Has anyone tried clemastine fumarate ( an anti-histamine)? I know most anti histamines make RLS much worse but I cannot find out whether this particular one is a baddie.
It’s not mentioned in my book on RLS so wonder if anyone has any personal experience of it.
It’s shown promising results in a recent MS trial so I’d like to give it a try but not if it makes my RLS worse.
I can see if i can find out for you. Only know one person who might know.
Apparently it is a sedating antihistamine so not good for RLS. 
Where is this information from, Jools? I like to know where we are reading from. 
I do not suggest this med with RLS, and/or combining it with other sedation meds. This med is multi purpose also used for PTSD, and other anxiety problems, also bipolar.
Hi nightdancer,
The report is in my bi monthly MS magazine “New Pathways” and is a summary of the phase II clinical trial results published in The Lancet ( UK medical journal). It’s available over the counter so it would be a cheap way to improve MS but not at the expense of worsening my RLS.
I actually use Zyrtec in my rotation of nightly helps. even though it is a non drowsy formula it puts me to sleep with no RL. I can’t use it more than 2 days in a row though. It stops making me drowsy after that. I have to wait 4 days before using again to get the same effect.
Which Anti-depressant tablets do not make RLS worse?
Anti-seizure medication
RLS website - list of safe anti depressants 
Anxiety and RLS 
Anti depressants
