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What is role of hormonal therapy drug when taken with targeted therapy, eg Piqray or Ibrance?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
HelenWi
in
SHARE Metastatic Breast Cancer
10 months ago
Stopped taking Orgovyx 7 months ago (T recovery only 80 baseline was 286 ) do I start TRT? am I risking Reoccurrence?
I stopped RT (IMRT 20 tx ) on 2/28/23. I stopped orgovyx (4 months) on 5/31/23 . (It has now been 6 months since stopping orgovyx. My T has recovered to 80. My baseline is 286.(which was fine) Advised when given choice of adt -4 months of orgovyxx- then 4 months for recovery of T- that didn't happen
I stopped RT (IMRT 20 tx ) on 2/28/23. I stopped orgovyx (4 months) on 5/31/23 . (It has now been 6 months since stopping orgovyx. My T has recovered to 80. My baseline is 286.(which was fine) Advised when given choice of adt -4 months of orgovyxx- then 4 months for recovery of T- that didn't happen
JWS13
in
Advanced Prostate Cancer
8 months ago
HRT and migraines
I'd be interested to know if there are women out there who can definitely say that taking HRT has helped them with migraines. I know that the research says that there is no evidence that it helps, if anything, probably makes it worse. Or were you prescribed some medication for menopause and it actually
I'd be interested to know if there are women out there who can definitely say that taking HRT has helped them with migraines. I know that the research says that there is no evidence that it helps, if anything, probably makes it worse. Or were you prescribed some medication for menopause and it actually
Chleo11
in
National Migraine Centre
8 months ago
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PSA rise soon after surgery!
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 50%) Ralp surgery robotic
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 50%) Ralp surgery robotic
Daddysgirl83
in
Advanced Prostate Cancer
11 months ago
Psa rise soon after surgery, help!
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 40%). Ralp surgery robotic
Writing regarding my dad. Worried and dont get any answers / just wait and see approach from medical team :( Dad 63 years old now, was diagnosed with prostate cancer october 2022. 2 small tumors 5x3 mm was shown on MR, no spread shown there. Biopsy showed gleason 3+4 ( 4 was 40%). Ralp surgery robotic
Daddysgirl83
in
Fight Prostate Cancer
11 months ago
Restless legs.
I have severe restless legs, as previously discussed within this forum. Over the past few years intercourse has become quite painful - middle age woman syndrome. Recently my GP started me on 10 milligrams estradiol vagifem pessaries. I understand that hrt has a significant impact on rls. My rls was
I have severe restless legs, as previously discussed within this forum. Over the past few years intercourse has become quite painful - middle age woman syndrome. Recently my GP started me on 10 milligrams estradiol vagifem pessaries. I understand that hrt has a significant impact on rls. My rls was
Trish8433
in
Restless Legs Syndrome
8 months ago
methotrexate
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling out
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling out
tresa56
in
NRAS
10 months ago
Favorite RA drug? I have so much anxiety about trying a new one
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling
tresa56
in
FieryBones - RA Community
10 months ago
Recurrence after prostatectomy
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
I have a relative who had surgery 6.5 years ago. Pathology was very favorable, 3+3+tertiary 4 i.e. less than 5%, no pos margins, no ECE, no nodes. He remained undetectable for 6.5 years, but now is .07 verified. What would SOC be for him? Prostate bed or wide radiation, length of ADT, just Lupron or
Fred312
in
Advanced Prostate Cancer
8 months ago
fed up of feeling so rubbish!!
Following up from previous posts: Brief history : diagnosed with hypothyroidism in March after going to the DRs initially thinking my HRT needed tweaking, awful brain fog, hair loss, brittle peeling ridged nails, cold feet but extreme sweating at times incl night sweats, dry flaky skin, horrible joint
Following up from previous posts: Brief history : diagnosed with hypothyroidism in March after going to the DRs initially thinking my HRT needed tweaking, awful brain fog, hair loss, brittle peeling ridged nails, cold feet but extreme sweating at times incl night sweats, dry flaky skin, horrible joint
Vorney
in
Thyroid UK
8 months ago
ADT working mechanism
I was just wondering, I heard dr. Richard Joel Wassersug Saying that ADT works well and better if you continue with it but if you start and stop, start and stop, it doesn’t work as well. Did all of you from your own experiences found this to be the case based on your experiences? Thanks for any feedback
I was just wondering, I heard dr. Richard Joel Wassersug Saying that ADT works well and better if you continue with it but if you start and stop, start and stop, it doesn’t work as well. Did all of you from your own experiences found this to be the case based on your experiences? Thanks for any feedback
Ahk1
in
Advanced Prostate Cancer
8 months ago
thrombotic thrombocytopenic purpura (TTP)
Warriors: Recently, I posted about 1 year side effects. Thank you for all of your responses. My SEs got the best of me and I’m writing from a hospital bed. The current theory is I have TTP, which is associated with hormonal therapy. I wanted to write and see if any of you have had the misfortune
Warriors: Recently, I posted about 1 year side effects. Thank you for all of your responses. My SEs got the best of me and I’m writing from a hospital bed. The current theory is I have TTP, which is associated with hormonal therapy. I wanted to write and see if any of you have had the misfortune
TMcgee
in
Advanced Prostate Cancer
8 months ago
restricted urinary flow
Finished IMRT/ SBRT radiation to lymph nodes last week. Since then Ive begun have early AM restricted urinary flow - Very narrow stream. Rad Onc suggested tamsulosin or ibuprophen. MO, tamsulosin. Any work around for the early AM problem that I could take overnight? Ibuprophen has to be taken all
Finished IMRT/ SBRT radiation to lymph nodes last week. Since then Ive begun have early AM restricted urinary flow - Very narrow stream. Rad Onc suggested tamsulosin or ibuprophen. MO, tamsulosin. Any work around for the early AM problem that I could take overnight? Ibuprophen has to be taken all
kainasar
in
Fight Prostate Cancer
7 months ago
Changing thyroid treatment and Testogel
Hi, I wonder if anyone can advise and apologies in advance for the long story! I consulted a private Endocrinologist and started taking Liothyronine in early October 1 x 5mg tablet 3 times a day. I was also on 25mg levothyroxine, 4pumps of estrogel, 2 tablets of progesterone and 1/8 pack of testogel
Hi, I wonder if anyone can advise and apologies in advance for the long story! I consulted a private Endocrinologist and started taking Liothyronine in early October 1 x 5mg tablet 3 times a day. I was also on 25mg levothyroxine, 4pumps of estrogel, 2 tablets of progesterone and 1/8 pack of testogel
Blu-cat11
in
Thyroid UK
8 months ago
Is it safe to use red light / near infrared therapy if you have Graves' disease?
Hi all, First a little bit of background about me. I am 49, living in Ireland. I have Graves's disease diagnosed by an endocrinologist who did antibody test etc.. After diagnosis I underwent 18 months on Carbimazole and then came off for a couple of months but my T3 and T4 shot back up again (and TSH
Hi all, First a little bit of background about me. I am 49, living in Ireland. I have Graves's disease diagnosed by an endocrinologist who did antibody test etc.. After diagnosis I underwent 18 months on Carbimazole and then came off for a couple of months but my T3 and T4 shot back up again (and TSH
MyNameIsAugust
in
Thyroid UK
11 months ago
Adenomyosis, should I have hysterectomy?
The short version is that I have adenomyosis. I've always had heavy periods with period pains that make my thighs numb and require prescription painkillers. At the age of 44 I had some symptoms of perimenopause and tried HRT. After two years I came off and that seems to have triggered a strong reaction
The short version is that I have adenomyosis. I've always had heavy periods with period pains that make my thighs numb and require prescription painkillers. At the age of 44 I had some symptoms of perimenopause and tried HRT. After two years I came off and that seems to have triggered a strong reaction
mavenmi
in
Endometriosis UK
8 months ago
Prostate cancer treatment and IBS
Dear Friends and Sufferers! I've been diagnosed with prostate cancer and have the option of removing the prostate or radiotherapy with or without hormone treatment. Can anyone out there who has experience of these offer advise on their impact on IBS and bowel function? At the moment, I've got IBS looseness
Dear Friends and Sufferers! I've been diagnosed with prostate cancer and have the option of removing the prostate or radiotherapy with or without hormone treatment. Can anyone out there who has experience of these offer advise on their impact on IBS and bowel function? At the moment, I've got IBS looseness
merve1
in
IBS Network
8 months ago
I am still struggling with treatment decisions - Help please.
I am struggling to decide on my treatment. The main point of conflict is HT or not, and LDR Brachytherapy (if I am eligible - because of a previous HOLEP) or IMRT. I also wonder if I should push hard for a 10-day earlier consultation at the risk of bad feeling. I welcome advice. In the UK - Referral
I am struggling to decide on my treatment. The main point of conflict is HT or not, and LDR Brachytherapy (if I am eligible - because of a previous HOLEP) or IMRT. I also wonder if I should push hard for a 10-day earlier consultation at the risk of bad feeling. I welcome advice. In the UK - Referral
Nordman
in
Advanced Prostate Cancer
6 months ago
Soy concerns
Hi, I have been focusing on the nutrition posts to improve my diet as I have osteopenia. I am reading a lot of posts and articles saying to incorporate soy. I stay away from soy because of breast cancer risks. I don't have breast cancer but avoid any estrogen enhancing products/medication like hormone
Hi, I have been focusing on the nutrition posts to improve my diet as I have osteopenia. I am reading a lot of posts and articles saying to incorporate soy. I stay away from soy because of breast cancer risks. I don't have breast cancer but avoid any estrogen enhancing products/medication like hormone
Truth-seeker1951
in
Bone Health and Osteoporosis UK
8 months ago
Importance of ADT
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
vintage42
in
Advanced Prostate Cancer
7 months ago
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