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Benign prostatic hyperplasia
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Anyone treated with enzalutamide +cabazitaxel?
Hi, I have stage4b with extensive bone mets. I've had sequentially ADT+abiraterone; docetaxel+carboplatin; Pluvicto. PSA never got below 3. Latest CT bone scan shows progression in a few areas. RO will zap the progressing areas locally. MO suggested cabazitaxel (1st choice) or enzalutamide (discouraged
Hi, I have stage4b with extensive bone mets. I've had sequentially ADT+abiraterone; docetaxel+carboplatin; Pluvicto. PSA never got below 3. Latest CT bone scan shows progression in a few areas. RO will zap the progressing areas locally. MO suggested cabazitaxel (1st choice) or enzalutamide (discouraged
BeLikeWater
in
Advanced Prostate Cancer
3 months ago
Was there ever really a chance for a cure?
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
duxlubber
in
Advanced Prostate Cancer
7 months ago
Big company buys a clinical research company focused on Actinium 225 (and others) FPI-2265
astra-something buys a Canadian company because they hate Canadians...no, sorry...ok, I will sound like a financial advisor, but here it is: Astra-something has been working on other approaches to develop more targeted cancer treatments, including antibody-drug conjugates and RCs. "The deal has solid
astra-something buys a Canadian company because they hate Canadians...no, sorry...ok, I will sound like a financial advisor, but here it is: Astra-something has been working on other approaches to develop more targeted cancer treatments, including antibody-drug conjugates and RCs. "The deal has solid
Maxone73
in
Advanced Prostate Cancer
7 months ago
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Getting head around what to expect
I like to have facts. In times of stress I think Facts are our friend. Better to be prepared, mentally, physically, financially, with support systems, etc.. so looking for any insights as to what I should expect and prepare my husband, myself and my kids/family for in the weeks and months, years ahead
I like to have facts. In times of stress I think Facts are our friend. Better to be prepared, mentally, physically, financially, with support systems, etc.. so looking for any insights as to what I should expect and prepare my husband, myself and my kids/family for in the weeks and months, years ahead
Melzer2169
in
Advanced Prostate Cancer
5 months ago
PSA level from 4 (Dec 2023) to 22 (present)
Hello, I am posting on behalf of my father. He tested a level of 4 PSA back in Dec 2023; the doctor did not say much except try to keep your stress level down, etc. He felt things were feeling quite abnormal so went back to doctor April this year and tested a level of 8 PSA so he was finally referred
Hello, I am posting on behalf of my father. He tested a level of 4 PSA back in Dec 2023; the doctor did not say much except try to keep your stress level down, etc. He felt things were feeling quite abnormal so went back to doctor April this year and tested a level of 8 PSA so he was finally referred
Dodododo
in
Prostate Cancer Network
3 months ago
Brain Fog or Dimentia?
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Keeper70
in
Advanced Prostate Cancer
7 months ago
Seeking anyone familiar with aggressive small cell neuroendocrine prostate cancer and/or with lurbinectedin as 2nd line chemotherapy.
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
silver5
in
Advanced Prostate Cancer
7 months ago
Castrate Resistant
I know that patients who were started at beginning with combo of, say, Lupron plus abiraterone acetate are declared castrate resistant when PSA rises in certain ways and/or progression is shown on scans. However, for someone like me, who's been on Lupron only since diagnosis, am I not castrate resistant
I know that patients who were started at beginning with combo of, say, Lupron plus abiraterone acetate are declared castrate resistant when PSA rises in certain ways and/or progression is shown on scans. However, for someone like me, who's been on Lupron only since diagnosis, am I not castrate resistant
dhccpa
in
Advanced Prostate Cancer
4 months ago
TRUST IN HEALTHCARE : free registration at https://malecare.org/trust-in-healthcare
Malecare and Prostate Cancer Research (UK) Virtual Conference: TRUST AND HEALTHCARE WEDNESDAY, JUNE 26, 2024 on Youtube.com/Malecare 12 PM ET to 6:10 PM ET (New York time) Register with your email for free at https://malecare.org/trust-in-healthcare Prostate Cancer Research (PCR) is a patient-centric
Malecare and Prostate Cancer Research (UK) Virtual Conference: TRUST AND HEALTHCARE WEDNESDAY, JUNE 26, 2024 on Youtube.com/Malecare 12 PM ET to 6:10 PM ET (New York time) Register with your email for free at https://malecare.org/trust-in-healthcare Prostate Cancer Research (PCR) is a patient-centric
Darryl
Partner
in
Prostate Cancer Network
4 months ago
Phase 2 trial: Evaluation of Treatment Interruption After Response in mHSPC
"Patients are allowed to enrolle if they have a stable or falling prostate-specific antigen (PSA) level below 0.2 ng/mL and a castrate testosterone level under 50 ng/dL at baseline after having a PSA level of at least 5 ng/mL and a testosterone level of at least 150 ng/dL prior to the start of ADT. "
"Patients are allowed to enrolle if they have a stable or falling prostate-specific antigen (PSA) level below 0.2 ng/mL and a castrate testosterone level under 50 ng/dL at baseline after having a PSA level of at least 5 ng/mL and a testosterone level of at least 150 ng/dL prior to the start of ADT. "
Maxone73
in
Advanced Prostate Cancer
4 months ago
After Orgovyx
Age 76, diagnosed with advanced prostate cancer in December 2021. PSA was 8.6, but had zero symptoms. Started Orgovyx in February 2022 and received 25 treatments of external radiation therapy starting in March 2022. Treated in April 2022 with brachytherapy. Current PSA is negligible, but urologist
Age 76, diagnosed with advanced prostate cancer in December 2021. PSA was 8.6, but had zero symptoms. Started Orgovyx in February 2022 and received 25 treatments of external radiation therapy starting in March 2022. Treated in April 2022 with brachytherapy. Current PSA is negligible, but urologist
BubbaC
in
Prostate Cancer Network
4 months ago
When to Commence ADT and/or Androgen Blocking Therapy?
Greetings All - New to this forum but have followed the Healing Well PC forum since beginning treatment in 2018 and later began to follow Prostate Cancer News, Reviews and Views which referenced this forum. The details are provided below but my question is: At what ultra-sensitive (LabCorp) PSA level
Greetings All - New to this forum but have followed the Healing Well PC forum since beginning treatment in 2018 and later began to follow Prostate Cancer News, Reviews and Views which referenced this forum. The details are provided below but my question is: At what ultra-sensitive (LabCorp) PSA level
Biochem
in
Advanced Prostate Cancer
4 months ago
AI to predict clinical trials outcome
"Dr. Sabbagh explains that traditional endpoints like overall survival often require long follow-ups, delaying access to potentially life-saving treatments. His research leverages baseline clinical characteristics and PSA changes over four months to accelerate predictions of trial outcomes. " It would
"Dr. Sabbagh explains that traditional endpoints like overall survival often require long follow-ups, delaying access to potentially life-saving treatments. His research leverages baseline clinical characteristics and PSA changes over four months to accelerate predictions of trial outcomes. " It would
Maxone73
in
Advanced Prostate Cancer
4 months ago
Fatiqued and wiped out feeling
I started lupron injection 5 months ago and starting my second month on nubeqa. I am extremely fatiqued and feel wiped out all the time. No ambition to do anything. Climbing stairs is an efford have to force myself to get out of bed. Cannot sleep very well. When I get up it feels like I have not slept
I started lupron injection 5 months ago and starting my second month on nubeqa. I am extremely fatiqued and feel wiped out all the time. No ambition to do anything. Climbing stairs is an efford have to force myself to get out of bed. Cannot sleep very well. When I get up it feels like I have not slept
woppaginny
in
Advanced Prostate Cancer
7 months ago
Sclerosis due to cancer or treatment?
I recently developed sclerosis in my left hip area...painful to sit on a hard surface. PSMA tech wrote 'sclerosis developed consistent with treatment'. Oncologist seems unconcerned. I've read that sclerosis can sometime happen when ADT reduces tumor size, which means the bone has to adjust. The recent
I recently developed sclerosis in my left hip area...painful to sit on a hard surface. PSMA tech wrote 'sclerosis developed consistent with treatment'. Oncologist seems unconcerned. I've read that sclerosis can sometime happen when ADT reduces tumor size, which means the bone has to adjust. The recent
CoastalTex
in
Advanced Prostate Cancer
4 months ago
2nd pBAT cycle results: AR upregulation? Double strand breaks? Darolutamide?
Started 2nd pBAT cycle on 4-22-24 with a PSA of 0.62 measured 2 days earlier. All 6 injections were 50 mg eod of T propionate with .625 mg letrozole every 5th day as an aromatase inhibitor. The hiT cycle was cut short by 2 injections because of a plan to SBRT treat a pelvic lymph node chain that lit
Started 2nd pBAT cycle on 4-22-24 with a PSA of 0.62 measured 2 days earlier. All 6 injections were 50 mg eod of T propionate with .625 mg letrozole every 5th day as an aromatase inhibitor. The hiT cycle was cut short by 2 injections because of a plan to SBRT treat a pelvic lymph node chain that lit
Ichthus316
in
Fight Prostate Cancer
4 months ago
Next step options after lupron/zytiga failed
I have been on monthly Lupron for 7 years (starting in 2014) after the spread of prostate cancer to my bones following a prostatectomy in 2014. Lupron alone was very effective until December 2021. I then added Zytiga/Prednisone which had worked well. But current (June 2024) scans show substantial disease
I have been on monthly Lupron for 7 years (starting in 2014) after the spread of prostate cancer to my bones following a prostatectomy in 2014. Lupron alone was very effective until December 2021. I then added Zytiga/Prednisone which had worked well. But current (June 2024) scans show substantial disease
sleepless-in-seattle
in
Advanced Prostate Cancer
4 months ago
Targeted Biopsy
I live on the east coast of North Carolina. I’m looking for top choices of medical centers that conducts MRI targeted biopsies. I’ve been on active surveillance for 10 years but last three PSA tests have been rising. I’m currently being treated at Duke Medical but want to ensure best care for targeted
I live on the east coast of North Carolina. I’m looking for top choices of medical centers that conducts MRI targeted biopsies. I’ve been on active surveillance for 10 years but last three PSA tests have been rising. I’m currently being treated at Duke Medical but want to ensure best care for targeted
Scvol
in
Prostate Cancer Network
4 months ago
Can medication elevate the PSA?
My PSA at time of the cancer diagnosis was 5.56. Being in the hospital right now with several meds surging through me, the PSA is at 348.00. Is this a normal reaction?
My PSA at time of the cancer diagnosis was 5.56. Being in the hospital right now with several meds surging through me, the PSA is at 348.00. Is this a normal reaction?
PARKER3237
in
Advanced Prostate Cancer
4 months ago
Estrogen for Bone Health in PCa patient.
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
binati
in
Advanced Prostate Cancer
4 months ago
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