gut microbiota and dopamine

[Bernaldi]

A growing body of evidence showed that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson’s disease (PD). Microbiota-targeted interventions could play a protective role in PD by regulating the gut microbiota-gut-brain axis. Sodium butyrate (NaB) could improve gut microbiota dysbiosis in PD and other neuropsychiatric disorders. However, the potential mechanism associated with the complex interaction between NaB and gut microbiota-gut-brain communication in PD needs further investigation.

From: ncbi.nlm.nih.gov/pmc/articl...

So -- if butyrate, which when taken "correctly" can affect Parkinson's, that shows that gut microbiota affect dopamine in some way. Which indicates that RLS may be caused by a problem in the gut microbiota. My own opinion is that the across-the-board ingestion of antibiotics is the cause of so many of these "diseases" that are increasing rapidly. If you kill off your gut bacteria instead of the longer path of balancing it, the consequences occur. I am choosing to first, not ingest things that my gut can't handle, and second, everything in my power to heal the gut's microbiota. For me, the thing I'm doing now is taking a supplement called Tributyrin-X, which you can look up if you want. My doctor just told me about another, that has studies showing that it has a beneficial effect on Parkinson's. Because it changes the environment for the needed bacteria, allowing them to reach the levels needed for health.

[Joolsg]

Very helpful. The gut, is known as the second brain and has as many neurons as the the brain.

[Bernaldi in reply to Joolsg]

We need to, as a group, start looking in places other than "what drug can I take." I understand the desperation that comes from night after night after night of this horrid condition, but also -- we just HAVE to start looking elsewhere.

[SurvivorD in reply to Bernaldi]

Thank you very interesting. I have been taking Probiotic 299. I have taken your advice and read up about the one you taking. You seem quite clued up and well read and therefore would like your opinion on whether it is safe to take if I have genetic heart disease??

[Bernaldi in reply to SurvivorD]

I'm not a doctor and have no qualifications to advise you on what to do or not do if you have heart disease. I'm a retired engineer and often see a "big picture" in situations where others are only looking at the details.

There is a Facebook group for the company that makes this supp; the company is called HealthyGut. They have coaches on the FB group who would be more qualified to answer that question.

[SurvivorD in reply to Bernaldi]

I am totally with you on the aspect of the "big picture". Will go onto their site. Thanks 👍

[Joolsg in reply to Bernaldi]

I've been aware of this for decades. I have taken Symprove pro biotic for years and take Pre biotics regularly. There's a great book by Giulia Enders, called 'GUT'.

[restlessstoz in reply to Joolsg]

Yes Jools, this book is brilliant and very readable. I read it years ago and it was one of my first forays into gut health and the microbiome. We have a long way to go before understanding even a fraction of how our gut helps our overall health. For those who aren't such avid readers, there are some UTube videos to watch by her as well.

I agree Bernaldi that we definitely do need to look at 'the big picture' but also to realise that for us in the RL'SYNDROME' world, there are probably going to be as many different things that trigger RLS, and as there are many different things that will be cures- or at least thing that will/do help sufferers. This makes it particularly hard to set up studies etc as they will only be targeting one or two of the many dozens of possible areas involved. At least if we all join the support groups then we fund at least some research.

[Bernaldi]

I've also been told that the vagus nerve has a lot to do with leaky gut, but I haven't yet looked into that. Vagus nerve stuff is just starting to get attention.

[restlessstoz in reply to Bernaldi]

I agree Bernaldi that we definitely do need to look at 'the big picture' but also to realise that for us in the RL'SYNDROME' world, there are probably going to be as many different things that cause/trigger RLS, and as there are many different things that will be cures- or at least thing that will/do help sufferers. This makes it particularly hard to set up studies etc as they will only be targeting one or two of the many dozens of possible areas involved. At least if we all join the support groups then we fund at least some research.

[Joolsg in reply to Bernaldi]

healthunlocked.com/rlsuk/po...

I follow RLS research, and posted about vagus nerve 9 months ago. You may find the article interesting.

[Zenawarrior73]

this is super interesting … thank you for sharing recently my stomach has been so off after having antibiotics for a horsefly bite that went infected and my RLS got quickly worse. I take a probiotic daily but noticed in my pharmacy the other day rather than the standard one with the strain of lactophillus you can buy different ones for different things ie for travel abroad or after antibiotics etc so I might try a combination. I’ve heard sauerkraut bought in the jars is really good for increasing gut microbiome. Dr Tim Spector has a few books out on this subject which are really good.

[CsiguZ]

I made a lot of research on the connection of the microbiome and RLS, you can check my previous posts, comments. There are some research made by dr. Leonard B. Weinstock on the overgrowth of the gut bacteria in the small intestine (SIBO) and RLS. I strongly belive in a lot of case our microbiome is causing RLS, but unfortunately it’s hard to fix our gut.

[Jumpey]

I agree.Thanks for posting.

[DicCarlson]

Tributyrin-X is just one supplement, and looks excellent - but there are many offering Tributyrin which is a short-chain saturated fat found principally in butter. The Tributyrin website has great information on this. If you have RLS and any gut symptoms including loose stools, constipation, heartburn, GERD, bloating, etc., it is worth a try. You could also add Triphala (an herbal supplement) and the probiotic LP299v (linked to iron absorption) and perhaps Atrantil.

healthygut.com/product/trib...

[Bernaldi in reply to DicCarlson]

I hadn't thought of triphala, which has been used for thousands of years. Before they had abx though. Since I have some I may add that in for a while and see if it makes a discernible difference. However, I don't have obvious gut problems. That doesn't mean they aren't there though.

[nocturne in reply to DicCarlson]

I've been taking triphala for about a year. It helps with constipation, but does nothing for my RLS.

[Bernaldi]

Thanks. Constipation is not one of my problems. I think triphala is an intestinal normalizer.

[nocturne in reply to Bernaldi]

Lol, lucky for you! : )