Bezafibrate with Urso really helps

[gardenfun]

Everyone with PBC and increasing ALP should ask for the combi-therapy with Bezafibrat.

Your doctor can prescribe it with the diagnosis: metabolic fat disorder, so to avoid that it is not yet approved for PBC, because studies are so expensive for this cheap medicine.

(We all Pbc-ers have metabolic fat-disorder).

It helps so many of us Pbc-ers.!!

Get supervised under this additional therapy, as some people react with higher liver-labs. These then must stop or take less. Check at least after 2 weeks taking it.

See those Medical journals :

nejm.org/doi/full/10.1056/N...

nejm.org/doi/full/10.1056/N...

Scroll this one to see: conclusion.

Combi-therapy works wonders for me and also many others.Please give it a try.

[Dililiver]

Thank you gardenfun I don’t have PBC but have vanishing bile ducts secondary to an adverse antibiotic reaction. I’m on Urso but it’s early days. My LFTs are terrible so I’ll mention this article to my Hepatology team and see would it help.

[Candy12]

I was given this combination six months ago, it’s early days but my LFT’s are all back in the normal range for the first time in 9 years.

I think it’s too early to tell if it’s slowing any progression of the PBC, but for me my treatment plan is to keep any inflammation as low as possible therefore, for me it’s working. I don’t feel quite so fatigued either so that’s a good thing. I never itched 6 months ago so it’s hard to determine if it would have helped. ( I do itch now though , so obviously it’s not stopped it occurring). Take care.

[Hidden]

Good afternoon gardenfun,

May I ask all members to exercise caution and seek the advice of their own hepatologist prior to considering taking any new medication.

We would also suggest that any new medication should be prescribed by your own hepatologist to meet your own individual needs.

Best wishes,

Trust9

[gardenfun in reply to Hidden]

Yes, of course. This medication needs a prescription.

And yes, you are right that it must be considered individually.

It is just that some doctors even don't know about this combination-therapy and its success to many Pbc-ers. So it doesn't hurt to bring this up to the doctors to consider it as a possible therapy.

Thanks for bringing this topic up.

As I also wrote, you must be supervised after taking it in the beginning, as some people react with high LFT s and then must either stop or lower dose.

But it is a promising therapy and I think people should know about this.