
godhelpus
in
Advanced Prostate Cancer
5 months ago
Pluvicto and babies in house
My dad lives with us (including 3 month old) and is metastatic
castration
resistant. He has done 7 doses of docetaxel but last month his PSA increased again so I'm wondering and trying to prepare for next treatment options.Thank you in advance!
My dad lives with us (including 3 month old) and is metastatic
castration
resistant. He has done 7 doses of docetaxel but last month his PSA increased again so I'm wondering and trying to prepare for next treatment options.Thank you in advance!
HumongousPug
in
Advanced Prostate Cancer
1 year ago
Big company buys a clinical research company focused on Actinium 225 (and others) FPI-2265
markets/deals/astrazeneca-buy-fusion-pharma-2-billion-cash-2024-03-19/ Presentation at AACR Annual Meeting 2024 (9th of April): Title: Preliminary efficacy and safety results from the (TATCIST) trial: A PSMA-directed targeted alpha therapy with FPI-2265 (225Ac-PSMA-I&T) for the treatment of metastatic
castration
-resistant
markets/deals/astrazeneca-buy-fusion-pharma-2-billion-cash-2024-03-19/ Presentation at AACR Annual Meeting 2024 (9th of April): Title: Preliminary efficacy and safety results from the (TATCIST) trial: A PSMA-directed targeted alpha therapy with FPI-2265 (225Ac-PSMA-I&T) for the treatment of metastatic
castration
-resistant
Maxone73
in
Advanced Prostate Cancer
4 months ago
FDA Grants Fast Track Designation for 177Lu-PNT2002 for the Treatment of Metastatic Castration Resistant Prostate Cancer
https://www.globenewswire.com/news-release/2023/04/24/2652585/0/en/Lantheus-and-POINT-Biopharma-Announce-FDA-Grants-Fast-Track-Designation-for-177Lu-PNT2002-for-the-Treatment-of-Metastatic-
Castration
-Resistant-Prostate-Cancer.html?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter
https://www.globenewswire.com/news-release/2023/04/24/2652585/0/en/Lantheus-and-POINT-Biopharma-Announce-FDA-Grants-Fast-Track-Designation-for-177Lu-PNT2002-for-the-Treatment-of-Metastatic-
Castration
-Resistant-Prostate-Cancer.html?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter
Scout4answers
in
Advanced Prostate Cancer
1 year ago
My reaction to Crestor & Nubeqa combo. I need to make some adjustments. This study says simvastatin is best against APC. Your thoughts?
In
castration
-resistant LNCaPabl cells, enzalutamide combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of enzalutamide in 22Rv1 cells.
In
castration
-resistant LNCaPabl cells, enzalutamide combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of enzalutamide in 22Rv1 cells.
GeorgeGlass
in
Fight Prostate Cancer
1 year ago
Pluvicto does not work better if used before docetaxel in mCRPC
More information on optimal sequencing - it doesn't matter which is used before the other in chemo-naive men who are metastatic and
castration
-resistant (mCRPC). https://www.prostatecancer.news/2023/09/pluvicto-does-not-work-better-if-used.html
More information on optimal sequencing - it doesn't matter which is used before the other in chemo-naive men who are metastatic and
castration
-resistant (mCRPC). https://www.prostatecancer.news/2023/09/pluvicto-does-not-work-better-if-used.html
Tall_Allen
in
Advanced Prostate Cancer
10 months ago
Supraphysiological Androgens [SPA] Promote Tumor Suppressive Activity of the AR Through cMYC Repression and Recruitment of the DREAM Complex
Conversely, androgen deprivation in vitro and
castration
in vivo led to rapid and persistent increases in MYC. The expression of MYC and of MYC-regulated genes is also increased in CRPC, including in clinical samples without MYC gene amplification.
Conversely, androgen deprivation in vitro and
castration
in vivo led to rapid and persistent increases in MYC. The expression of MYC and of MYC-regulated genes is also increased in CRPC, including in clinical samples without MYC gene amplification.
pca2004
in
Fight Prostate Cancer
1 year ago
Olaparib for Metastatic Castration-Resistant Prostate Cancer With BRCA1 and/or BRCA2 Alterations
Olaparib monotherapy improved outcomes in patients with metastatic
castration
-resistant prostate cancer with BRCA alterations, regardless of their subgroup (zygosity, germline, or somatic).
Olaparib monotherapy improved outcomes in patients with metastatic
castration
-resistant prostate cancer with BRCA alterations, regardless of their subgroup (zygosity, germline, or somatic).
Balsam01
in
Advanced Prostate Cancer
7 months ago
Hypogonadism After Prostatectomy
A level of 50 or below is
castration
level.
A level of 50 or below is
castration
level.
Hidden
in
Prostate Cancer And Gay Men
1 year ago
ART ADT n Life Without Testosterone for Prostate Cancer Patients
MIN 8:36 ADT Impact Libido Study – Study of 400 young healthy men treated w Lubron;
castration
TET achieved. Separated into 5 groups, one group given no TET and the other 4 increasing levels of TET replacement. Libido was correlated to TET levels; the lower the less Libido reported.
MIN 8:36 ADT Impact Libido Study – Study of 400 young healthy men treated w Lubron;
castration
TET achieved. Separated into 5 groups, one group given no TET and the other 4 increasing levels of TET replacement. Libido was correlated to TET levels; the lower the less Libido reported.
RMontana
in
Active Surveillance - Prostate Cancer
1 year ago
Thromboxane & Aspirin
"We found a consistent decrease of in vivo formation of thromboxane by approximately 40% during parenteral oestrogen therapy ... and a doubling after surgical
castration
."
"We found a consistent decrease of in vivo formation of thromboxane by approximately 40% during parenteral oestrogen therapy ... and a doubling after surgical
castration
."
pca2004
in
Fight Prostate Cancer
1 year ago
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