DO YOUR RESEARCH. Cure yourself. - Cure Parkinson's

Cure Parkinson's

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DO YOUR RESEARCH. Cure yourself.

pdefa profile image
23 Replies

PXN21 has worked wonders for all my symptoms. I have been having symptoms of Parkinson’s/IBS for several years now which have progressively gotten worse. Now mind you I’ve never been diagnosed with anything, the key thing is catching all these things early and treating them, not just treating the symptoms. Starting at around 21, I had dandruff/seborrheic dermatitis galore. I would itch my head off and flakes would keep coming. This has lasted 13+ years. My next symptom has been extreme constipation/drooling on pillow or in public/tiredness. I then started to notice twitching fingers and ejaculation problems. I’ve been to neurologists and they tell me I’m fine and not to worry. This is when you should be worried and fix the PROBLEM!!! Doctors don’t want to cure you, they would rather feed you worthless drugs for 30+ years that make the symptoms go away. Do yourself a favor and research all these things I’m about to write about. PXN21 inhibits alpha synuclein. Ambroxol that they’ve banned in the US cough medicines can prevent Parkinson’s. (No wonder they’ve banned it, seems sus.) PS128 reduces MPO an enzyme that plays an important role in the development of PD and other neurodegenerative diseases. Fecal transplants can do wonders. Numerous studies have demonstrated the efficacy of fermented foods like Kimchi, tempeh, red rice, pickled vegetables, fruits, etc., in managing AD (Not Parkinson’s but cool info). Probiotic formulations have been widely studied for their disease prevention and therapeutic effects. Various multi-strained probiotic formulations, including FRAMELIM, SLAB51, OMNi-BiOTiC, and OttaBac, have been shown to ameliorate neurodegenerative effects related to AD.

aSMase inhibitors stop Parkinson’s

Fluphenazine induces lysosomal stress and inhibits ASMase.

Siramesine have been shown to inhibit ASMase and have been proposed as anticancer drugs for the treatment of multidrug-resistant cancers.

aSMase inhibitors block the toxic signals of pro-inflammatory cytokines, protecting dopaminergic neurons from death and reduce cognitive impairment.

coffee improved MPTP-induced gut microbiota dysbiosis. These findings suggested that the neuroprotective effects of coffee on PD were involved in the regulation of gut microbiota, which might provide a novel option to elucidate the effects of coffee on PD.

Some newly researched neuroprotective agents for PD management include nicotine, melatonin, selenium, anti-inflammatory drugs, and iron chelators.

squalamine-shark oil

Farnesol, an antimicrobial compound found in herbs, fruits, and fungi prevents and reverses brain damage linked to Parkinson's disease

the progression of PD may be slowed by the administration of vitamin C and E.

Urolithin A (UA) is a gut metabolite shown to ameliorate geriatric diseases by increasing mitophagy and dampening inflammation.

The onset of Alzheimer's disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate.

baicalein, a flavonoid extracted from the Chinese herbal medicine Scutellaria baicalensis  is a potent inhibitor of α-syn oligomerisation both in cell-free and cellular systems, and is also an effective inhibitor of α-syn fibrillation in cell-free systems

KSOP1009, composed of eight medicinal plants of different families (Hamamelidaceae, Myristicaceae, Umbelliferae, Santalaceae, Piperaceae, Myrtaceae, Typhaceae, and Lamiaceae). MPTP is known to cause fast degeneration of dopaminergic neurons, and as such, it was believed that the use of this specific model could assist in explaining certain aspects of PD disease mechanisms [147,264]. Positive findings of the study demonstrated that ingestion of KSOP1009 was successful in the protection of MPTP toxicity, where this could be correlated with dopamine reduction that also decreases ROS and restores mitochondrial roles . They don’t want to tell you what makes up KSOP1009 because they want to make money and treat your symptoms. This is my list so far. I’m not a doctor and this is just info I’ve found on the web. Cure yourself, or drug companies will make thousands off of you, treating symptoms, instead of the underlying problem. Better yet, give all you’re money to Parkinson’s organizations that aren’t even looking for a cure.

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23 Replies
docjleonard55 profile image
docjleonard55

Has anyone made yogurt with PXN 21?

Rufous2 profile image
Rufous2 in reply todocjleonard55

I think to make yogurt a bacteria has to be able to consume lactose, which B. subtilis doesn't appear able to do;

microbewiki.kenyon.edu/inde....

"B. subtilis can ferment glucose, sucrose, but not lactose."

kaypeeoh profile image
kaypeeoh

I've had 40 years of practice reading medical studies. What I've learned is sometimes THEY LIE!. Easiest way is to leave off any contrary results. In college I had to repeat a study looking at LPS in rats. The original report showed LPS was toxic to rats. I did the entire study three times and was unable to kill any rats. So my resulting poor grade kept me from graduating cum laude. Later I found LPS is not toxic. LPS is lipopolysaccharide. One step in the study was washing the LPS in alcohol. That dissolved the lipid leaving only starch. So I was injecting starch into lab rats which did them no harm. But the original study supposedly proved LPS is toxic to rats. Like I said, sometimes researchers LIE and get away with it.

JayPwP profile image
JayPwP

And everyone will now rush to buy Bio-Kult 😆😆😆

Rufous2 profile image
Rufous2 in reply toJayPwP

Before rushing off to buy PX21, people hoping to recreate the alpha-synuclein thwarting effects that it had in C elegans should know that the authors of the original study stated that all B subtilis strains would appear to be effective. BioKult certainly isn't the most affordable strain.

I just started watching a Dr. Mischley video in which she emphasizes that most of the nutritional/supplemental things people are trying for PD are not likely to arrest disease (or, I take it, reduce motor symptoms) but slowing disease progression is a realistic goal. Determining which things make a difference in that regard is what her research is geared towards. Does anybody who follows Dr. M know what her stance is on probiotics in general, and this one in particular?

ncbi.nlm.nih.gov/pmc/articl...

"The Protective Effect against α-Syn Aggregation Is a General Property of B. subtilis species;

We therefore asked whether the observed effect on α-syn aggregation is unique to PXN21 or if it is shared among other strains of the B. subtilis species. We tested a panel of laboratory B. subtilis strains, including 168 (Zeigler et al., 2008), JH642 (Smith et al., 2014), and the undomesticated strain NCIB 3610 (Branda et al., 2001). All strains showed similar effects on α-syn aggregation to the probiotic strain PXN21 following the continuous or food-switching regime (Figures 2F and 2G), indicating that the anti-aggregation effect is a general property of the B. subtilis species."

PixelPaul profile image
PixelPaul in reply toRufous2

Im a patient of Dr. Mischley. I couple of years ago I asked her about probiotics. At that time she said there wasn’t enough understanding about them in regards to PD to be able to suggest any specific products.

Rufous2 profile image
Rufous2 in reply toPixelPaul

Thank you PixiePaul, that doesn't surprise me. There are so many probiotics out there....finding multiple people who've been taking a specific one seems like it would be very challenging.

JayPwP profile image
JayPwP in reply toRufous2

Thank you 🙏

pmmargo profile image
pmmargo

Im on gabapentin now. so far it s working. also for restless leg. best wishes

LynnP1974 profile image
LynnP1974

You’re so right! It’s so frustrating knowing that this illness has been around for decades and they’ve barely done anything to actually help people. Levodopa has been around for 30 years ( I believe) and that’s about it. My husband was recently diagnosed. He’s 52. In so frustrated trying to find out helpful info to help him. He’s not interested in starting levodopa yet due to all the other side effects it will eventually bring with it. We’re trying high dose B1 therapy, but not seeing any benefit as of yet. Still slowly increasing his dosage. Elliot Overton on YouTube has some great info on this. Thanks for your post. I will be looking into this.

Lynn

Nitro53 profile image
Nitro53 in reply toLynnP1974

Levodopa and the all side effects it will bring is a myth. Please research this!

LynnP1974 profile image
LynnP1974 in reply toNitro53

Dyskinesia isn’t a myth and neither are the “on” and “off times” that the meds cause. I know not everyone will experience obsessive compulsive issues, but it could happen as well.

Nitro53 profile image
Nitro53 in reply toLynnP1974

I’m sorry you didn’t understand my statement. I said Levadopa causing Dyskinesia is a myth. Also I never said anything about on/off times which I also experience, Entacapone has been a great help making the C/L last longer so fewer down times.

Juliegrace profile image
Juliegrace in reply toNitro53

Levodopa causing dyskinesia is not a myth. I can personally attest to that. I have suffered from levodopa induced dyskinesia (LID) from almost the beginning of taking levodopa. When I don’t take levodopa I don’t have dyskinesia. So it is not a myth. I believe you may be referring to the inevitability of LID, which is where there is disagreement. Not everyone will develop dyskinesia from taking levodopa, but certainly there are many who do.

WinnieThePoo profile image
WinnieThePoo in reply toJuliegrace

Actually it's dopamine that causes the dyskinesia , which of course is manufactured in our brains from the levadopa. So the levadopa is in the loop, but it's dopamine supplementation and not levadopa per se which is the problem. There were (and are) dyskenesia problems from the early stem cell transplants.

Moreover - I get the problem from the gloves. My wife pointed it out to me today. I had cut the gloves back to 2 hours a day, and with one thing and another been more like every other day, and I was starting to feel stiff and rigid, touch typing was grinding to a halt, it was an effort to walk from the gate to the house after a dog walk, and I was back up to 2xC/L tds (I nearly always forget the evening one). So I increased my glove time to try for 4 hours a day and have probably averaged 3, and kept the C/L unchanged

In addition to slight afternoon dystonia ( a sure sign of over-egging the C/L /glove mix) my wife noticed my left hand dyskenesia again. So - I had no dyskenesia from C/L and it was caused by the gloves. Of course - it's caused by a combination overload - not one item in the combo alone. (Mind you, there's smoke coming off this keyboard as I touch type!!)

But, dyskenesia is not exclusive to levadopa or dopamine.

Juliegrace profile image
Juliegrace in reply toWinnieThePoo

I wasn’t saying it was, only that it’s not a myth.

Esperanto profile image
Esperanto in reply toJuliegrace

As it turns out, levodopa-related dyskinesia is a result of dosage issues and/or the effectiveness of the medication due to interaction with other medications, aids, supplements, mood, etc. It is crucial to recognize and manage these factors. It can be challenging, but levodopa itself is not to blame. In that sense, it is indeed one of the myths described by J. Eric Ahlskog in 'Common Myths and Misconceptions That Sidetrack Parkinson Disease Treatment, to the Detriment of Patients'.

mayoclinicproceedings.org/a...

Juliegrace profile image
Juliegrace in reply toNitro53

What do you mean by this?

chartist profile image
chartist in reply toLynnP1974

Carbidopa/Levodopa became commercially available in 1975 or 49 years ago :

pubmed.ncbi.nlm.nih.gov/963....

A relevant quote :

' In the early 1970s, the advantages of adding a dopa decarboxylase inhibitor to treatment were discovered--reducing side effects and gaining better symptom control--and the first levodopa combination, carbidopa/levodopa, became commercially available in 1975. '

Art

Dabaa profile image
Dabaa

drweil.com/vitamins-supplem...

dick1van profile image
dick1van

On Melatonin. I don't feel different when on Melatonin, I take it for 1 It is a powerful antioxidant, neurogenesis, mitochondria biogenesis.

I also use it to prevent/treat viral and bacterial infections.

I recommend this book:

Extreme Dose! Melatonin The Miracle Anti-Aging Hormone Anti-Alzheimer’s Hormone Anti-Baldness Hormone Menopause Reversal Hormone.

I will know after I complete my first book on Preventing Parkinson's.

Dick Van Antwerp

BRAIN REGENERATION for Dementia & Parkinson’s

linkedin.com/groups/8451978/

Gcf51 profile image
Gcf51

Seems there is some research on PXN21. Has anyone had success with PXN21? I am not sure if  pdefa having never been diagnosed with anything would count as success.

"Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in young and aging animals and is partly mediated by DAF-16. Multiple B. subtilis strains trigger the protective effect via both spores and vegetative cells, partly due to a biofilm formation in the gut of the worms and the release of bacterial metabolites. We identify several host metabolic pathways differentially regulated in response to probiotic exposure, including sphingolipid metabolism. We further demonstrate functional roles of the sphingolipid metabolism genes lagr-1, asm-3, and sptl-3 in the anti-aggregation effect. Our findings provide a basis for exploring the disease-modifying potential of B. subtilis as a dietary supplement.

ncbi.nlm.nih.gov/pmc/articl...

I see   Rufous2 has posted this link....

RonB1 profile image
RonB1

I take Chinese Skullcap, which contains baicalein. This supplement is neuroprotective so it only makes sense to take it everyday.

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