I have MBC with bone mets in the hips, ribs and spine and started with Arimidex and Zometa in October of 2016. In August of 2017 Ibrance 125 MG was added. About the same time I started the Ibrance my creatinine levels started increasing and I just wondered if this happened to anyone else? My oncologist stated it was the Zometa and took me off it and started me on Xgeva and I will have my 3rd Xgeva shot next week. I was getting the Zometa IV every 4 weeks and now getting the xgeva shot every 4 weeks. Since I've been on the Ibrance I've had severe fatigue and it seems like the aching in my hips, knees and lower back is worse. I have been trying to work full time but I am to the point that I don't think I can keep it up much longer. I've tried to read through the posts and have learned some good information but haven't seen anything about creatinine levels increasing. Thank you and God Bless everyone!