I have generalised morphoea. Have had 8 weeks of methotrexate - 15mg. Have just been to dermatologist who is adding in 500mg of mycophenelate twice a day. Anyone else having both? I'm very tired on the mtx is the mycophenelate going to make it worse? Reading the leaflet it mentions that folic acid reduces effectiveness but Dr didn't tell me to stop taking it? It's to be taken on an empty stomach, how long before or after eating would that be? Any thoughts anyone?