Mutations

[Healthplus1]

I am on Orserdu (elacestrant) for a ESR1 mutation and feeling great but my CA27-29 tumor marker numbers continue to rise. Prior to this medication I was on Capecitabine for a PIC3 mutation and prior to that Piqray. Does any one know what meds work to target both mutations simultaneously?

[HelenWi]

Piqray is a targeted therapy and is given for pic3 mutation. I think you can take Orserdu with targeted therapies. Capecitabine is a chemo drug and is typically given by itself.

There is a new drug Trucap that requires you to have one of three mutations, one of which is pic3. Truqap is a targeted therapy. So you might want to ask your oncologist about that.

Best wishes ,

Helen