Methadone and edema

[Jrskyhook32]

I’ve been on methadone 5mg once a day for a month. I noticed yesterday that I had edema in my left ankle. I had to go to the ER After taking all kinds of tests no causes that they could tell they told me to keep my leg up. But as soon as I do the RLS kicks in. Does anyone know if methadone causes edema?

[Pippins2]

Hi i have no experience myself but a friend of mine had the same reaction .She had to stop the Methadone due to edema , told it was a rare reaction .I would see your GP asap to discuss this x

[Jrskyhook32 in reply to Pippins2]

Thank you. I’m going to see him on Monday

[Cats2]

This is interesting. I never really paid attention to my ankles until I added gabapentin to my methadone dose for RLS. Then I developed some ankle swelling. I looked it up and gabapentin can cause it (rarely though, I think). I never thought about it being possibly due to the 10mg methadone. I guess I'll do a little research on that possibility. It goes away if I am really active during the day (up and down steps, walking a lot, etc).

[Leelee49]

I’ve got it in both feet at the moment, I don’t use methadone though, I take pregabalin (lyrica) and I’m sure it’s that what’s causing it.

[TheDoDahMan]

I've been on 10 mg methadone per day since November, 2018. No edema. The methadone prescription has given me my life back. Blessed be Dr B!