combining Abiraterone with Avadart have synergistic benefit

[George71]

"Armed with new insights into how metastatic prostate tumors gain resistance to the next-generation androgen inhibitor abiraterone, Cleveland Clinic oncologist Nima Sharifi, MD, has discovered a way to make the drug’s activity more durable and potent.

Pairing abiraterone (abi) with the enzyme inhibitor dutasteride modifies abi’s metabolic conversion, blocking production of a tumor-promoting metabolite while aiding accumulation of another metabolite with strong anti-tumor effects, Dr. Sharifi and colleagues report in Nature. The study builds on his extensive previous research into prostate oncogenesis.

“These findings hold enormous potential for changing the way abiraterone is prescribed to patients,” says Dr. Sharifi who holds the Kendrick Family Endowed Chair for Prostate Cancer Research and is the study’s senior author. “While more work is needed to determine the ultimate clinical effect of biochemically altering abiraterone metabolism in this way, our team has identified a promising new combination therapy that stands to improve the care of men with metastatic castration-resistant prostate cancer.”

consultqd.clevelandclinic.o...

[tango65]

Very interesting. Thanks for posting. I am not in abiraterone but I am taking avodart like many ohers in the place.

[George71 in reply to tango65]

Yes, I'm on Avadart only too. I'm hoping it won't come to abiraterone til after 2050 LOL

[NPfisherman]

I am on Abiraterone and will not be taking "no" for an answer on dutasteride... Thanks for posting, George....

Fish

[j-o-h-n]

Great News...... now if I only knew what it meant.....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 06/16/2019 11:39 PM DST

[rococo]

Since avodart works with Abby might it work with Xtand I which is cross resistant or Lupron both of which many of our brothers are on. Hope so. Rocco