Hi all,
It seems there are trials on this existing drug, used as a cough medicine, to establish if it can be repurposed as an effective PD drug.
I'm interested to hear from people who have tried this/ are trying this and to hear your experiences.
Many thanks,
Tony
Yes, tried for one year with full dose, no effect on me.
my husband has parkinism with lewey body and has been taking Ambroxol 75 g apsules twice a day for 12months his cognitive response improved and since dose has doubled he has improved imensly
Hi Doblady Can I ask what brand and where you sourced your product from ?
Hi Doblady, that is fantastic news. What symptoms do you think might have improved since starting with Ambroxol in addition to his cognition?
I think I need to increase now because in last month he’s been having those vacant sessions so he’s taking longer to process what is being said to him . Brand is Mucosan
Thanks Doblady, what does of Ambroxol has he been on recently?
Hi Doblady, how is your husband doing?
Hi
You say full dose
What it means?
Rose
clinical trials taking about 16 or 17 pill of 75 mg does per day
I ordered it but haven’t tried yet.
Im on it at the moment the max dose according to the trials phase 1, the safe doses is 1,2g/day
However the are I believe trials going on in phase 2 were the are up to 1,8g/day I am even up to 2,0g/d and no side effects.
I have no clear respons yet however I got the feeling that now after 4 months the my cognitive response improved I will at least take it for one year maybe (if no side effects) even longer
Im producing my own capsules and getting my ambroxol from India
Thank you for your response Lies Bram.
Did you say you are taking 2 g per day now?
Are you part of the trial or did you just decide yourself to try Ambroxol?
Tony
yes I am on 2g/day No Im not part part of a trial
Thanks, what prompted you / persuaded you to try it?
this Forum
Hi LiesBram, are you glad you are trying Ambroxol?
yes
What would you say are the upsides of taking Ambroxol for you personally?
this is different for any person I do not want to get peoples hopes up, simple said for me it seems to be doing something however I do believe you should try it for a longer period to get results, I just bought another 2 kg this should last me at least 3,5 years, my wife told me my motor skills are improving Im using 2g/day in the trials 1,2g/day is used which I tried also for half year, 0 effect
Are you on C/L?
??
Yes
Thank you LiesBram.
I was sourcing my Ambroxol from Germany but there appears to be a shortage of supply in Germany in the last 6 months, which has made it very difficult to obtain.
Are you able to advise where we can order a supply from in India?
Many thanks,
Mark
Im in the process of ordering 1 kg again if succesfull I can send you the details
Hi
Yes I would like to order it and when it’is possible for you to receive thé détails
Thanks
Rose
I just ordered 2kg
STATUT
Complété
LES CONDITIONS
Maladie de Parkinson
INTERVENTION / TRAITEMENT
Médicament: Ambroxol
DESCRIPTION DÉTAILLÉE
L'étude AiM-PD recrutera 20 patients (10 GBA-positifs et 10 GBA-négatifs) diagnostiqués avec la maladie de Parkinson (MP). Chaque patient s'auto-administrera le médicament à l'étude, l'ambroxol (60 mg par comprimé) à 5 augmentations de doses intra-dosées sur une période de 6 mois, comme indiqué ci-dessous :
Jour 1 à 7 : 60 mg trois fois par jour
Jour 8-14 : 120 mg trois fois par jour
Jour 15-21 : 180 mg trois fois par jour
Jour 22-28 : 300 mg trois fois par jour
Jour 29-186 : 420 mg trois fois par jour
Le médicament à l'étude est autorisé dans l'UE en tant que médicament en vente libre pour traiter les affections respiratoires en réduisant la production de mucus. Des études antérieures ont montré que l'ambroxol peut pénétrer dans le cerveau chez des modèles de rongeurs et de primates non humains, et peut avoir un effet sur le ralentissement de la MP. Les résultats indiquent également que les individus qui expriment la mutation GBA (risque accru de MP) sont capables de réduire la croissance des cellules qui causent la MP en stimulant une enzyme appelée glucocérébrosidase.
L'étude recueillera des échantillons de liquide céphalo-rachidien, de sang et d'urine avant, pendant et après la prise du médicament sur une période de 6 mois. Dans ces échantillons, les enquêteurs mesureront les niveaux de médicament ambroxol, évalueront si l'enzyme glucocérébrosidase a été stimulée et les niveaux d'autres substances supposées être associées au développement de la MP et confirmeront si le médicament à l'étude a pénétré dans le liquide céphalo-rachidien et le SNC. L'étude administrera des évaluations cliniques et cognitives pour déterminer s'il y a une amélioration des symptômes de la MP du patient. Si l'étude prouve que l'ambroxol pénètre dans le SNC et reproduit nos découvertes actuelles en laboratoire, les enquêteurs passeront à un essai de médicament beaucoup plus vaste pour tester si le médicament à l'étude peut ralentir la progression de la MP.
TYPE D'ÉTUDE
Interventionnel
INSCRIPTION (RÉEL)
23
PHASE
Phase 2
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
Royaume-Uni
London, Royaume-Uni
Leonard Wolfson Experimental Neurology Centre Clinical Research Facility
Thank you Pepsy2020
Translated version:
Status
Completed
THE CONDITIONS
Parkinson's disease
INTERVENTION / TREATMENT
Medication: Ambroxol
DETAILED DESCRIPTION
The AiM-PD study will recruit 20 patients (10 GBA-positive and 10 GBA-negative) diagnosed with Parkinson's disease (PM). Each patient will self-administer the study drug, ambroxol (60 mg per tablet) at 5 intra-dose dose increases over a period of 6 months, as indicated below:
Day 1 to 7: 60 mg three times a day
Day 8-14: 120 mg three times a day
Day 15-21: 180 mg three times a day
Day 22-28: 300 mg three times a day
Day 29-186: 420 mg three times a day
The study drug is authorised in the EU as an over-the-counter drug to treat respiratory diseases by reducing mucus production. Previous studies have shown that ambroxol can enter the brain in models of rodents and non-human primates, and can have an effect on the slowing of PM. The results also indicate that individuals who express the GBA mutation (increased risk of PM) are able to reduce the growth of cells that cause PM by stimulating an enzyme called glucocerebrosidase.
The study will collect samples of cerebrospinal fluid, blood and urine before, during and after taking the drug over a period of 6 months. In these samples, investigators will measure the levels of the drug ambroxol, assess whether the enzyme glucocerebrosidase has been stimulated and the levels of other substances suspected to be associated with the development of PM and confirm whether the study drug has entered the cerebrospinal fluid and CNS. The study will administer clinical and cognitive assessments to determine if there is an improvement in the patient's PM symptoms. If the study proves that ambroxol enters the CNS and reproduces our current laboratory findings, investigators will move to a much larger drug trial to test whether the drug under study can slow the progression of PM.
TYPE OF STUDY
Interventional
REGISTRATION (REAL)
23
Phase
Phase 2
Contacts and locations
This section provides the contact details of those conducting the study and information on where this study is conducted.
Places of study
United Kingdom
London, United Kingdom
Leonard Wolfson Experimental Neurology Centre Clinical Research Facility
there is a trial going on at Kings College Hospital in London I believe.
Hi, do you mean this? Their recent newsletter (June 24) said:
"We are very excited for the launch of the phase III clinical trial ASPro-PD, which will investigate the repurposed cough medication Ambroxol. This study aims to assess the efficacy of ambroxol in slowing down the progression of PD and will be recruiting from a selection of participants with PD that have both the ‘normal’ wildtype GBA1 gene and the mutated GBA1 gene.
Due to delays with reformulating the drug, our previous issue announced that the start date of ASPro-PD would be pushed back. We are thrilled to share that the drug reformulation has been completed. Following this progress with drug development, the ASPro-PD Clinical Trial Unit, with help from the Cure Parkinson’s team and PD Frontline team, have been working hard to get all the necessary arrangements in place ready for recruitment to begin - which we now expect to be in the Autumn.
PD Frontline will be identifying participants that meet preliminary eligibility criteria based on age, disease duration and genetic results. These participants will be referred for a screening visit at a local NHS trial site, where full eligibility will be discussed and any questions about the trial can be answered. PD Frontline will be reaching out to potential participants in the weeks coming up to the start of the trial.
There are 15 potential research centres delivering the ASPro-PD study across the UK, with a target of 330 participants to be recruited over a period of two years.
...
Eligibility
GBA1 carrier / non-carrier
35- 75 y e a r s old
PD diagnosis within the last 7 years
No history of DBS
Further criteria"
Their website is:
Both my husband and I are registered on PD Frontline and we both are taking part on their research programme and have been for the last 3 years.
My husband has PD I don’t but my mother had it. We ve both been genetically tested but are not carriers of the gene.
He wasn’t selected for the trial as he doesn’t carry the gene. He fitted all the criteria except that one. So it seems they are looking for strict criteria before they start the phase 3 trial.
They use high doses of Ambroxol.Tried to start with 75 mgr x1 tabl but it made me ‘“cough “ so I stopped.
I had read that Ambroxol is the best cough medicine for Parkinson's but not available in the US. Our son found a bottle for us in Germany and I've only tried it once. Nothing to report on it, but the Neurologist hadn't heard of it. Yet, I told him that's what I had found as best.
May I suggest the cough medicine Bronchial Wellness. It's all natural and has elderberry and honey in it already. My husband had a "chronic" cough and this cut it. You can get it online or maybe at your health food store. Very good and worth the cost for a bottle.
Ambroxol experience?
Ambroxol 
Has anyone tried earthing or grounding?
