Ideas anyone?

[CichockiS]

Been on xeloda past 4 months was working great but now I can tell it's not working . What's next? Anyone trying immune therapy? Anyone see the article about a new drug that is chemo that actually gets to the bond mets which standard chemo can't do for us

[MaryJ-S]

There isn't immune therapy available except in clinical trials and they are only taking Triple Negative patients. Have you tried radiation for bone mets? Xeloda didn't work for me so I went on Vinolbine for a few years, then Abraxine for a few more years, and then Afinitor with Letrozole (Ibrance wasn't available when I started on Afinitor) which worked for 2 1/2 years.

Now I will be trying Ibrance. I am ER PR positive and HER2 negative. If your cancer is like mine there are lots of treatments available. Hope this helps!

Mary

[CichockiS in reply to MaryJ-S]

You are absolutely correct. No trials for us yet. Hoping for some new ones soon !! I did read an article about Nanoparticles with chemo to get into the bone cancer. Working on mice now.

[Hidden]

Like you my trip on Xeloda came to an end after 11 months - liver met grew again. I have now been put on Vinorelbine which comes as weekly doses or metronomic (Monday Wednesday and Friday doses) 2 weeks on and one off. Our medical scheme doesn't pay for the metronomic one so... I am also ER+ and here in South Africa we are not as exposed to trials as in US. Would like to know more about a new chemo - it sounds interesting. However since we have only recently got Ibrance on the medical scheme formularies I wont hold my breath! So far my scheme doesn't even support it as a "normal" medication - it is on the exclusive list!

Hope you come right with your new regime whatever it turns out to be.

[CichockiS]

Xeloda still working and I feel amazing !! Markers down to 146! My uncle does phone therapy with me and I attribute my thriving to him as well. I live in a new positive being and it has turned my world around !

[Hidden]

So glad your Xeloda is still working. I am now on Navelbine into the 3rd cycle. It is a bit less gentle than the Xeloda but hope it keeps my markers going down - on Xeloda they went all over the place! Just had latest bloods and although the blood counts are good the markers are CEA up to 103 and CA125 down to 68 - both were down after 1 cycle so hope this is not a repeat of the Xeloda story for me.

[PatSailsbery]

After Xeloda I went on Taxol, when that stopped workiing I tried Ibrance / Faslodex (which never worked for me), then was on Doxorubicin (which has a lifetime maximum, which for me was six doses three weeks apart). Currently I am on Eribulin. CA 27.29 is down to 39 and CA15-3 is down to 57. So glad it is working but the neuropathy has gotten substantially worse so I'm sure I'll be switching soon. Next chemo planned will be Gemzitabean (sp?).

I am ER/PR+, HER2-