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ASCO GU 2020: Additional Mechanism of Action of PARP Inhibitor Talazoparib Attacks Prostate Cancer Cells, Spares Normal Cells
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (enzalutamide/
abiraterone
acetate).
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (enzalutamide/
abiraterone
acetate).
Balsam01
in
Advanced Prostate Cancer
4 years ago
Fluctuating sugar levels on Zytiga and Prednisone
The doctor referred us to a gastro ent. and stopped the
abiraterone
and prednisone for 2 weeks. Post two weeks the lever enzymes were back in control and the doctor advised us to restart 750 mg of zytiga with 5 mg prednisone.
The doctor referred us to a gastro ent. and stopped the
abiraterone
and prednisone for 2 weeks. Post two weeks the lever enzymes were back in control and the doctor advised us to restart 750 mg of zytiga with 5 mg prednisone.
Life5
in
Advanced Prostate Cancer
5 years ago
Antitumor Activity Seen With Keytruda in mCRPC
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both enzalutamide (Xtandi) and
abiraterone
(Zytiga).
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both enzalutamide (Xtandi) and
abiraterone
(Zytiga).
snoraste
in
Advanced Prostate Cancer
5 years ago
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Criteria for Commencement of Next Line Therapy
Furthermore, it would seem to make more sense to start
abiraterone
therapy, for example, when the PSA is increasing and before it reaches 2 ng/ml. Comments would be appreciated. Cheers, Phil
Furthermore, it would seem to make more sense to start
abiraterone
therapy, for example, when the PSA is increasing and before it reaches 2 ng/ml. Comments would be appreciated. Cheers, Phil
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
Indirect Comparisons of Efficacy Between Combination Approaches in Metastatic Hormone-Sensitive Prostate Cancer
In all, seven trials met eligibility criteria using either docetaxel,
abiraterone
acetate, enzalutamide, or apalutamide in combination with ADT.
In all, seven trials met eligibility criteria using either docetaxel,
abiraterone
acetate, enzalutamide, or apalutamide in combination with ADT.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Any experience with PARP inhibitors (Niraparib)?
He has the following options. 1)
Abiraterone
with denosumab and prednisone 2) Join a clinical trial which combines the above along with immunotheraphy (pembrolizumab).
He has the following options. 1)
Abiraterone
with denosumab and prednisone 2) Join a clinical trial which combines the above along with immunotheraphy (pembrolizumab).
ArabianNights
in
Advanced Prostate Cancer
5 years ago
more possibilities after exhausting SOC?: Enzalutamide-resistant castration-resistant prostate cancer: challenges and solutions
In a cohort of patients previously treated with either enzalutamide or orteronel, a CYP17A inhibitor, 50% showed the evidence of AR amplification and only 13% had a clinically significant response when treated with
abiraterone
.24,25 These observations have been confirmed in a correlative biomarker study
In a cohort of patients previously treated with either enzalutamide or orteronel, a CYP17A inhibitor, 50% showed the evidence of AR amplification and only 13% had a clinically significant response when treated with
abiraterone
.24,25 These observations have been confirmed in a correlative biomarker study
JLS1
in
Advanced Prostate Cancer
5 years ago
Abiraterone Zytiga Copay assistance programs HELP
My husband has been using
abiraterone
successfully for a few months. Having much anxiety as we have to change insurance due to a contract dispute. Right now he is on Zytiga and we are getting the copay assistance through Janssen which makes it almost free.
My husband has been using
abiraterone
successfully for a few months. Having much anxiety as we have to change insurance due to a contract dispute. Right now he is on Zytiga and we are getting the copay assistance through Janssen which makes it almost free.
Grumpyswife
in
Advanced Prostate Cancer
5 years ago
Zytiga (abiraterone acetate)
Does anybody get their Zytiga (
abiraterone
acetate) from India? My Aetna prescription plan was bought out by Wellcare and the co-pay went way up. Been to the Medicare.gov site etc. Out of India it's around $300 a month.
Does anybody get their Zytiga (
abiraterone
acetate) from India? My Aetna prescription plan was bought out by Wellcare and the co-pay went way up. Been to the Medicare.gov site etc. Out of India it's around $300 a month.
lincolnj8
in
Advanced Prostate Cancer
5 years ago
Zytiga vs xtandi
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with
abiraterone
acetate or enzalutamide.
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with
abiraterone
acetate or enzalutamide.
Magnus1964
in
Advanced Prostate Cancer
5 years ago
Impact of Abiraterone Acetate Plus Prednisone or Enzalutamide on Patient-Reported Outcomes in Patients With Metastatic Castration-Resistant
INTERVENTION
Abiraterone
or enzalutamide treatment according to routine practise.
INTERVENTION
Abiraterone
or enzalutamide treatment according to routine practise.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Home in Hawaii.
Found this: https://www.urologytimes.com/aua-annual-meeting/enzalutamide-vs-
abiraterone
-survival-care-costs-compared Mele Kalikimaka Mahalo Randy
Found this: https://www.urologytimes.com/aua-annual-meeting/enzalutamide-vs-
abiraterone
-survival-care-costs-compared Mele Kalikimaka Mahalo Randy
dockam
in
Advanced Prostate Cancer
5 years ago
Zytiga (abiraterone acetate) vs Xtandi (Enzalutamide)
I remember Dr. Myers being cautious regarding Zytiga vs Xtandi. He said that he generally preferred Xtandi because he said in 25 percent of the cases Zytiga could aggravate the cancer. My notes from that visit are " "In 25% of the cases Zytiga makes prostate cancer more aggressive" I have not seen
I remember Dr. Myers being cautious regarding Zytiga vs Xtandi. He said that he generally preferred Xtandi because he said in 25 percent of the cases Zytiga could aggravate the cancer. My notes from that visit are " "In 25% of the cases Zytiga makes prostate cancer more aggressive" I have not seen
cesanon
in
Advanced Prostate Cancer
5 years ago
It is open enrollment time for medicare. Things that seem too good to be true?
I take
Abiraterone
acetate (generic zytiga) and all but 2 plans put me in catastrophic coverage in January. The 2 that didn't purportedly keep me out of the coverage gap all year in 2020 and out of pocket caps in the $2,000 range. If true, that is roughly $8,000 out of pocket saving.
I take
Abiraterone
acetate (generic zytiga) and all but 2 plans put me in catastrophic coverage in January. The 2 that didn't purportedly keep me out of the coverage gap all year in 2020 and out of pocket caps in the $2,000 range. If true, that is roughly $8,000 out of pocket saving.
Philly13
in
Advanced Prostate Cancer
5 years ago
Weakness and fatigue on abiraterone plus Prednisone
My father diagnosed Gleason 4+4= 8 Gleason 3 Mets PCA it's yet castration sensitive...not turned into resistant since 2 years he's been on 12 week palmorelin hormone treatment injection and
abiraterone
1000 mg plus Prednisone 5 mg nowadays he's feeling weak and fatigued and it's kind of fluctuating energy
My father diagnosed Gleason 4+4= 8 Gleason 3 Mets PCA it's yet castration sensitive...not turned into resistant since 2 years he's been on 12 week palmorelin hormone treatment injection and
abiraterone
1000 mg plus Prednisone 5 mg nowadays he's feeling weak and fatigued and it's kind of fluctuating energy
Nirman
in
Advanced Prostate Cancer
5 years ago
Post-race update
10 years older, on Lupron + Xgeva +
Abiraterone
+ others, and not quite 7 months since my last chemo infusion. Not my fastest ever half marathon, but not my slowest either. For those who are newly diagnosed, don't lose hope. There's every chance treatment will work fantastically well!
10 years older, on Lupron + Xgeva +
Abiraterone
+ others, and not quite 7 months since my last chemo infusion. Not my fastest ever half marathon, but not my slowest either. For those who are newly diagnosed, don't lose hope. There's every chance treatment will work fantastically well!
tom67inMA
in
Advanced Prostate Cancer
5 years ago
PSA rising but scans clear
Psa rapidly dropped to 0 .1 and stayed tere for 2 years then began to rise and is now 9.19. 6 months ago my urologist proposed
abiraterone
but as there had been no progression on the scans he decided to wait.
Psa rapidly dropped to 0 .1 and stayed tere for 2 years then began to rise and is now 9.19. 6 months ago my urologist proposed
abiraterone
but as there had been no progression on the scans he decided to wait.
Macscot
in
Advanced Prostate Cancer
5 years ago
Docetaxel Improves Survival in Metastatic Hormone-Naïve Prostate Cancer
At this time, ADT plus enzalutamide represents a new standard of care, but that should also be viewed in context of ADT plus apalutamide, ADT plus
abiraterone
, and ADT plus docetaxel.
At this time, ADT plus enzalutamide represents a new standard of care, but that should also be viewed in context of ADT plus apalutamide, ADT plus
abiraterone
, and ADT plus docetaxel.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Second opinion NYC or Philly
I am being offered a phase 3 double-blind trial,
abiraterone
alone vs
abiraterone
with olaparib, which I will accept if nothing better appears, but I’m not persuaded that this course is the best one, for me, at this time.
I am being offered a phase 3 double-blind trial,
abiraterone
alone vs
abiraterone
with olaparib, which I will accept if nothing better appears, but I’m not persuaded that this course is the best one, for me, at this time.
Johnkelsey
in
Advanced Prostate Cancer
5 years ago
Retreatment With Radium-223 in Patients With Castration-Resistant Prostate Cancer and Bone Metastases
Concomitant cytotoxic agents were not allowed during re-treatment but were allowed at the investigator's discretion during follow-up; other concomitant agents for prostate cancer (including
abiraterone
acetate or enzalutamide) were allowed at investigator's discretion.
Concomitant cytotoxic agents were not allowed during re-treatment but were allowed at the investigator's discretion during follow-up; other concomitant agents for prostate cancer (including
abiraterone
acetate or enzalutamide) were allowed at investigator's discretion.
Balsam01
in
Advanced Prostate Cancer
5 years ago
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