Suddenly I started getting RLS, even on low dose Methadone. I am thinking it is the Azelastine as it is an antihistamine, but I cannot find any literature on it.
The only other thing that changed was a slight reduction in Lithium. I don't have any discontinuation symptoms, so I don't think it is that, but it could be a factor.
The antihistamine in Azelastine is NOT a sedating one, so shouldn't cause any problem with RLS.
However if you can't identify any other trigger I guess it must be that.
You'll have to try stopping using it fior a while.
Yes. I hate to do it. I have two choices, stop the lithium taper or stop the Azelistine. I don't know which is worse. Thinking more clearly but having trouble breathing or breathe easier and not be able to function as well. Ugh!
I see your difficulty.
How serious is your nasal problem, could you use a non-histamine spray?
I would say that sedating antihisatmines can quite quickly make RLS worse, possibly the same day. In which case you might not have to stop it for long.
I think it's the lithium withdrawal. I took a regular dose and it was fine when I took a nap!
I’ve been using Azelastine for almost 5 years and it doesn’t cause any problems for me.
Thank you!
RLS and antidepressants 
RLS 
RLS and Osteoarthritis 
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Rls
