I didn't develop rls until after taking zoloft for my anxiety and depression. Hit me like a ton of bricks! I switched over to lexapro but I swear it's gotten worse. I wake up between 430 and 5 EVERY morning with tenseness in my arms and legs. I'm going through alot right now...anxiety and depression, premenopause, nerves compression in my legs...im a mess...now this rls. Dr prescribed mirapex but im scared to death to take it...ive read the side effects and that is SCARY! !! I don't know what to do! One dr thinks it's my anxiety waking me up....I hate meds..I have a med phobia. I feel like with all I'm dealing with im gonna lose my mind!!