Like so many of us, I am ALSO weaning off of pramipexole. I have been taking a "low" 0.375 or 1.5 of the 0.25 mg tablet (with 600 mg Gabapentin) at 1030 pm (prior to a 12 am bedtime) for the dreaded RLS onset at 130-2 am, which would then last for 1 to 3 hours. It was working but I was feeling the potential of augmentation so started reducing pram by 1/4 tablet per week. I am down to 1/2 tablet (while still taking 600 mg gab) and have been there for about a month trying occasionally 1/4 tablet w moderate success - success being no 130 am RLS onsets).
I have not tried marijuana or opioids (and don't plan to...)
BUT NOW....my CBD supplier (Luvive) has developed a new CBD Sleep. I am using it (1 mL at bedtime) and it seems, seems to lessen onsets. I am ready to go all the way to achieve complete elimination of the pramipexole (I have never used opioids for RLS). Then I hope to start reducing Gab, as well, while continuing Luvive
I recommend trying Luvive Sleep. If you do, ask for Samer and tell him Dwain referred you. Luvive is based out of Scottsdale AZ. I have been buying from them for two years and they seem to be honest w high quality, organic CBDs (gummies, tinctures, creams, and sleep). Link: luvivecbd.com/
Sidebar: I also have RLS "onsets" when sitting (driving or riding) in the car, especially after about 4 pm. r. Recently, I realized that it seemed I was sitting on nerves : ) that were triggering RLS. I JUST bought a gel pad ( a good one for $35) and have used it three days as we are on the road and NO RLS!!!!! I pray, pray, pray that He showed me this potential solution.
Everyday I awake w no RLS, I thank God in Jesus name for a restFULL night.
We are allllll so very different. Our trials and tribulations seem to be so unique. I liken it to what doctors call IBS for those of us w digestive issues that my doc/your doc do not understand. They seem to think if they label it (RLS or I S) that it will just go away ...yeah, right!!