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Clinical Implications of New Data on Apalutamide + ADT in Castrate-Sensitive Prostate Cancer
So, these two drugs belong to androgen receptor potent AR inhibitor and for the first time, this drug was tested in this metastatic
castration
-sensitive prostate cancer setting and what we see was really remarkable.
So, these two drugs belong to androgen receptor potent AR inhibitor and for the first time, this drug was tested in this metastatic
castration
-sensitive prostate cancer setting and what we see was really remarkable.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Protein that hinders advancement of prostate cancer identified.
Researchers at Boston University School of Medicine (BUSM) have discovered that blocking a specific protein, may be a promising strategy to prevent the spread of
castration
-resistant prostate cancer (CRPC). https://www.sciencedaily.com/releases/2019/05/190520125753.htm
Researchers at Boston University School of Medicine (BUSM) have discovered that blocking a specific protein, may be a promising strategy to prevent the spread of
castration
-resistant prostate cancer (CRPC). https://www.sciencedaily.com/releases/2019/05/190520125753.htm
Pierreb
in
Advanced Prostate Cancer
5 years ago
ARV-110 Fast tracked for mCRPC
(ARVN)By: Mamta Mayani, SA News Editor The FDA has granted Fast Track designation to Arvinas' (NASDAQ:ARVN), lead PROTAC protein degrader, ARV-110, for the treatment of men with metastatic
castration
-resistant prostate cancer (mCRPC) whose disease has progressed after treatment with two or more systemic
(ARVN)By: Mamta Mayani, SA News Editor The FDA has granted Fast Track designation to Arvinas' (NASDAQ:ARVN), lead PROTAC protein degrader, ARV-110, for the treatment of men with metastatic
castration
-resistant prostate cancer (mCRPC) whose disease has progressed after treatment with two or more systemic
Longterm101
in
Advanced Prostate Cancer
5 years ago
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Enzalutamide With Standard Therapy in Metastatic Prostate Cancer
BACKGROUND Enzalutamide, an androgen-receptor inhibitor, has been associated with improved overall survival in men with
castration
-resistant prostate cancer.
BACKGROUND Enzalutamide, an androgen-receptor inhibitor, has been associated with improved overall survival in men with
castration
-resistant prostate cancer.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Rapid PSA decrease?
And now one of those hard questions: How long does it generally take to become
castration
resistant? I assume it depends on a whole lot of factors, and it can probably vary a lot even for the same factors. But I don't have a clue, so please help me with some sort of guidance.
And now one of those hard questions: How long does it generally take to become
castration
resistant? I assume it depends on a whole lot of factors, and it can probably vary a lot even for the same factors. But I don't have a clue, so please help me with some sort of guidance.
Gearhead
in
Advanced Prostate Cancer
5 years ago
Local Ablative Radiotherapy Reverts CRPC to Earlier Disease Stage
elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MjE1MTA5NDQ5Nzg2S0&lid=10332481 After radiation 73% of the 15 patients analysed had a decreased PSA value in spite of being
castration
resistant. 6 patients got
elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MjE1MTA5NDQ5Nzg2S0&lid=10332481 After radiation 73% of the 15 patients analysed had a decreased PSA value in spite of being
castration
resistant. 6 patients got
GP24
in
Advanced Prostate Cancer
5 years ago
Thinking about Starting Xtandi Question
Meyers Videos on Prostate Cancer Treatments he has used for years including his patients and his own complete durable remission of
Castration
Resistant PC. Appreciate if anyone out there would happen to know if Dr.
Meyers Videos on Prostate Cancer Treatments he has used for years including his patients and his own complete durable remission of
Castration
Resistant PC. Appreciate if anyone out there would happen to know if Dr.
tgrec
in
Advanced Prostate Cancer
5 years ago
ZYTIGA (abiraterone acetate) vs Mylan's generic abiraterone vs Yonsa
Sun Pharma's Yonsa is approved to be used in combination with methylprednisolone for the treatment of patients with metastatic
castration
-resistant prostate cancer (mCRPC). Yonsa contains the same active ingredient of Zytiga, also used to treat prostate cancer.
Sun Pharma's Yonsa is approved to be used in combination with methylprednisolone for the treatment of patients with metastatic
castration
-resistant prostate cancer (mCRPC). Yonsa contains the same active ingredient of Zytiga, also used to treat prostate cancer.
cesanon
in
Advanced Prostate Cancer
5 years ago
Enzalutamide & Abiraterone ... higher T = more favorable prognosis.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated
Castration
-Resistant Prostate Cancer.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated
Castration
-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Local Ablative Radiotherapy Reverts CRPC to Earlier Disease Stage
European Association of Urology Can Local Ablative Radiotherapy Revert
Castration
-Resistant Prostate Cancer to an Earlier Stage of Disease?
European Association of Urology Can Local Ablative Radiotherapy Revert
Castration
-Resistant Prostate Cancer to an Earlier Stage of Disease?
Balsam01
in
Advanced Prostate Cancer
5 years ago
Clinical Utility of CTC AR-V7 Status in mCRPC
PATIENT SUMMARY Liquid biopsies that determine circulating tumour cell androgen receptor splice variant-7 status have the potential to impact treatment decisions in metastatic
castration
-resistant prostate cancer patients.
PATIENT SUMMARY Liquid biopsies that determine circulating tumour cell androgen receptor splice variant-7 status have the potential to impact treatment decisions in metastatic
castration
-resistant prostate cancer patients.
Balsam01
in
Advanced Prostate Cancer
5 years ago
AR-V7 and Circulating Tumor Cell DNA Testing - Availability and Use
I am also considering initiating therapy with the next treatment before
castration
resistance fully develops (please see evolutionary and game theory posts by fellow members on this forum, highly recommended).
I am also considering initiating therapy with the next treatment before
castration
resistance fully develops (please see evolutionary and game theory posts by fellow members on this forum, highly recommended).
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
3 Years Post Diagnosis.
About 6 months later (1.5 years after diagnosis) my PSA tarted to rise rapidly whilst o Zoladex and I was declared '
castration
resistant'.
About 6 months later (1.5 years after diagnosis) my PSA tarted to rise rapidly whilst o Zoladex and I was declared '
castration
resistant'.
paulofaus
in
Advanced Prostate Cancer
5 years ago
Periprostatic Fat & ADT
The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by
castration
therapies is missing.
The connection between androgen deprivation therapy, obesity, inflammation, and prostate cancer progression is well-established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by
castration
therapies is missing.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in
Castration
-Resistant Prostate Cancer Bryden Considine, DODaniel P.
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in
Castration
-Resistant Prostate Cancer Bryden Considine, DODaniel P.
JLS1
in
Advanced Prostate Cancer
5 years ago
T levels and Zytiga
My understanding is that 50 ng/dl is considered
castration
level, but with prostate cancer you really want to try to get it under 20. My test came back at "<7", which means I don't have enough T for the test to detect.
My understanding is that 50 ng/dl is considered
castration
level, but with prostate cancer you really want to try to get it under 20. My test came back at "<7", which means I don't have enough T for the test to detect.
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Has anyone done docetaxel with ADT as a first line treatment?
Also, are there any trials or studies right now for using these drugs prior to demonstrated
castration
-resistance?
Also, are there any trials or studies right now for using these drugs prior to demonstrated
castration
-resistance?
CantChoose
in
Advanced Prostate Cancer
5 years ago
Metastatic Castration-Sensitive Prostate Cancer: Optimizing Patient Selection and Treatment
https://ascopubs.org/doi/full/10.1200/EDBK_200967 Thought this was the best summary I've read yet. Has all the trials and medications.
https://ascopubs.org/doi/full/10.1200/EDBK_200967 Thought this was the best summary I've read yet. Has all the trials and medications.
CantChoose
in
Advanced Prostate Cancer
5 years ago
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone Patients with a diagnosis of metastatic prostate cancer who have not been told they are
castration
-resistant, are needed to participate in a 60-minute phone interview using a computer at the end of May.
Two Paid Research Opportunities $1025 for Chicago residents and $100 for anywhere by phone Patients with a diagnosis of metastatic prostate cancer who have not been told they are
castration
-resistant, are needed to participate in a 60-minute phone interview using a computer at the end of May.
Darryl
Partner
in
Advanced Prostate Cancer
5 years ago
TAT-11: Expanding the Horizon of Targeted Alpha Therapy with Thorium Conjugates
Bayer currently has Xofigo, a drug using Radium-223(Cl2) approved in 54 countries for the treatment of patients with
castration
-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
Bayer currently has Xofigo, a drug using Radium-223(Cl2) approved in 54 countries for the treatment of patients with
castration
-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
tango65
in
Advanced Prostate Cancer
5 years ago
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