Ambroxol cough suppressant repurposed for slow down progression or hopefully stop PD

[TL500]

Was this post here?My neurologist mentioned about this repurposed drug for Parkinson's. I searched and found this, but I haven't read it all.

cureparkinsons.org.uk/ambro...

More:

ucl.ac.uk/news/2023/jan/cou...

parkinsons.org.uk/news/park....

[CaseyInsights]

Use the search bar. It has been over three years since we first got word. Still awaiting definitive pronouncements 😰

[TL500 in reply to CaseyInsights]

ok. Thanks

[Boscoejean]

"Ambroxol has been approved as a safe and effective substance in the European Medicines Agency, but has not been approved in the USA by the Food and Drug Administration. Ambroxol is also not registered for use in Australia"

[TL500 in reply to Boscoejean]

Safe and effective for cough?

[Boscoejean in reply to TL500]

may be safe and effective but relatively unavailable

[Despe in reply to Boscoejean]

If you have an Amazon account, especially PRIME, you can get it at Amazonde.com. I have been ordering it for some time.

[ssrs in reply to Despe]

are you in the US? Interested for my Hwp. I couldn’t get amazonde.com to come up on my iPad.

Thanks!!

Shaunna

[Despe in reply to ssrs]

Yes, we are in the US. amazon.de/

[ssrs in reply to Despe]

Thanks Despe!! Do you have a link to the actual product that you order for your Hwp, please?

Thanks!

Shaunna

[Despe in reply to ssrs]

amazon.de/s?k=ambroxol+75+r...

[Boscoejean in reply to Despe]

okaaay so maybe customs doesn't screen everything since I have heard that in the past

[seamusw in reply to Despe]

does it work ?

[Despe in reply to seamusw]

The only way to find out is to stop it. Not inclined to.

[Coling in reply to Despe]

Do you notice any difference?

[Despe in reply to Coling]

Not me, my husband is the one with PD. As I said, stopping taking Ambroxol will be the only way to find out if he sees any difference. If not broken, why fix it?

[Isotope in reply to Boscoejean]

Approved for cough but not PD…..as Dr Laurie Mischley said “once a drug is found that has benefits it takes 17 years to reach clinical use”….by than I will be a statue with no dopamine neurons left to salvage!

[JayPwP in reply to Isotope]

By then you will be much better than what you are today

[seamusw in reply to JayPwP]

I hope your optimism is correct ! Thanks

[TL500 in reply to JayPwP]

You mean with taking ambroxol?

[JayPwP in reply to TL500]

With / without...

In any case there's no option but to get better

[hussheid in reply to Boscoejean]

Not available? I found it for sale on Amazon.

[Boscoejean in reply to hussheid]

maybe you could order it but maybe it would be confiscated?

"No, it is not legal to order ambroxol in the United States without a prescription from the FDA:

The FDA has not approved ambroxol for sale in the U.S.

It is illegal to import drugs or devices into the U.S. for personal use without FDA approval

The FDA has identified websites that illegally market ambroxol

Ambroxol is a generic drug that has been used in Europe and most of the world since the late 1970s. It is an over-the-counter medicine that reduces mucus in respiratory diseases. The FDA has not approved ambroxol because it has not granted reciprocal recognition to generic medications approved by the European Medicines Agency. Drug companies would need to sponsor costly clinical trials to get FDA approval for ambroxol, which is not economical for a generic drug.

The FDA has warned consumers against using OTC cough and cold medications in children under 2 years of age"

[hussheid in reply to Boscoejean]

Thanks for the heads-up.

[Despe in reply to Boscoejean]

FDA needs big pharma's OK!!!!!!!!!!!!!!!!!!!!!!!!!! Hopefully, things will change soon. . . .

[Boscoejean in reply to Despe]

I think it was okay in the US at one time and taken off due to issues with babies or small children

[jeffreyn]

It is my understanding that the big (N=330) ambroxol Phase 3 trial (ASPro-PD) will begin recruitment early next year (2025).

clinicaltrials.gov/study/NC...

[CuriousMe12 in reply to jeffreyn]

Yes and it is a UK study based on an already available cough medicine.

[Boscoejean in reply to CuriousMe12]

so if you live in the UK you may be able to get in the study but if you live elsewhere this is not an option

[CuriousMe12 in reply to Boscoejean]

Yes. This is an extract from their update

Letter extract for study

[TL500]

Thanks everyone for your input.

[SilentEchoes]

Ambroxol calms the cytokine storm that is triggered in neurodegenerative disease (and the virus du jour) through various mechanisms. It is a natural plant medicine. Put ambroxol/cytokine in your web browser to find more information.

[TL500 in reply to SilentEchoes]

Thanks

[Despe in reply to SilentEchoes]

SE, Big pharma will scold you, hahaha.

[ssrs in reply to Despe]

👍🏻😂

[MarionP]

Something must be amiss in communication, I've always been able to buy it over the counter here in the US, in the US it's called Guaifenesin. I even think I have some in my closet now.

.

Not a cough suppressant, it's a companion, an expectorant, they add it to cough syrup to thin out that the sticky phlegm so that you can get some productive-ness in your coughing so the phlegm can be transported out of your trachea during upper respiratory infections...where it gets very thick and hard to get moving out of your trachea. You pretty much have to have it to go along with the cough suppressant (either the weak cough suppressant the antihistamine called dextromethorphan, or the stronger, more effective prescription med codeine, because the phlegm collects and builds into a kind of glue in your trachea that you must get out by coughing, but can't without it first being thinned out... So your cough suppressant cuts down on your coughing reflex, but now you are sort of getting drowned in this glue with no way to get out because it is just too thick for your cilia that move junk out of your trachea to actually do it, kind of like trying to do the job of a heavy shovel but with a toothbrush... therefore this expectorant. Before you end up losing your voice you will drop several octaves first because of the thickness of that sludge in your trachea. .

.

So that's Guaifenesin. I guess what you call ambroxol. It's available OTC in the U.S., but called Guaifenesin.

.

.

If you look around there usually is somewhere a version that has just this stuff in it and not the drug that works on suppressing your cough impulse. Not a great deal of demand for it but for example if you go to walmart, you will find one, maybe two, brands that have only this stuff in it. Pretty much at Walmart it's the Walmart house brand.

[jeffreyn in reply to MarionP]

Guaifenesin (an expectorant) and Ambroxol (a mucokinetic) are not the same thing. See Table 2 in the link below.

pmc.ncbi.nlm.nih.gov/articl...

[MarionP]

Yes, but I was hoping to stick to what are basically clinical effects with no side effects and and not have to get into the significant biochemistry. If you're going to get that technical about it then we are going to have to get into thrombospondins and their potential to unchain cancer cells so they can metastasize and build blood supplies through angiogenesis in their new locations... Which may have something to do with why ambroxol is not yet very popular with the FDA. That's not something you're going to find happens with guaifenesin, which seems to be without significant side effects of any kind (except in grossly excessive doses when combined with dextromethorphan). It's one thing to thin out phlegm through local sodium channel deactivation, but another thing to systemically deactivate calcium channel restraints on cancer proliferation.

Maybe the idea or the hope was to use ambroxol to attack cell walls of those misfolded alpha synuclein molecules to break them down so they can be transported out of the cell. If that was the plan perhaps it would make better sense to structural chemistry to try to modify the synuclein via crispr... Map the good son who clean, map the bad synuclein and then somehow fashion some kind of mechanism to revert the misfolded protein into the properly folded protein in place. maybe they were looking for ambroxol to be that carrier. Somehow they have to find a way to get that trigger into the cell.

[Fava-1]

very interesting study

[Nicopwp]

Ambrosan is a brand of ambroxol hydrochloride in 30mg tablets available on amazon. The study is using 420mg x 3 daily. Thats a lot of pills or am I missing something. It can also be found in liquid form in 120 ml bottles with 5ml = 30mg. That would be 65 ml x 3 = roughly 1.5 bottles daily!

[jeffreyn in reply to Nicopwp]

The Phase 2 trial required patients to take many tablets (more than 20 per day IIRC). The Phase 3 trial is using a re-formulation, to significantly reduce the number of tablets required.

[CRMACK1948 in reply to jeffreyn]

Backing up your comment I watched the presentation by the team involved in the research.You would need to be having a bottle a day to reach anything near the concentration that would theoretically help reduce Parkinson’s

[amykp]

Been taking it for years. We bought a large amount of the powder in bulk from India and I make my own capsules. Yes, the dose for PD is much higher than the dose for cough--about 1.2-1.4 grams or so. I don't think there is much point in taking a tiny dose each day. Save your money.

The reason it is not approved here yet is NOT because the FDA thinks there is anything wrong with it--it is because it is considered a "me too" drug, so nobody has bothered to try. As far as anyone cares about right now, it effectively does exactly the same thing that mucinex does, so it is not needed. It is not illegal to own, but it would be illegal to sell.

You can also order it from European pharmacies, but it is a pain in the neck to swallow a zillion pills.

Here's how they think ambroxol works: it is a "chaperone" drug. It causes a lysosomal enzyme called glucocerebrosidase to fold properly so it can do its job and clean up alpha-synuclein clogging and killing brain cells.

Lysosomes are little bags of enzymes (think: detergents) responsible for dissolving garbage inside cells, and glucocerebrosidase is one of the enzymes inside the little bags. Folks with PD often have defective (misfolded) glucocerebrosidase, so their lysosomes aren't up to snuff, thus they can't do their job. That is one theory for a cause of PD.

Does that make sense?

Also, recently, there seemed to be some evidence that ambroxol (completely unrelated) helps mitochondria stay healthy inside neurons as well, but I'm not sure how, yet.

Does it help me? Who knows? My progression is very slow, but I do a million other things: eat a keto diet, exercise like a crazy person, take a million other supplements, etc.

I can't wait for the trial. I think the problem was getting a single pill with enough of a dose, which confuses me, since how hard could it be to order the powder and fill capsules? I mean, I did it. These guys are professionals. Come on!!!!