I have been on Mirapex/Pramipexole for decades. I have reduced my dosage to .5mg for a couple of years and have been able to ignore the temporary (two or three days) augmentations that arise and then subside. Lately, I have been experiencing a really rough augmentation that has lasted for a couple of weeks. It is starting earlier (6 or 7). I usually take the Mirapex with dinner at 6:30, the Mirapex finally kicks in around 9:30pm but RLS will rise it's ugly head in the morning again, Usually it it has only occurred on one side of my body's arm and/or leg per day and by using a hand held massager, I have been able to calm it. Now it is affecting all limbs. I feel like a spastic. Massage isn't working. I cannot stand clothing touching my skin.
So when desperate, I google RLS and see if anyone has come up with a magical solution yet. This time, I ran into an article on Seratame which I include because some of it seems to make sense. I have ordered a bottle and will let you know in a couple of months if it helps.
Your link is an advert from Californian supplement manufacturer Pure Biogenics promoting their magnesium, probiotic and vitamin supplement 'Seratame'.
While they report some good points about inflammation in their marketing, in my view they are overly dismissive of iron supplementation: while iron didn't work for me, it reportedly helps the majority.
Magnesium supplementation works well for some (including me) but not at all for others (including my brother).
BookmanJoe reported trying Seratame some 3 years ago and that after a couple of months it seemed to work, but never referred to it again and stopped posting. Whether he continued to take it, and whether his RLS symptoms stopped...
I don't know whether this supplement is, at US$40-50 a month, a cost effective way for US forum members to try magnesium glycinate and a lactobacillus probiotic etc? It seems expensive, but perhaps that's what these things cost in the US... And if it works, the price may be incidental...
Pure Biogenics to date only supply Seratame in the US, so UK and international members can't order it. As we've so many US members on this forum, I'm a bit surprised that we haven't heard more about this - but it will certainly be interesting for members to learn how you get on with it!
Low levels of iron can be the result of the inflammation therefore supplementing it without reducing the inflammation is probably why it doesn't help many people.
Seratame was recommended by rlsrebel who used to have a website where she discussed things that helped RLS.( I haven't been able to find it lately.) It contains ingredients that can help but they can all be bought separately and more cheaply. It may help a little but since you are augmenting it is unlikely it will help much.
As you're augmenting, not much will help the severe RLS until you're off Pramipexole completely. I tried EVERYTHING during my time augmenting on Ropinirole. Revitive leg machine, Restiffic foot compresses, compression stockings, magnesium sprays and tablets, mucuna pruriens, deep tissue massage guns. Apple cider vinegar, pickle juice, celery juice .Etc. If it was mentioned as a possible help on this forum, I tried it.
The only thing that helped a little was cannabis. It gave me 30 mins sleep after 4 to 5 day's of no sleep.
I wasted a lot of money.
As this product is mainly magnesium and probiotics, it may be better and cheaper to buy separately.
Wishing you strength to get through the last stage of withdrawal.
No I didn't. It was on my list to try if Buprenorphine didn't work. Luckily Buprenorphine has been fantastic for me. If my doctors ever stop prescribing it, I will apply for LDN. It's only available from private clinics here in the UK and we have to pay for the prescription, around £30 a month.I was in touch with FlowerGirl back in 2018 when she used LDN in microdoses to reduce Oxycontin and pregabalin. She then increased to 4.5mg and it completely resolved her severe RLS.
So it definitely works very well for many.
How are you getting on? Are you managing to sleep?
Yes, Im better, of course not cured. Cutting out sugar has helped me. I also have to take care what I eat. Im luckier than many people as the tiny dose of mirapexin usually works. I also take tramal from time to time and Kratom. I'm not sure about the situation of LDN in Greece. I have a great new GP so I will talk to him about it. I'll let you know how I get on. However as what I'm doing seems to be working reasonably well I may wait a bit. Glad to hear that you are doing so well
The RLS reasoning and footnotes are spot-on - focusing on the inflammation is important. I would agree that IF it works - switch to individual supplements. I use Jarrow Ideal Bowel Support (with LP299V), and I take Curcumin (with a new "enhanced" formula called Meriva). Also Magnesium called Magtein (Magnesium L-Threonate, often called "brain magnesium").
I haven't tried Seratme but have looked at the site. I agree with them that RLS is primarily a matter of inflammation. Their supplement is not a magic bullet and just helps te recover from the damage that the inflammation has done, and you'll need to follow the dietary advice to eliminate the causes of the inflammation for success.
I've eliminated my RLS by avoiding inflammatory foods and supplementing vitamins and minerals individualy rather than with a proprietary blend like Seratme.
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