Reanalysis of the PACE trial: A large-scale... - Ramsays Disease

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Reanalysis of the PACE trial

Theresa60 profile image
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A large-scale, government-funded trial, known as PACE, claimed psychotherapy and exercise helped the estimated 250,000 sufferers of the devastating illness, M.E. (myalgic encephalomyelitis).

“We found that the groups receiving CBT or GET did not significantly outperform the control group…” Carolyne Wilshire.

Manifesting as unrelenting fatigue and profound pain, the condition, also known as chronic fatigue syndrome, has no known cure and is made worse by exertion.

Sufferers are often confined to their beds, unable to walk, and need help even to shower – an action that could then lay them low for hours, days, weeks or longer.

When the results of the five-year PACE trial were published in 2011, researchers claimed that graded exercise therapy (GET) and cognitive behaviour therapy (CBT) were “moderately effective” forms of treatment.

The trial concluded that both treatments led to recovery in over a fifth of patients.

Parliament has previously heard claims that the data was deliberately flawed to “remove people from long-term benefits and reduce the welfare bill”.

After a long legal battle, unpublished data from the trial was released and has now been independently reanalysed. The paper, published in the journal BMC Psychology, has found that the benefits reported for psychotherapy and exercise therapy are modest and not statistically reliable.

bmcpsychology.biomedcentral...

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Theresa60 profile image
Theresa60
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Effort profile image
Effort

Blog looking at where trial flaws show up.

mecfsresearchreview.me/2018...

Ian123 profile image
Ian123

The research is not reliable and the biopsychosocial hypothesis is unevidenced so how did it become the dominant illness model in NHS treatment regimes

nhs.uk/conditions/chronic-f...

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