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Abiraterone
Cost questions aside, has anyone noticed a rise in their PSA or increase in side effects when they switched from Zytiga to
Abiraterone
? Thanks so much!
Cost questions aside, has anyone noticed a rise in their PSA or increase in side effects when they switched from Zytiga to
Abiraterone
? Thanks so much!
Vitaminlover
in
Advanced Prostate Cancer
5 years ago
Indomethacin and Abiraterone/Zytiga
Any recent trials / views /experiences for reactivation of
Abiraterone
/Zytiga using Indomethacin ( or similar) please ?
Any recent trials / views /experiences for reactivation of
Abiraterone
/Zytiga using Indomethacin ( or similar) please ?
Miguelnumerouno
in
Advanced Prostate Cancer
5 years ago
TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Outcomes With Abiraterone or Enzalutamide in mCRPC
The authors of this study evaluated outcomes in 168 men with mCRPC prior to treatment with androgen receptor signaling inhibitors (
abiraterone
, enzalutamide).
The authors of this study evaluated outcomes in 168 men with mCRPC prior to treatment with androgen receptor signaling inhibitors (
abiraterone
, enzalutamide).
tango65
in
Advanced Prostate Cancer
5 years ago
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My FIRST Lu-177 infusion !!
I have also been asked to completely discontinue
Abiraterone
and Eligard at least until the Lu-177 treatment is completed. Is this what you guys have also been asked to do ? My treatment is being done in Bombay and everything went very well, better than expected :-) Please do reply.
I have also been asked to completely discontinue
Abiraterone
and Eligard at least until the Lu-177 treatment is completed. Is this what you guys have also been asked to do ? My treatment is being done in Bombay and everything went very well, better than expected :-) Please do reply.
whatsinaname
in
Advanced Prostate Cancer
5 years ago
Re-sensitizing Zytiga and Xtandi
It seems that Niclosamide also has the potential to re-sensitize both enzalutamide (Xtandi) and
abiraterone
acetate (Zytiga). A few find that Zytiga and Xtandi doesn't work for them which is often due to the presence of the splice variant AR-V7.
It seems that Niclosamide also has the potential to re-sensitize both enzalutamide (Xtandi) and
abiraterone
acetate (Zytiga). A few find that Zytiga and Xtandi doesn't work for them which is often due to the presence of the splice variant AR-V7.
Terje
in
Advanced Prostate Cancer
5 years ago
Enzalutamide & Abiraterone ... higher T = more favorable prognosis.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and
Abiraterone
-Treated Castration-Resistant Prostate Cancer.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and
Abiraterone
-Treated Castration-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
AR-V7 and Circulating Tumor Cell DNA Testing - Availability and Use
The detection of AR-V7 in the nucleus is associated with a reduced response to
abiraterone
and enzalutamide and better response to chemotherapy such as docetaxel and cabazitaxel.
The detection of AR-V7 in the nucleus is associated with a reduced response to
abiraterone
and enzalutamide and better response to chemotherapy such as docetaxel and cabazitaxel.
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer
RESULTS We enrolled 118 men with mCRPC who were starting
abiraterone
or enzalutamide treatment.
RESULTS We enrolled 118 men with mCRPC who were starting
abiraterone
or enzalutamide treatment.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Adding Casodex (Bicalutamide) a good idea ?
Would taking it reduce the effectiveness of
Abiraterone
? Any wise thoughts from the experts in this community would be most appreciated. Thanks.
Would taking it reduce the effectiveness of
Abiraterone
? Any wise thoughts from the experts in this community would be most appreciated. Thanks.
hansjd
in
Advanced Prostate Cancer
5 years ago
New to the Group, G9, CHEK2c.1100 inherited, suspected but unproven de novo oligometastatic with inconclusive staging work-up
His conclusion was not sure enough of metastatic disease to advocate for or prescribe
abiraterone
, docetaxel, Radium 223, or other, nor to qualify for oligometastatic de novo clinical trials.
His conclusion was not sure enough of metastatic disease to advocate for or prescribe
abiraterone
, docetaxel, Radium 223, or other, nor to qualify for oligometastatic de novo clinical trials.
Milkweed
in
Advanced Prostate Cancer
5 years ago
Commencement of Zytiga therapy and corresponding rise in cardiovascular events.
Note date of report https://www.onclive.com/conference-coverage/aacr-2019/preexisting-cardiovascular-disease-linked-to-higher-mortality-with-
abiraterone
Note date of report https://www.onclive.com/conference-coverage/aacr-2019/preexisting-cardiovascular-disease-linked-to-higher-mortality-with-
abiraterone
Sxrxrnr1
in
Advanced Prostate Cancer
5 years ago
Current Understanding of Resistance to Abiraterone and Enzalutamide in Advanced PCa
Mentions 14 ongoing clinical trials, including this: "Another approach that we have begun to test here at Johns Hopkins is the use of high-dose testosterone in patients with CRPC that has become resistant to
abiraterone
or enzalutamide (NCT02090114).
Mentions 14 ongoing clinical trials, including this: "Another approach that we have begun to test here at Johns Hopkins is the use of high-dose testosterone in patients with CRPC that has become resistant to
abiraterone
or enzalutamide (NCT02090114).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
Twenty-five patients with metastatic CRPC who had progressed on
abiraterone
/prednisone were included in the study and received PX-866. Unfortunately, the addition of PX-866 to
abiraterone
and prednisone did not result in any antitumor effect.
Twenty-five patients with metastatic CRPC who had progressed on
abiraterone
/prednisone were included in the study and received PX-866. Unfortunately, the addition of PX-866 to
abiraterone
and prednisone did not result in any antitumor effect.
JLS1
in
Advanced Prostate Cancer
5 years ago
Intense ADT before prostatectomy.
Patients were randomly assigned 2:1 to ELAP {enzalutamide and leuprolide with
abiraterone
+ prednisone} or EL {enzalutamide and leuprolide} for 24 weeks followed by RP {radical prostatectomy}."
Patients were randomly assigned 2:1 to ELAP {enzalutamide and leuprolide with
abiraterone
+ prednisone} or EL {enzalutamide and leuprolide} for 24 weeks followed by RP {radical prostatectomy}."
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Abiraterone reduced cost?
I recently found this article and I am intrigued by what the author is saying: https://www.uchicagomedicine.org/forefront/cancer-articles/2017/february/taking-a-high-priced-cancer-drug-with-a-low-fat-meal-can-cut-cost-by-75 Has anyone heard of this or used this method? If he is right then why is it
I recently found this article and I am intrigued by what the author is saying: https://www.uchicagomedicine.org/forefront/cancer-articles/2017/february/taking-a-high-priced-cancer-drug-with-a-low-fat-meal-can-cut-cost-by-75 Has anyone heard of this or used this method? If he is right then why is it
Macscot
in
Advanced Prostate Cancer
5 years ago
Abiraterone + ADT feedback please
To deal with increasing PSA my urologist is recommending
abiraterone
and ADT combination. Has anyone had this combination? Any comments on effectiveness, side effects, effect on quality of life gratefully received.
To deal with increasing PSA my urologist is recommending
abiraterone
and ADT combination. Has anyone had this combination? Any comments on effectiveness, side effects, effect on quality of life gratefully received.
Macscot
in
Advanced Prostate Cancer
5 years ago
Clinical trial / study: BRCA mutations
I have the BRCA2 mutation, and when it became clear nothing was really working for me (lupron, taxotere,
abiraterone
), my MO contacted MSKCC to get me in the study. A PARP inhibitor would have been the next thing on the list, anyway.
I have the BRCA2 mutation, and when it became clear nothing was really working for me (lupron, taxotere,
abiraterone
), my MO contacted MSKCC to get me in the study. A PARP inhibitor would have been the next thing on the list, anyway.
cbgjr
in
Advanced Prostate Cancer
5 years ago
Severe vertigo/dizziness with Abiraterone !!
Now my question : Is this a normal reaction with
Abiraterone
?? If yes, for how many days does this reaction usually last ?? Many thanks guys for any help that you can offer. I am most grateful, as always.
Now my question : Is this a normal reaction with
Abiraterone
?? If yes, for how many days does this reaction usually last ?? Many thanks guys for any help that you can offer. I am most grateful, as always.
whatsinaname
in
Advanced Prostate Cancer
5 years ago
Severe weakness and imbalance
My dad has advanced prostate cancer with current psa of 37 and metastasis to bones .he was diagnosed on May 10th 2018, he didn’t respond well and the treatment changed to Cabazitaxel and
Abiraterone
.... the treatment stopped due to its severe side effects.Its now 3 months that he hasn’t under any treatment
My dad has advanced prostate cancer with current psa of 37 and metastasis to bones .he was diagnosed on May 10th 2018, he didn’t respond well and the treatment changed to Cabazitaxel and
Abiraterone
.... the treatment stopped due to its severe side effects.Its now 3 months that he hasn’t under any treatment
Annie1373
in
Advanced Prostate Cancer
5 years ago
Abiraterone, CYP3A4 and interactions with drugs/ supplements
The opposite effect is caused by CYP3A4 inhibitors, and so in that case the availability of
Abiraterone
is increased. Of course, neither is really desirable.
The opposite effect is caused by CYP3A4 inhibitors, and so in that case the availability of
Abiraterone
is increased. Of course, neither is really desirable.
cbgjr
in
Advanced Prostate Cancer
5 years ago
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