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CRISPR news: protein arginine methyltransferase 7 as a novel essential gene in prostate cancer metastasis (in vitro)
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Now, tell me how to deal with it! https://pubmed.ncbi.nlm.nih.gov/38432581/
Maxone73
in
Advanced Prostate Cancer
2 days ago
CAR-T: new phase 1 trial will soon start to enroll
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) Promising preclinical tests, but it's a phase 1 trial https://clinicaltrials.gov/study/NCT04249947
Maxone73
in
Advanced Prostate Cancer
2 days ago
Surgery or radiation, looking for some advices
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Hi everyone, I’m looking for some advices for my father. He was recently diagnosed with prostate cancer. He probably already had it for a long time. Quite high PSA (way over 20), and spread to multiple lymph nodes. The surgeon said surgery is still doable, followed by radiation. Radiation oncologist
Healing1826
in
Advanced Prostate Cancer
2 days ago
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Discomfort
Hi all. I'm getting discomfort in my upper abdomen. It's not pain exactly but it's uncomfortable. It's like IBS, which I suffer with, but can't take peppermint oil anymore. Has anyone else experienced this? Is it normal? It's not bloated like I had when I was diagnosed with cirrhosis. Apart from this
Hi all. I'm getting discomfort in my upper abdomen. It's not pain exactly but it's uncomfortable. It's like IBS, which I suffer with, but can't take peppermint oil anymore. Has anyone else experienced this? Is it normal? It's not bloated like I had when I was diagnosed with cirrhosis. Apart from this
Littlelizzy11
in
British Liver Trust
3 days ago
Prolia shots
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
After 4+ years of Actonel is Prolia a good choice for continued treatment of osteoporosis? I will be asking my rheumatologist the same question next time I see her. I am due for another bone scan so she will most likely want to see that first but based on the first 2 tests I am going downhill bone-wise
Alebeau
in
PMRGCAuk
4 days ago
Pet Scan Below, Does Non Avid PSMA Liver Lesions mean possible Neuroendocrine Cancer
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
EXAM: PET-CT SKULL BASE TO MID-THIGH CLINICAL HISTORY: Metastatic prostate cancer, rising PSA TECHNIQUE: PET/CT skull base to thigh-subsequent treatment strategy F18 PYL dose: 10.00 millicuries Injection site: L AC Time of injection: 17:00 Time of emission scan: 18:06 Oral Contrast
Shorehousejam
in
Advanced Prostate Cancer
4 days ago
Urinary Issues
I have had urinary issues for a long time. Urgency, frequency, retention, pain. No "incontinence" if i can get to a toilet or get the dick out to pee on the ground fast enough. Every day is a different combination of the above and I have never been able to figure out what causes each symptom or how
I have had urinary issues for a long time. Urgency, frequency, retention, pain. No "incontinence" if i can get to a toilet or get the dick out to pee on the ground fast enough. Every day is a different combination of the above and I have never been able to figure out what causes each symptom or how
spencoid2
in
Advanced Prostate Cancer
5 days ago
Restless legs syndrome
Hi. Wondering if anyone knows if the following pain meds would trigger my rls.In south africa it's called synaleve: meprobamate and codeine Xefo: lornoxicam I'm not sure what UK brands are but these are the ingredients Many thanks
Hi. Wondering if anyone knows if the following pain meds would trigger my rls.In south africa it's called synaleve: meprobamate and codeine Xefo: lornoxicam I'm not sure what UK brands are but these are the ingredients Many thanks
AzraCG
in
Restless Legs Syndrome
5 days ago
Had Pet Scan, PSA rising 0.77 Found Liver Metastases, Am I a dead man? What can I do?
Going for MRI and Biopsy What can I do?
Going for MRI and Biopsy What can I do?
Shorehousejam
in
Advanced Prostate Cancer
5 days ago
Starting Chemo in May via trial
Thanks to everyone for all of their great questions and converstions on this site. Check my bio for background. 2 months into ADT therapy after diagnosis in January. I am starting docetaxyl chemo via an NIH trial in May. M9241 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230972/. We are hopeful
Thanks to everyone for all of their great questions and converstions on this site. Check my bio for background. 2 months into ADT therapy after diagnosis in January. I am starting docetaxyl chemo via an NIH trial in May. M9241 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230972/. We are hopeful
4tunate1
in
Advanced Prostate Cancer
8 days ago
microscopic haematuria
so about a month ago i was getting vaginal infections that cause soreness and itchyness as well as burning to wee. It was put down to a UTI and was given antibiotics.i also had pelvic pain on my right side that came and went like a stitch. It never cleared so I ended up have 3 lots of antibiotics. Every
so about a month ago i was getting vaginal infections that cause soreness and itchyness as well as burning to wee. It was put down to a UTI and was given antibiotics.i also had pelvic pain on my right side that came and went like a stitch. It never cleared so I ended up have 3 lots of antibiotics. Every
Jellycat123
in
Bladder Health UK
8 days ago
Librax side effects
Hello to the IBS Community,
😊 I hope this message finds you well. I'm reaching out because I've been navigating stress-induced IBS, and it's been quite a journey. The symptoms—pain, nausea, bloating, inflammation—have been challenging, to say the least. I have been feeling pain daily for months
Hello to the IBS Community,
😊 I hope this message finds you well. I'm reaching out because I've been navigating stress-induced IBS, and it's been quite a journey. The symptoms—pain, nausea, bloating, inflammation—have been challenging, to say the least. I have been feeling pain daily for months
RuthBlossom
in
IBS Network
9 days ago
A quick update for those that remember my recent posts about the Ablation complications!
Ablation 16/3, artery got damaged, 3 outpatient appointments, 2 failed attempts at thrombin infusion under ultrasound, emergency 3 day admission to hospital with emergency pseudoaneurysm and arteriovenous fistula repair (pretty major surgery involving patching the damaged artery with cow veins) . Most
Ablation 16/3, artery got damaged, 3 outpatient appointments, 2 failed attempts at thrombin infusion under ultrasound, emergency 3 day admission to hospital with emergency pseudoaneurysm and arteriovenous fistula repair (pretty major surgery involving patching the damaged artery with cow veins) . Most
AmandaLouise77
in
Atrial Fibrillation Support
12 days ago
European Medicines Agency approves Phase II trial of uTRACE in prostate cancer: good news because they also have uTREAT
While uTRACE is a diagnostic tool, its brother uTREAT will be a very interesting radioligand for drug delivery in the near future (like Actinium, Lutetium & Co) uTRACE is used as a PET-tracer ligand that targets the uPAR receptor, which is known to be a biomarker for cancer aggressiveness. https:
While uTRACE is a diagnostic tool, its brother uTREAT will be a very interesting radioligand for drug delivery in the near future (like Actinium, Lutetium & Co) uTRACE is used as a PET-tracer ligand that targets the uPAR receptor, which is known to be a biomarker for cancer aggressiveness. https:
Maxone73
in
Advanced Prostate Cancer
12 days ago
Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
13 days ago
10-year update still shows no benefit to ART vs early SRT
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
ART
= adjuvant radiation therapy, within 6 months after radical prostatectomy (RP)
early SRT
= salvage radiation therapy, after PSA ≥ 0.1ng/ml or 3 consecutive rises. Median was 0.2 ng/ml. Median 1 ½ years after RP. Patients risked nothing by waiting, and gained urinary and fecal continence
Tall_Allen
in
Advanced Prostate Cancer
15 days ago
Moving on to Provenge/Sipuleucel-t
We met with my husband's onc yesterday to discuss the next move since the 3 years of Abiraraterone/prednisone has run its course. His psa numbers are now around 2.0 (up from a low of .04) and psma scan indicates that bone met volume is quite low. A recent lab biopsy didn't reveal much... The good doc
We met with my husband's onc yesterday to discuss the next move since the 3 years of Abiraraterone/prednisone has run its course. His psa numbers are now around 2.0 (up from a low of .04) and psma scan indicates that bone met volume is quite low. A recent lab biopsy didn't reveal much... The good doc
Lavender22
in
Advanced Prostate Cancer
16 days ago
Ureter Restriction from Radiation Treatments?
While I don't have any symptoms (yet), a CT scan and ultrasound tests show that the lower part of my right ureter tube is very narrow and causing the kidney to swell, apparently from restricted flow of urine through the ureter. My University of Chicago Medicine urologist suspects scarring in the ureter
While I don't have any symptoms (yet), a CT scan and ultrasound tests show that the lower part of my right ureter tube is very narrow and causing the kidney to swell, apparently from restricted flow of urine through the ureter. My University of Chicago Medicine urologist suspects scarring in the ureter
Polaris1
in
Advanced Prostate Cancer
16 days ago
Suddenly Urinary Leakage just walking around, then I have to push / strain to urinate, PSA rising, prostatectomy leakage resolved
Can anyone give me an idea what is going on? No UTI, No Urinary Infections I was tested Suddenly having Urinary Leakage just walking around, then I have to push / strain, to urinate. I had a Radical Prostatectomy in 03/2023 leakage resolved. I didn’t have radiation as much as I was waiting
Can anyone give me an idea what is going on? No UTI, No Urinary Infections I was tested Suddenly having Urinary Leakage just walking around, then I have to push / strain, to urinate. I had a Radical Prostatectomy in 03/2023 leakage resolved. I didn’t have radiation as much as I was waiting
Shorehousejam
in
Advanced Prostate Cancer
17 days ago
Please help us decide on next treatment
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Simonapo
in
Advanced Prostate Cancer
17 days ago
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