3 current disease modifying stage 3 trials studies. But lactobacillus acidophilus ?

[CuriousMe12]

My understanding was that there were 3 disease modifying studies at phase 3 trial.1 Exenatide has failed.

2 Ambroxol is on going

3 lactobacillus acidophilus I can't find any study details for via google.

Does anyone know more ?

[LagLag37]

See if this is what you are looking for…..

search.app/dnp7fosWQLy1HnaEA

🥊

[CuriousMe12 in reply to LagLag37]

Thanks laglag but that looks like new levadopa delivery methods. Not disease modifying.I was after the study covering lactobacillus acidophilus. I assume it's probiotic targeting the gut.

[Obiora]

Biggest hopes are now Prasinezumab, a G-base enhancer such as ambroxol or another small molecule and stem cell grafts such as the Bluerock one

Prasinezumab open label extension looks quite promising and we will have data by the begining of 2025 of the new PASADENA trial

G-base enhancers will take at least 10 years to come, same as Bluerock, Prasinezumab maybe 3-5 years.

Exenatide news were really sad, but there is still hope folks!

Graph of prasinezumab open label study

[CuriousMe12 in reply to Obiora]

Yes Prasinezumab in phase2.I was hoping to find out about phase 3 entries in this pipeline chart.

Phase 3 disease modifiers

[Gcf51 in reply to CuriousMe12]

What's the source of this chart? I would like a clearer view – in hopes I can read it without the aid of a magnifying glass.

[jeffreyn in reply to Gcf51]

pubmed.ncbi.nlm.nih.gov/390...

[Gcf51 in reply to jeffreyn]

Your link "Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update", may be an interest to anyone reading this post.

Thanks, I will download an try to make large enough for me to read eith ease.

[CuriousMe12 in reply to Gcf51]

If looking on a smartphone just touch the picture to highlight it. Then two fingers together press on the picture, then slowly part your fingers. It should enlarge

[Gcf51 in reply to CuriousMe12]

Also works on a touch screen laptop.....

[Millbrook]

chartist recently posted about Fecal Microbiome Transplant (FMT) and there was a suggestion that the next best thing to this is actually taking a diversity of probiotics which we just started. Look up his posts. Sorry I can’t link it here cos not so savy

[CuriousMe12 in reply to Millbrook]

Yes there's been much general discussion on FMT and gut microbiome. But if there's a phase 3 trial ('re the diagram) targetting a specific lactobacillus acidophilus I'd expect to find more study literature on it.

[Gcf51 in reply to Millbrook]

Is this the one you are talking about. healthunlocked.com/cure-par...

[Millbrook]

healthunlocked.com/cure-par...

[CuriousMe12]

This looks like the one. Results in 2025. Egyptian.clinicaltrials.gov/study/NC...

Millbrook

Gcf51

Obiora

jeffreyn

[Gcf51]

I see no reference to strain, different strains of the same bacteria may have very different characteristics.