Experiences with

Bezafibrate

PPAR drugs are sometimes used as an anti itch medication (Bezafibrate). There is increasing evidence though, that Bezafibrate can impair kidney function - it needs to be monitored closely. Drugs included in this PPAR class include Seladelpar, Fenfibrate, and Elafibranor.

Did you notice any unwanted side effect from bezafibrate, e.g. in kidneys? Thanks for sharing and stay healthy and motivated!

I take Bezafibrate for itch (life saver). I have embark on a fitness journey of Crossfit and after 12 months wish to improve even more. I am advised by my coach to take Creatine and that this is natural and improves performance and muscle recovery. Anyone take this?

Treatment with URSO and bezafibrate keeps things reasonably stable. I believe in vaccines so have taken 4 Covid shots up to April 22.Soon after April dose I developed very bad pains in hips, thighs, shoulders and upper arms.

I was switched to Bezafibrate when I couldn’t tolerate Urso or Ocaliva. It’s absolutely fine. However I seem to be gaining weight. Has anyone else had this?

Does anyone know if Bezafibrate can cause problems with your kidneys? Also if you can just stop it or if you need to gradually come off?

Hi all , not posted for a while but was wondering in anyone been trialled on Bezafibrate alongside Urso to try bring ALP down to near normal range ? It’s not licensed for PBC in Uk but according to Gastro has good evidence of helping ?

Hi I have PBC for past 4 years, non responder to urso but still take with bezafibrate.

My pharmacist did tell me that by taking them together the Bezafibrate May diminish the affect of the Ursodeoxycholic and I do tend to believe this to be authentic but other than that I am satisfied that to mix them is not going to cause any side affects in the future , hopefully.

Diagnosed 2012 PBC alp222 ALT 60 antibody pos On UCDA for lft since 2013 Bezafibrate my request since 2020 ( papers from Japan/ France Methotrexate for inflammatory arthritis ( i think related to PBC Coenzyme Q10 - fatigue 2021 LFT normal egfr69 lower end normal Well some fatigue run 5k x4 a week

I am on trial at QE and wondered if anyone knew of some sort of reciprocal arrangement in AU otherwise the cost of Urso and Bezafibrate is too high for me to pay if had to self fund.... Any info would be greatly appreciated

She is on pioglitazone, bezafibrate, telmisartan, and erythropoietin. She, unfortunately, is obese, and her hunger is becoming a real problem for us.

PBC-ers who want to stay informed with new articles about the promising Bezafibrate, please check: https://link.springer.com/article/10.1007%2Fs00535-020-01664-0 (Journal of Gastroenterology)

Everyone with PBC and increasing ALP should ask for the combi-therapy with Bezafibrat. Your doctor can prescribe it with the diagnosis: metabolic fat disorder, so to avoid that it is not yet approved for PBC, because studies are so expensive for this cheap medicine. (We all Pbc-ers have metabolic fat-disorder

I was happily taking my Ursofalk until 2017, when my Consultant told me I was virtually a non-responder and that he was going to try me on Bezafibrate as well as Ursofalk. The Bezafibrate I take is called Bezalip. I take three pills a day with meals.

I’m currently on the transplant list for irretractable itch it’s destroyed mentally and physically I’m on 100 sertaline.. sleeping tabs zopiderm bezafibrate and I take pirating. I’m feeling so miserable and down

She also change my Bezafibrate 400mcg to Atorvastatin 20mcg daily. I did tell her that I had taken Statins when my GP first diagnosed High Cholesterol (over 10years ago now) but the didn't agree with me, given me pain in the lower right leg and sleeplessness.

Anyone taking bezafibrate to lower your enzyme numbers have side effects like very painful leg and feeling really low. Just started this drug three weeks ago .

My consultant has just suggested that I should take 400mg Bezafibrate modified release tablet once a day. It is not something I have heard of and was just wondering if anyone else takes them and how they have got on with them. I already take 1000mg of Urso per day.

I think this also assists with my other pill taking, as I have to take Allopurinol (I do this at breakfast time), Bezafibrate (for cholesterol) and 100mg Enteric coated aspirin (I take these latter two pills after my evening meal.