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Confused about how all the different PCa drugs work?
This recent article (Oct 2023) has a nice high level diagram that organizes the more common prostate cancer drugs and their mechanism of action. Scroll down to Figure 1. De Novo Metastatic Prostate Cancer: Are We Moving toward a Personalized Treatment? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605467
This recent article (Oct 2023) has a nice high level diagram that organizes the more common prostate cancer drugs and their mechanism of action. Scroll down to Figure 1. De Novo Metastatic Prostate Cancer: Are We Moving toward a Personalized Treatment? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605467
skiingfiend
in
Advanced Prostate Cancer
8 months ago
Docataxel now
I am a 80 year old cheerleader for Docataxel. First treatment was Jan. 27, 2021. 16th treatment was yesterday, November 14, 2023…….I feel GREAT…….they started adding Dexamethasone on infusion and it is a game changer. …a12-18 hour window of no pain from the DEXA….Normal sequence is 21 days apart for
I am a 80 year old cheerleader for Docataxel. First treatment was Jan. 27, 2021. 16th treatment was yesterday, November 14, 2023…….I feel GREAT…….they started adding Dexamethasone on infusion and it is a game changer. …a12-18 hour window of no pain from the DEXA….Normal sequence is 21 days apart for
Leader4077
in
Advanced Prostate Cancer
8 months ago
Prostate Cancer Highlights from ESMO23
For those interested in the outcomes of recent prostate cancer trials or those just curious about the current thinking on 'where to next' the latest GU Cast podcast from Declan Murphy is well worth watching. The presentation is ‘peppered’ with conversation from the various speakers interviewed that
For those interested in the outcomes of recent prostate cancer trials or those just curious about the current thinking on 'where to next' the latest GU Cast podcast from Declan Murphy is well worth watching. The presentation is ‘peppered’ with conversation from the various speakers interviewed that
marnieg46
in
Fight Prostate Cancer
8 months ago
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Bummed, PSA went up 0.08 in a Week! Am I failing ADT?
Ok being dramatic Rising PSA? So damn soon? 15 months in Gleason 8/9 Low Volume High Grade History Dx 07/01/2022 Firamagon @28 days Zytiga with prednisone daily Metformin 500 mg daily Completed 6 Sessions of Docetaxel by 01/06/2023 Davinci RP w/ PLNR surgery 03/14/2023 No Supplements
Ok being dramatic Rising PSA? So damn soon? 15 months in Gleason 8/9 Low Volume High Grade History Dx 07/01/2022 Firamagon @28 days Zytiga with prednisone daily Metformin 500 mg daily Completed 6 Sessions of Docetaxel by 01/06/2023 Davinci RP w/ PLNR surgery 03/14/2023 No Supplements
Shorehousejam
in
Advanced Prostate Cancer
8 months ago
PSMA PET Scan - Help Interpreting Report?
Hello, My husband had his first PSMA PET scan done today, and I am hoping someone who understands PSMA PET reports can help us interpret/understand the results as well as what to expect or ask for in terms of any further testing and/or treatment? My profile is updated with his history, but in a nutshell
Hello, My husband had his first PSMA PET scan done today, and I am hoping someone who understands PSMA PET reports can help us interpret/understand the results as well as what to expect or ask for in terms of any further testing and/or treatment? My profile is updated with his history, but in a nutshell
FaithOverFear104
in
Advanced Prostate Cancer
8 months ago
Pericardial Window
I had my 2cd thoracentesis. It was more painful and for a very long time. They did drain a little more 950 ml. I am waiting for a thoracic surgery appointment. We will discuss possible placement of a pleural catheter for drainage, possible pleurodesis. And something new: turns out a lot of the chest
I had my 2cd thoracentesis. It was more painful and for a very long time. They did drain a little more 950 ml. I am waiting for a thoracic surgery appointment. We will discuss possible placement of a pleural catheter for drainage, possible pleurodesis. And something new: turns out a lot of the chest
NPmary
in
SHARE Metastatic Breast Cancer
4 months ago
chest pain
hello warriors, I have a mass in my chest wall and lungs, diagnosed with MBC on Jan 2021 and on ibrance and anastrozole. Scans thus far have shown no further spread. My next scan is in Dec. I am experiencing chest pain in the area that my chest wall tumor is. Also sensitive to deep pressure/touch. Worried
hello warriors, I have a mass in my chest wall and lungs, diagnosed with MBC on Jan 2021 and on ibrance and anastrozole. Scans thus far have shown no further spread. My next scan is in Dec. I am experiencing chest pain in the area that my chest wall tumor is. Also sensitive to deep pressure/touch. Worried
bockiee
in
SHARE Metastatic Breast Cancer
8 months ago
No indication for Docetaxel ?
Helo All, thanks in advance for your usual help. Almost five years in this journey. RP in 2019, followed by SRT plus ADT for 6 mo. First recurrence in 2021, had RT in LN plus ADT for 8mo. Second recurrence in january this year, started ADT again plus Erleada in July. PSA undetectable last month. Zoladex
Helo All, thanks in advance for your usual help. Almost five years in this journey. RP in 2019, followed by SRT plus ADT for 6 mo. First recurrence in 2021, had RT in LN plus ADT for 8mo. Second recurrence in january this year, started ADT again plus Erleada in July. PSA undetectable last month. Zoladex
CarlosBrasil
in
Advanced Prostate Cancer
8 months ago
Lowered CA125 and a nugget of hope 🙏
After 2 chemo sessions of carbo & taxol plus Avastin, my blood test level has reduced from 750 to 586 which is the first positive news I have received since diagnosis mid December 👏 it has given me a huge boost! My CT scan is Tuesday 20 Feb to see if my huge mass has shrunk enough for surgery, if so
After 2 chemo sessions of carbo & taxol plus Avastin, my blood test level has reduced from 750 to 586 which is the first positive news I have received since diagnosis mid December 👏 it has given me a huge boost! My CT scan is Tuesday 20 Feb to see if my huge mass has shrunk enough for surgery, if so
Kazzh
in
My Ovacome
4 months ago
lower right abdominal pain
Hi Everyone, I am 24 years old, and been having stomach problems since last September (6 months), I have pain in the lower right side of the abdomen and sometimes I see drops of bright or streaks of red blood in my stool, and after poo*** my anus burns and itches, I noticed that blood only appears
Hi Everyone, I am 24 years old, and been having stomach problems since last September (6 months), I have pain in the lower right side of the abdomen and sometimes I see drops of bright or streaks of red blood in my stool, and after poo*** my anus burns and itches, I noticed that blood only appears
bianco9685
in
Colon Cancer Connected
4 months ago
New trial in the West Midlands seeks to diagnose early-stage ovarian cancer
Good morning everyone This post is to let you know about the SONATA trial which is looking at whether taking two blood tests together (CA125 and HE4), and using a calculation called ROMA, would diagnose ovarian cancer earlier. The researchers hope that the tests used in the SONATA trial will mean
Good morning everyone This post is to let you know about the SONATA trial which is looking at whether taking two blood tests together (CA125 and HE4), and using a calculation called ROMA, would diagnose ovarian cancer earlier. The researchers hope that the tests used in the SONATA trial will mean
OvacomeSupport
My Ovacome Team
in
My Ovacome
8 months ago
Gemcitabine and Avastin (no Carbo)
Hi everyone! For my mom's second recurrence, the doctor suggested Gemcitabine and Avastin without Carbo, as she got kidney issues and potential liver mets with the last regimen with Carbo+Caelyx. Has anyone used Gem and Avastin without Carbo? Was it effective? Did you have any side effects? Thank
Hi everyone! For my mom's second recurrence, the doctor suggested Gemcitabine and Avastin without Carbo, as she got kidney issues and potential liver mets with the last regimen with Carbo+Caelyx. Has anyone used Gem and Avastin without Carbo? Was it effective? Did you have any side effects? Thank
Centaur17
in
My Ovacome
4 months ago
First post and learning as much as possible
Hi My husband is 59 and I have added as much info to my Bio as possible about him and this journey. We just found out yesterday that he is BRCA2 positive from blood germline testing. This is the first time I have posted but I have been reading everything several times a day for a few months now. He
Hi My husband is 59 and I have added as much info to my Bio as possible about him and this journey. We just found out yesterday that he is BRCA2 positive from blood germline testing. This is the first time I have posted but I have been reading everything several times a day for a few months now. He
positive-thinking
in
Advanced Prostate Cancer
4 months ago
Treatment Decision: Now considering surgery
This is a follow up to my post of a month ago: https://healthunlocked.com/advanced-prostate-cancer/posts/150423856/my-journey-thus-far I really appreciated all of the great information this team provided when I was trying to decide between surgery and radiation. In the mean time I did a consultation
This is a follow up to my post of a month ago: https://healthunlocked.com/advanced-prostate-cancer/posts/150423856/my-journey-thus-far I really appreciated all of the great information this team provided when I was trying to decide between surgery and radiation. In the mean time I did a consultation
CavScout
in
Advanced Prostate Cancer
4 months ago
prostate metastasis
hello - please excuse me if I don’t use correct medical terms - I’m learning! My husband was diagnosed almost a year ago with stage 4 (via prostate biopsy) prostate cancer that had metastasized….. multiple bone areas affected per his 2 Nuclear Bone Scans, Cat Scans etc - his PSA was off the rails = 1343
hello - please excuse me if I don’t use correct medical terms - I’m learning! My husband was diagnosed almost a year ago with stage 4 (via prostate biopsy) prostate cancer that had metastasized….. multiple bone areas affected per his 2 Nuclear Bone Scans, Cat Scans etc - his PSA was off the rails = 1343
Myshadowgirl1
in
Advanced Prostate Cancer
8 months ago
Tumor Markers Trodelvy
Has anyone experienced tumor markers rising after 1st cycle of trodelvy?! Did they go back down after next cycle. Doc told me they could rise due to new chemo regimen and then they go back down because of tumor markers were overloaded. I’m a little worried. Internet says “Chemotherapy treatment can
Has anyone experienced tumor markers rising after 1st cycle of trodelvy?! Did they go back down after next cycle. Doc told me they could rise due to new chemo regimen and then they go back down because of tumor markers were overloaded. I’m a little worried. Internet says “Chemotherapy treatment can
MBorne1
in
SHARE Metastatic Breast Cancer
5 months ago
Mark Buckley
Problem start in May 2023. Diagnosed with prostate cancer in August 2023. Started Bicalutamide 30th August 2023. 1 tablet x daily. Ended 19th September 2023. Started Contiflo XL 24th August 2023. 1 x daily. Ended 22nd September 2023. Hormone Implant called Zoladex LA 10.8mg 6th September 2023,
Problem start in May 2023. Diagnosed with prostate cancer in August 2023. Started Bicalutamide 30th August 2023. 1 tablet x daily. Ended 19th September 2023. Started Contiflo XL 24th August 2023. 1 x daily. Ended 22nd September 2023. Hormone Implant called Zoladex LA 10.8mg 6th September 2023,
whatisontheriver
in
Advanced Prostate Cancer
8 months ago
We might for the first time really be thinking of cures of cancer’
https://www.michiganmedicine.org/health-lab/we-might-first-time-really-be-thinking-cures-cancer#msdynttrid=JdeyNzK9W1EXarzbI4PfjSKrxGZAlLluHGFLOcFqJyM When Max Wicha, M.D., was starting his career, oncology did not come highly recommended. "When I first got into this field about 40 years ago, I went
https://www.michiganmedicine.org/health-lab/we-might-first-time-really-be-thinking-cures-cancer#msdynttrid=JdeyNzK9W1EXarzbI4PfjSKrxGZAlLluHGFLOcFqJyM When Max Wicha, M.D., was starting his career, oncology did not come highly recommended. "When I first got into this field about 40 years ago, I went
KocoPr
in
Advanced Prostate Cancer
5 months ago
SMYD3 enzyme involved in metastases
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
Derf4223
in
Advanced Prostate Cancer
6 months ago
Update on trametinib (Mekinist) for low grade serous ovarian cancer
Good morning everyone We are delighted that NHS England has recommended that the MEK-inhibitor trametinib (Mekinist) should be routinely available as an off-label treatment option for adults with recurrent or progressive low grade serous ovarian cancer (LGSOC). This is for people who have received
Good morning everyone We are delighted that NHS England has recommended that the MEK-inhibitor trametinib (Mekinist) should be routinely available as an off-label treatment option for adults with recurrent or progressive low grade serous ovarian cancer (LGSOC). This is for people who have received
OvacomeSupport
My Ovacome Team
in
My Ovacome
8 months ago
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