Am I the only one who reacts so dramatically to antihistamines CREAM ?

[Pippins2]

Hi I posted some time ago how I used antihistamine cream and my legs went into overdrive but thought, although I doubted it ,that it could be coincidence. Well today I had to use it again as an itchy rash was getting worse and I used the cream last around 6 o'clock.

My RLS has been going nuts since 7.30,no let up and very severe in my arms too.This is very usual for me these days, it I do get symptoms they are mild and soon walked off so I am now 99% sure this is due to the antihistamine

It is Boots own brand and the active ingredient is Mepyramine Maleate.

Strangely I can take non sedating Antihistamines orally without any problems.

Has anyone else reacted to antihistamine in cream form? I find it a bit odd .It's 4 in the morning and my RLS is on par with my bad old days of augmentation ,I can't even sit for 20 seconds- all from a cream ?

Thanks Pipps

So after searching it see.s that mepyramine is a 1st generation antihistamine Does anyone know of an antihistamine CREAM that contains a 2nd generation antihistamine?

[Jelbea]

Hi Pippins2 - For many years I have had bad itching of my skin. It can be extreme and believe it or not is caused by ordinary water. When it is bad I cannot shower or bathe but have to use wipes to cleanse skin. I have tried different anti-itch creams but the best for me is Lanacane. You can get this on Amazon or in a pharmacy. The mepyramine you mention seems to be a sedating antihistamine and even used in the cream it can make you drowsy. I looked this up on the internet.

I hope you get relief very soon. Itching can be very upsetting when it goes on and on and affects sleep, etc.

Good Wishes

[Sinor]

I react to certain antihistamines too. Phenergan tablets give me the worst restless legs. I've recently discovered the are dopamine antagonists.

[SueJohnson in reply to Sinor]

If you need an antihistamine, the following are safe for RLS: OTC Claritin (loratadine, Clarityn), zyrtec (Cetirizine ), or allegra (Fexofenadine, Telfast ).

[Sinor in reply to SueJohnson]

Thanks. It seems the sleepy ones are the issue.

[SueJohnson]

Zyrtec (cetirizine) cream

[Embroiderer]

In any case it’s not advisable for anyone to use antihistamines as a topical cream as you could develop an allergy to all forms of antihistamine via any route.

[Typicallygaslit]

Yep, there are tons of histamine receptors in the feet. I have had horrible reactions from all sorts of creams that all have had antihistaminic properties, even herbal ones with nettles and burdock. Rose scented body lotion has been ok, I also use rose fragrance otherwise.