afinator and diarrhea

[HoneyBadgerLady]

I started afinator (10mg) about a week and a half ago after my previous line of treatment stopped working. The intestinal side effects have been awful, especially the severe diarrhea. On the doctor's advice, I'm using imodium but it hasn't helped much. I also take aromasin but the doctor says it's the afinator that's causing the problem. Any suggestions?

[awesome4ever]

Hi HoneyBadgerLady. I started on Afinitor 10mg in March last year and also experienced GI upset, diarrhea and loss of appetite(very strange for me) and persevered for 1 month but loss about 30 pounds. It was not a QOL for me so I stopped and took a month off to allow my body time to heal. After a month I started back at the 5mg dose and had minimal issues for 2 months. I then had my regular scans that showed stable so I agreed to increase my dose up to 7.5mg per day along with Exemestane. I had another series of scans after 3 months and again they were stable. I told my oncologist I was willing to go up to the 10mg dose again but she said that the 7.5mg dose was working so leave things well alone. Now I've been on the regime for 10 months and hope to be able to continue long-term. I did take Imodium 2mg twice a day prophylactically for 2 months but reduced it to once a day...which I probably don't need but I will continue. Hope you find a solution. Take care.

[HoneyBadgerLady in reply to awesome4ever]

Thanks! If my gut doesn't settle down soon, I'll ask about lowering the dose.