Bupenorphine (Morphine Sulphate)

[VENEER]

Hi Sue, I have now taken 1.25 ml of Buprenorpine (Morphine Sulphate)and my symptoms are still persistent?????I can take another 1.25ml later tonight but can only use 2.5ml per day thereafter. Veneer

[Joolsg]

Morphine Sulphate is oral, liquid morphine. Completely different to Buprenorphine.The RLS UK and Mayo Clinic guidelines set out the average doses of drugs for refractory RLS.

Morphine is 15-45mg daily so if you are taking 2.5ml a day, it is far below the starting and average dose.

Buprenorphine is taken as a pill or patch and average dose for RLS is around 1.5 -2mg a day.

[Joolsg in reply to Joolsg]

Also, are you still on 300mg pregabalin? There is a risk of respiratory depression when you take pregabalin AND opioids, usually if there's a history of respiratory issues. Buprenorphine has the lowest risk of respiratory depression and if it helps your severe RLS, you could then slowly reduce the pregabalin.

[SueJohnson]

I agree with Joolsg.

[Jumpey]

I take 12.5mls of oramorph. Your dose is too low. Increase it gradually until you find the amount that helps.

[Munroist]

Please make sure you know which medication you actually have before changing the dosage